Kavli Affiliate: Daniel Kronauer | Authors: Taylor Hart, Lindsey E. Lopes, Dominic D. Frank and Daniel J.C. Kronauer | Summary: While the neural basis of age-related decline has been extensively studied (1–3), less is known about changes in neural function during the pre-senescent stages of adulthood. Adult neural plasticity is likely a key factor in […]
Kavli Affiliate: David Linden | Authors: Jessie Benedict, Robert H. Cudmore, David J. Linden, Diarra Oden and Aleah Spruell | Summary: Mammalian parenting is an unusually demanding commitment. How did evolution co-opt the reward system to ensure parental care? Previous work has implicated the lateral habenula (LHb), an epithalamic nucleus, as a potential intersection of […]
Kavli Affiliate: Robert Edwards | Authors: Qianyi E Zhang, Jared Lindenberger, Ruth Parsons, Bhishem Thakur, Rob Parks, Chan Soo Park, Xiao Huang, Salam Sammour, Katarzyna Janowska, Taylor N Spence, Robert J. Edwards, Mitchell Martin, Wilton B Williams, Sophie Gobeil, David C Montefiori, Bette Korber, Kevin O’Neil Saunders, Barton F Haynes, Barton F. Haynes, Rory Henderson […]
Kavli Affiliate: Franck Polleux | Authors: Yusuke Hirabayashi, Tommy L Lewis, Jr., Yudan Du, Daniel M Virga, Aubrianna Decker, Giovanna Coceano, Jonatan Alvelid, Maela Paul, Stevie Hamilton, Parker Kneis, Yasufumi Takahashi, Jellert Gaublomme, Ilaria Testa and Franck Polleux | Summary: In neurons of the mammalian central nervous system (CNS), axonal mitochondria are thought to be […]
Kavli Affiliate: Attila Losonczy | Authors: Zhenrui Liao, Kevin Christian Gonzalez, Deborah Li, Catalina Yang, Donald Holder, Natalie McClain, Guofeng Zhang, Stephen Evans, Maria Chavarha, Jane Yi, Christopher Makinson, Michael Lin, Attila Losonczy and Adrian Negrean | Summary: Fast electrical signaling in dendrites is central to neural computations that support adaptive behaviors. Conventional techniques lack […]
Kavli Affiliate: Daniel Kronauer | Authors: Kip D Lacy, Taylor Hart and Daniel J.C. Kronauer | Summary: According to Mendel’s second law, chromosomes segregate randomly in meiosis. Non-random segregation is primarily known for cases of selfish meiotic drive in females, in which particular alleles bias their own transmission into the oocyte1,2. Here, we report a […]
Kavli Affiliate: Anatol Kreitzer | Authors: Robyn St. Laurent, Kelly M Kusche, Anatol C Kreitzer and Robert C Malenka | Summary: Background The avoidance of aversive stimuli due to negative reinforcement learning is critical for survival in real-world environments, which demand dynamic responding to both positive and negative stimuli that often conflict with each other. […]
Kavli Affiliate: Loren Frank | Authors: Anna K Gillespie, Daniela A Astudillo Maya, Eric L. Denovellis, Sachi Desse and Loren M Frank | Summary: Hippocampal replay – the time-compressed, sequential reactivation of ensembles of neurons related to past experience – is a key neural mechanism of memory consolidation. Replay typically coincides with a characteristic pattern […]
Kavli Affiliate: Jeremy Willsey | Authors: Belinda Wang, Rasika Vartak, Yefim Zaltsman, Zun Zar Chi Naing, Kelsey M Hennick, Benjamin J Polacco, Ali Bashir, Manon Eckhardt, Mehdi Bouhaddou, Jiewei Xu, Nawei Sun, Micaela Lasser, Yuan Zhou, Keelan Z Guiley, Una Chan, Julia A Kaye, Prachi Khare, Sam Drake, Vanessa Drury, David F Burke, Silvano Gonzalez, […]
Kavli Affiliate: Yifan Cheng | Authors: He Chen, Yifan Cheng, Jianqiang Dong, Jie Mao, Xin Wang, Yuan Gao, Yuchao Li, Chengzhi Wang and Qiong Wu | Summary: Predicting the properties of proteins is an important procedure in protein engineering. It determines the subspace of mutations for protein modifications, which is critical to the success of […]