Functional architecture of intracellular oscillations in hippocampal dendrites

Posted by klaurent Columbia

Kavli Affiliate: Attila Losonczy | Authors: Zhenrui Liao, Kevin Christian Gonzalez, Deborah Li, Catalina Yang, Donald Holder, Natalie McClain, Guofeng Zhang, Stephen Evans, Maria Chavarha, Jane Yi, Christopher Makinson, Michael Lin, Attila Losonczy and Adrian Negrean | Summary: Fast electrical signaling in dendrites is central to neural computations that support adaptive behaviors. Conventional techniques lack […]


Continue.. Functional architecture of intracellular oscillations in hippocampal dendrites

Unselfish meiotic drive maintains heterozygosity in a parthenogenetic ant

Posted by klaurent Rockefeller

Kavli Affiliate: Daniel Kronauer | Authors: Kip D Lacy, Taylor Hart and Daniel J.C. Kronauer | Summary: According to Mendel’s second law, chromosomes segregate randomly in meiosis. Non-random segregation is primarily known for cases of selfish meiotic drive in females, in which particular alleles bias their own transmission into the oocyte1,2. Here, we report a […]


Continue.. Unselfish meiotic drive maintains heterozygosity in a parthenogenetic ant

Intercalated amygdala dysfunction drives extinction deficits in the Sapap3 mouse model of obsessive-compulsive disorder

Posted by klaurent UCSF

Kavli Affiliate: Anatol Kreitzer | Authors: Robyn St. Laurent, Kelly M Kusche, Anatol C Kreitzer and Robert C Malenka | Summary: Background The avoidance of aversive stimuli due to negative reinforcement learning is critical for survival in real-world environments, which demand dynamic responding to both positive and negative stimuli that often conflict with each other. […]


Continue.. Intercalated amygdala dysfunction drives extinction deficits in the Sapap3 mouse model of obsessive-compulsive disorder

Neurofeedback training can modulate task-relevant memory replay in rats

Posted by klaurent UCSF

Kavli Affiliate: Loren Frank | Authors: Anna K Gillespie, Daniela A Astudillo Maya, Eric L. Denovellis, Sachi Desse and Loren M Frank | Summary: Hippocampal replay – the time-compressed, sequential reactivation of ensembles of neurons related to past experience – is a key neural mechanism of memory consolidation. Replay typically coincides with a characteristic pattern […]


Continue.. Neurofeedback training can modulate task-relevant memory replay in rats

A foundational atlas of autism protein interactions reveals molecular convergence

Posted by dbos UCSF

Kavli Affiliate: Jeremy Willsey | Authors: Belinda Wang, Rasika Vartak, Yefim Zaltsman, Zun Zar Chi Naing, Kelsey M Hennick, Benjamin J Polacco, Ali Bashir, Manon Eckhardt, Mehdi Bouhaddou, Jiewei Xu, Nawei Sun, Micaela Lasser, Yuan Zhou, Keelan Z Guiley, Una Chan, Julia A Kaye, Prachi Khare, Sam Drake, Vanessa Drury, David F Burke, Silvano Gonzalez, […]


Continue.. A foundational atlas of autism protein interactions reveals molecular convergence

Protein property prediction based on local environment by 3D equivariant convolutional neural networks

Posted by dbos UCSF

Kavli Affiliate: Yifan Cheng | Authors: He Chen, Yifan Cheng, Jianqiang Dong, Jie Mao, Xin Wang, Yuan Gao, Yuchao Li, Chengzhi Wang and Qiong Wu | Summary: Predicting the properties of proteins is an important procedure in protein engineering. It determines the subspace of mutations for protein modifications, which is critical to the success of […]


Continue.. Protein property prediction based on local environment by 3D equivariant convolutional neural networks

Distinct patterns of genetic variation at low-recombining genomic regions represent haplotype structure

Posted by klaurent Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: Jun Ishigohoka, Karen Bascón-Cardozo, Andrea Bours, Janina Fuß, Arang Rhie, Jacquelyn Mountcastle, Bettina Haase, William Chow, Joanna Collins, Kerstin Howe, Marcela Uliano-Silva, Olivier Fedrigo, Erich D. Jarvis, Javier Pérez-Tris, Juan Carlos Illera and Miriam Liedvogel | Summary: Genetic variation of the entire genome represents population structure, yet individual loci […]


Continue.. Distinct patterns of genetic variation at low-recombining genomic regions represent haplotype structure

Predictive Sequence Learning in the Hippocampal Formation

Posted by dbos UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: Yusi Chen, Huanqiu Zhang, Mia Cameron and Terrence J Sejnowski | Summary: The hippocampus receives sequences of sensory inputs from the cortex during exploration and encodes the sequences with millisecond precision. We developed a predictive autoencoder model of the hippocampus including the trisynaptic and monosynaptic circuits from the entorhinal […]


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Substrate stiffness modulates the emergence and magnitude of senescence phenotypes

Posted by dbos Hopkins

Kavli Affiliate: Denis Wirtz | Authors: Bartholomew Starich, Fan Yang, Derin Tanrioven, Heng-Chung Kung, Joanne Baek, Praful R. Nair, Pratik Kamat, Nico Macaluso, Joon Eoh, Kyu Sang Han, Luo Gu, Sean Sun, Pei-Hsun Wu, Denis Wirtz and Jude M. Phillip | Summary: Cellular senescence is a major driver of aging and disease. Here we show […]


Continue.. Substrate stiffness modulates the emergence and magnitude of senescence phenotypes

Brain-state mediated modulation of inter-laminar dependencies in visual cortex

Posted by klaurent Yale

Kavli Affiliate: Anirvan Nandy | Authors: Anirban Das, Alec G. Sheffield, Anirvan S. Nandy and Monika P. Jadi | Summary: Adaptive information processing, comprised of local computations and their efficient routing, is crucial for flexible brain function. Spatial attention is a quintessential example of this adaptive process. It is critical for recognizing and interacting with […]


Continue.. Brain-state mediated modulation of inter-laminar dependencies in visual cortex