Gapped-kmer sequence modeling robustly identifies regulatory vocabularies and distal enhancers conserved between evolutionarily distant mammals

Posted by klaurent Hopkins

Kavli Affiliate: Michael Beer | Authors: Jin Woo Oh and Michael A Beer | Summary: Gene regulatory elements drive many complex biological phenomena such as fetal development, and their mutations are linked to a multitude of common human diseases. The phenotypic impacts of regulatory variants are often tested using their conserved orthologous counterparts in model […]


Continue.. Gapped-kmer sequence modeling robustly identifies regulatory vocabularies and distal enhancers conserved between evolutionarily distant mammals

Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model

Posted by klaurent Yale

Kavli Affiliate: Michael J Higley | Authors: Samantha Bottom-Tanzer, Sofia Corella, Jochen Meyer, Mary Sommer, Luis Bolanos, Timothy Murphy, Sadi Quinones, Shane Heiney, Matthew Shtrahman, Michael Whalen, Rachel Oren, Michael J Higley, Jessica A Cardin, Farzad Noubary, Moritz Armbruster and Chris Dulla | Summary: Traumatic brain injury (TBI) is the leading cause of death in […]


Continue.. Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model

Phospholipid transport to the bacterial outer membrane through an envelope-spanning bridge

Posted by dbos UCSD / Salk

Kavli Affiliate: Robert E. Clark | Authors: Georgia Isom, Benjamin F Cooper, Robert Clark, Anju Kudhail, Damian Charles Ekiert, Gira Bhabha and Syma Khalid | Summary: The outer membrane of Gram-negative bacteria provides a formidable barrier, essential for both pathogenesis and antimicrobial resistance. Biogenesis of the outer membrane requires the transport of phospholipids across the […]


Continue.. Phospholipid transport to the bacterial outer membrane through an envelope-spanning bridge

Structure-Function Coupling in Highly Sampled Individual Brains

Posted by klaurent UCSD / Salk

Kavli Affiliate: Deanna J. Greene | Authors: Aishwarya Rajesh, Nicole A. Seider, Dillan J. Newbold, Babatunde Adeyemo, Scott Marek, Deanna J. Greene, Abraham Z Snyder, Joshua S. Shimony, Timothy O Laumann, Nico U.F. Dosenbach and Evan M. Gordon | Summary: Structural connections (SC) between distant regions of the brain support synchronized function known as functional […]


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Mice require proprioception to establish long-term visuospatial memory

Posted by klaurent Columbia

Kavli Affiliate: Michael Goldberg | Authors: Michael E. Goldberg, Olivia Rutler, Randy M. Bruno, Jung Man Park, Serena Persaud, Stylianos Kosmidis and Nina Hirano | Summary: Because the retina moves constantly, the retinotopic representation of the visual world is spatially inaccurate and the brain must transform this spatially inaccurate retinal signal to a spatially accurate […]


Continue.. Mice require proprioception to establish long-term visuospatial memory

Synaptic Basis of Behavioral Timescale Plasticity

Posted by klaurent Columbia

Kavli Affiliate: Franck Polleux, Attila Losonczy | Authors: Kevin C Gonzalez, Adrian Negrean, Zhenrui Liao, Franck Polleux and Attila Losonczy | Summary: Learning and memory are fundamental to adaptive behavior and cognition. Various forms of synaptic plasticity have been proposed as cellular substrates for the emergence of feature selectivity in neurons underlying episodic memory. However, […]


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Whole-cortex in situ sequencing reveals peripheral input-dependent cell type-defined area identity

Posted by dbos Hopkins

Kavli Affiliate: Patrick Kanold | Authors: Xiaoyin Chen, Stephan Fischer, Mara CP Rue, Aixin Zhang, Didhiti Mukherjee, Patrick O Kanold, Jesse Gillis and Anthony Zador | Summary: The cortex is composed of neuronal types with diverse gene expression that are organized into specialized cortical areas. These areas, each with characteristic cytoarchitecture (Brodmann 1909; Vogt and […]


Continue.. Whole-cortex in situ sequencing reveals peripheral input-dependent cell type-defined area identity

Retrosplenial inputs drive diverse visual representations in the medial entorhinal cortex

Posted by dbos Yale

Kavli Affiliate: Michael J Higley | Authors: Olivier Dubanet and Michael J. Higley | Summary: The ability of rodents to use visual cues for successful navigation and goal-directed behavior has been long appreciated, although the neural mechanisms supporting sensory representations in navigational circuits are largely unknown. Navigation is fundamentally dependent on the hippocampus and closely […]


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Fe-TAMLs as a new class of small molecule peroxidase probes for correlated light and electron microscopy

Posted by klaurent UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Stephen R Adams, Mason R Mackey, Ranjan Ramachandra, Thomas J Deerinck, Guillaume A Castillon, Sebastien Phan, Junru Hu, Daniela Boassa, John T Ngo and Mark H Ellisman | Summary: We introduce Fe-TAML, a small molecule-based peroxidase as a versatile new member of the correlated fluorescence and electron microscopy toolkit. […]


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Decoding transcriptomic signatures of Cysteine String Protein alpha-mediated synapse maintenance

Posted by dbos Yale

Kavli Affiliate: Sreeganga Chandra | Authors: Na Wang, Biqing Zhu, Mary Alice Allnutt, Rosalie M Grijalva, Hongyu Zhao and Sreeganga S Chandra | Summary: Synapse maintenance is essential for generating functional circuitry and decrement in this process is a hallmark of neurodegenerative disease. While we are beginning to understand the basis of synapse formation, much […]


Continue.. Decoding transcriptomic signatures of Cysteine String Protein alpha-mediated synapse maintenance