Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice

Posted by klaurent Columbia

Kavli Affiliate: Stavros Lomvardas | Authors: Elizaveta Bashkirova, Nell Klimpert, Kevin Monahan, Christine Campbell, Jason Osinski, Longzhi Tan, Ira Schieren, Ariel Pourmorady, Rebecca Stecky, Gilad Barnea, Xiaoliang Sunney Xie, Ishmail Abdus-Saboor, Benjamin Shykind, Bianca Jones Marlin, Richard Gronostajski, Alexander Fleischmann and Stavros Lomvardas | Summary: Olfactory receptor (OR) choice represents an example of genetically hardwired […]


Continue.. Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice

Myomatrix arrays for high-definition muscle recording

Posted by klaurent Columbia, UCSD / Salk

Kavli Affiliate: Eiman Azim, Rui Costa | Authors: Bryce Chung, Muneeb Zia, Kyle A. Thomas, Jonathan A. Michaels, Amanda Jacob, Andrea Pack, Matthew J. Williams, Kailash Nagapudi, Lay Heng Teng, Eduardo Arrambide, Logan Ouellette, Nicole Oey, Rhuna Gibbs, Philip Anschutz, Jiaao Lu, Yu Wu, Mehrdad Kashefi, Tomomichi Oya, Rhonda Kersten, Alice C Mosberger, Sean O`Connell, […]


Continue.. Myomatrix arrays for high-definition muscle recording

A modular circuit architecture coordinates the diversification of courtship strategies in Drosophila

Posted by klaurent Rockefeller

Kavli Affiliate: Vanessa Ruta | Authors: Rory T Coleman, Ianessa Morantte, Gabriel T Koreman, Megan L Cheng, Yun Ding and Vanessa Ruta | Summary: Identifying a mate is a central imperative for males of most species but poses the challenge of distinguishing a suitable partner from an array of potential male competitors or females of […]


Continue.. A modular circuit architecture coordinates the diversification of courtship strategies in Drosophila

Motivation upregulates the adaptive response in sensorimotor learning

Posted by klaurent Hopkins

Kavli Affiliate: Vikram Chib | Authors: Salma Khatib, Vikram S. Chib and Firas Mawase | Summary: Motivational state plays a critical role in our ability to learn new motor skills; however, the mechanisms by which motivation influences motor learning are poorly understood. Using a motor learning paradigm in which motivation was varied in a trial-by-trial […]


Continue.. Motivation upregulates the adaptive response in sensorimotor learning

Engineered Immunogens to Elicit Antibodies Against Conserved Coronavirus Epitopes

Posted by klaurent UCSF

Kavli Affiliate: Robert J Edwards | Authors: Brenda Kapingidza, Daniel J Marston, Caitlin Harris, Daniel Wrapp, Kaitlyn Winters, Dieter Mielke, Lu Xiaozhi, Qi Yin, Andrew Foulger, Rob Parks, Maggie Barr, Amanda Newman, Alexandra Schaefer, Amanda Eaton, Justine Mae Flores, Austin Hamer, Nicholas J Cantazaro, Jr., Michael L Mallory, Melissa D Mattocks, Christopher Berverly, Brianna Rhodes, […]


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Ventromedial Prefrontal Cortex and Basolateral Amygdala Projections to Ventromedial Striatum Encode Active Avoidance Behavior

Posted by klaurent UCSF

Kavli Affiliate: Lisa Gunaydin | Authors: Teagan E Bullock and Lisa A. Gunaydin | Summary: Active avoidance is a fundamental defensive behavior, defined as performing a voluntary action to escape a noxious stimulus. Active avoidance serves as an adaptive response to threat, ensuring safety. In individuals with anxiety disorders and post-traumatic stress disorder, avoidance behavior […]


Continue.. Ventromedial Prefrontal Cortex and Basolateral Amygdala Projections to Ventromedial Striatum Encode Active Avoidance Behavior

maskNMF: A denoise-sparsen-detect approach for extracting neural signals from dense imaging data

Posted by klaurent Columbia

Kavli Affiliate: Liam Paninski, Darcy Peterka | Authors: Amol Pasarkar, Ian Kinsella, Pengcheng Zhou, Melissa Wu, Daisong Pan, Jiang Lan Fan, Zhen Wang, Lamiae Abdeladim, Darcy S. Peterka, Hillel Adesnik, Na Ji and Liam Paninski | Summary: A number of calcium imaging methods have been developed to monitor the activity of large populations of neurons. […]


Continue.. maskNMF: A denoise-sparsen-detect approach for extracting neural signals from dense imaging data

Machine assisted annotation in neuroanatomy

Posted by klaurent UCSD / Salk

Kavli Affiliate: David Kleinfeld | Authors: Kui Qian, David Kleinfeld, Beth Friedman and Yoav Freund | Summary: One routine and necessary, yet time-consuming task in neuroanatomy is the annotation of labeled cells relative to the background. Currently, staining and imaging techniques enable the marking of specific cell groups with fluorescent dyes. Modern high throughput scanning […]


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Single-cell analysis of prenatal and postnatal human cortical development

Posted by klaurent UCSF

Kavli Affiliate: Arnold R. Kriegstein | Authors: Dmitry Velmeshev, Yonatan Perez, Zihan Yan, Jonathan E Valencia, David R Castaneda-Castellanos, Li Wang, Lucas Schirmer, Simone Mayer, Brittney Wick, Shaohui Wang, Tomasz J. Nowakowski, Mercedes Paredes, Eric J. J. Huang and Arnold Kriegstein | Summary: We analyze more than 700,000 single-nucleus RNA-seq profiles from 106 donors during […]


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Lysosomal TMEM106B interacts with galactosylceramidase to regulate myelin lipid metabolism

Posted by klaurent Yale

Kavli Affiliate: Stephen Strittmatter | Authors: Hideyuki Takahashi, Azucena Perez-Canamas, Hongping Ye, Xianlin Han and Stephen M. Strittmatter | Summary: TMEM106B is an endolysosomal transmembrane protein not only associated with multiple neurological disorders including frontotemporal dementia, Alzheimer’s disease, and hypomyelinating leukodystrophy but also potentially involved in COVID-19. Additionally, recent studies have identified amyloid fibrils of […]


Continue.. Lysosomal TMEM106B interacts with galactosylceramidase to regulate myelin lipid metabolism