Simultaneous, cortex-wide and cellular-resolution neuronal population dynamics reveal an unbounded scaling of dimensionality with neuron number

Posted by dbos Rockefeller

Kavli Affiliate: Alipasha Vaziri | Authors: Jason Manley, Jefferey Demas, Hyewon Kim, Francisca Martinez Traub and Alipasha Vaziri | Summary: The brain’s remarkable properties arise from collective activity of millions of neurons. Widespread application of dimensionality reduction to multi-neuron recordings implies that neural dynamics can be approximated by low-dimensional “latent” signals reflecting neural computations. However, […]


Continue.. Simultaneous, cortex-wide and cellular-resolution neuronal population dynamics reveal an unbounded scaling of dimensionality with neuron number

Value construction through sequential sampling explains serial dependencies in decision making

Posted by dbos Columbia

Kavli Affiliate: Daphna Shohamy and Michael Shadlen | Authors: Ariel Zylberberg, Akram Bakkour, Daphna Shohamy and Michael N Shadlen | Summary: Many decisions are expressed as a preference for one item over another. When these items are familiar, it is often assumed that the decision maker assigns a value to each of the items and […]


Continue.. Value construction through sequential sampling explains serial dependencies in decision making

Long-Term Potentiation Produces a Sustained Expansion of Synaptic Information Storage Capacity in Adult Rat Hippocampus

Posted by dbos UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: Dana E Cobb-Lewis, Anne George, Shannon Hu, Katherine Packard, Mingyuan Song, Oliver Nguyen-Lopez, Emily Ikematsu Tesone, Jhanay Rowden, Julie Wang and Maya Opendak | Summary: Long-term potentiation (LTP) has become a standard model for investigating synaptic mechanisms of learning and memory. Increasingly, it is of interest to understand how […]


Continue.. Long-Term Potentiation Produces a Sustained Expansion of Synaptic Information Storage Capacity in Adult Rat Hippocampus

The lateral habenula integrates age and experience to promote social transitions in developing rats

Posted by dbos Hopkins

Kavli Affiliate: Maya Opendak | Authors: Dana E Cobb-Lewis, Anne George, Shannon Hu, Katherine Packard, Mingyuan Song, Oliver Nguyen-Lopez, Emily Ikematsu Tesone, Jhanay Rowden, Julie Wang and Maya Opendak | Summary: Social behavior deficits are an early-emerging marker of psychopathology and are linked with early caregiving quality. However, the infant neural substrates linking early care […]


Continue.. The lateral habenula integrates age and experience to promote social transitions in developing rats

Glioma-Induced Alterations in Excitatory Neurons are Reversed by mTOR Inhibition

Posted by dbos Columbia, UCSD / Salk

Kavli Affiliate: Elizabeth Hillman, Mark Ellisman and Darcy Peterka | Authors: Alexander R. Goldberg, Athanassios Dovas, Daniela Torres, Sohani Das Sharma, Angeliki Mela, Edward M. Merricks, Markel Olabarria, Leila Abrishami Shokoohm, Hanzhi T. Zhao, Corina Kotidis, Peter Calvaresi, Ashwin Viswanathan, Matei A. Banu, Aida Razavilar, Tejaswi D. Sudhakar, Ankita Saxena, Cole Chokran, Nelson Humala, Aayushi […]


Continue.. Glioma-Induced Alterations in Excitatory Neurons are Reversed by mTOR Inhibition

RAPSYN-Mediated Neddylation of BCR-ABL Alternatively Determines the Fate of Philadelphia Chromosome-positive Leukemia

Posted by klaurent Rockefeller

Kavli Affiliate: Li Zhao | Authors: mengya Zhao, Beiying Dai, Xiaodong Li, Yixin Zhang, Chun Qiao, Yaru Qin, Zhao Li, Qingmei Li, Shuzhen Wang, Yong Yang and Yijun Chen | Summary: Philadelphia chromosome-positive (Ph+) leukemia is a fatal hematological malignancy. Although standard treatments with tyrosine kinase inhibitors (TKI) have achieved remarkable success in prolonging patient […]


Continue.. RAPSYN-Mediated Neddylation of BCR-ABL Alternatively Determines the Fate of Philadelphia Chromosome-positive Leukemia

Simultaneous multi-transient linear-combination modeling of MRS data improves uncertainty estimation

Posted by dbos Hopkins

Kavli Affiliate: Jeremias Sulam | Authors: Helge J Zollner, Christopher B. Davies-Jenkins, Dunja B. Simicic, Assaf Tal, Jeremias Sulam and Georg Oeltzschner | Summary: TPurpose The interest in applying and modeling dynamic MRS has recently grown. 2D modeling yields advantages for the precision of metabolite estimation in interrelated MRS data. However, it is unknown whether […]


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Recurrent connections enable point attractor dynamics and dimensionality reduction in a connectome-constrained model of the insect learning center

Posted by dbos Hopkins

Kavli Affiliate: Grace Hwang and Kechen Zhang | Authors: Justin Joyce, Raphael Norman-Tenazas, Patricia Rivlin, Grace M. Hwang, Isaac Western, Kechen Zhang, William Gray-Roncal and Brian Robinson | Summary: The learning center in the insect, the mushroom body (MB) with its predominant population of Kenyon Cells (KCs), is a widely studied model system to investigate […]


Continue.. Recurrent connections enable point attractor dynamics and dimensionality reduction in a connectome-constrained model of the insect learning center

EEG responses to rapidly unfolding stochastic sounds reflect precision tracking

Posted by dbos Hopkins

Kavli Affiliate: Mounya Elhilali | Authors: Sijia Zhao, Benjamin Skerritt-Davis, Mounya Elhilali, Frederic Dick and Maria Chait | Summary: The brain is increasingly viewed as a statistical learning machine, where our sensations and decisions arise from the intricate interplay between bottom-up sensory signals and constantly changing expectations regarding the surrounding world. Which statistics does the […]


Continue.. EEG responses to rapidly unfolding stochastic sounds reflect precision tracking

Aberrant Connectivity Across the Lifespan in a Mouse Model of Alzheimer’s disease and Rescue by mGlur5 Modulator Treatment

Posted by dbos Yale

Kavli Affiliate: Stephen Strittmatter | Authors: Francesca Mandino, Xilin Shen, Gabriel Desrosiers-Gregoire, David O’Connor, Bandhan Mukherjee, Ashley Owens, An Qu, John Onofrey, Xenophon Papademetris, Mallar Chakravarty, Stephen M. Strittmatter and Evelyn MR Lake | Summary: Amyloid accumulation in Alzheimer’s disease (AD) is associated with synaptic damage and altered connectivity in brain networks. While measures of […]


Continue.. Aberrant Connectivity Across the Lifespan in a Mouse Model of Alzheimer’s disease and Rescue by mGlur5 Modulator Treatment