Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation

Posted by dbos Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Anthony Dial Ramnauth, Madhavi Tippani, Heena R. Divecha, Alexis R. Papariello, Ryan A Miller, Erik D Nelson, Elizabeth A. Pattie, Joel E. Kleinman, Kristen R. Maynard, Leonardo Collado-Torres, Thomas M. Hyde, Keri Martinowich, Stephanie C Hicks and Stephanie Cerceo Page | Summary: The dentate gyrus of the hippocampus is […]


Continue.. Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation

Modulation of aggression by social novelty recognition memory in the hippocampal CA2 region

Posted by dbos Columbia

Kavli Affiliate: Steven Siegelbaum | Authors: Andres Villegas and Steven A Siegelbaum | Summary: The dorsal CA2 subregion (dCA2) of the hippocampus exerts a critical role in social novelty recognition (SNR) memory and in the promotion of social aggression. Whether the social aggression and SNR memory functions of dCA2 are related or represent independent processes […]


Continue.. Modulation of aggression by social novelty recognition memory in the hippocampal CA2 region

Two routes to value-based decisions in Parkinsons disease: differentiating incremental reinforcement learning from episodic memory

Posted by dbos Columbia

Kavli Affiliate: Daphna Shohamy | Authors: Peter Jendrichovsky, Hey-Kyoung Lee and Patrick O Kanold | Summary: Patients with Parkinsons disease are impaired at incremental reward-based learning. It is typically assumed that this impairment reflects a loss of striatal dopamine. However, many open questions remain about the nature of reward-based learning deficits in Parkinsons. Recent studies […]


Continue.. Two routes to value-based decisions in Parkinsons disease: differentiating incremental reinforcement learning from episodic memory

Dark exposure reduces high-frequency hearing loss in C57BL/6J mice

Posted by dbos Hopkins

Kavli Affiliate: Hey-Kyoung Lee and Patrick Kanold | Authors: Peter Jendrichovsky, Hey-Kyoung Lee and Patrick O Kanold | Summary: Plastic changes in the brain are primarily limited to early postnatal periods. Recovery of adult brain plasticity is critical for the effective development of therapies. A brief (1-2 week) duration of visual deprivation (dark exposure, DE) […]


Continue.. Dark exposure reduces high-frequency hearing loss in C57BL/6J mice

A 2D Gabor-wavelet baseline model out-performs a 3D surface model in scene-responsive cortex

Posted by dbos UCSD / Salk

Kavli Affiliate: John Serences | Authors: Anna Shafer-Skelton, Timothy F Brady and John T Serences | Summary: Understanding 3D representations of spatial information, particularly in naturalistic scenes, remains a significant challenge in vision science. This is largely because of conceptual difficulties in disentangling higher-level 3D information from co-occurring features and cues (e.g., the 3D shape […]


Continue.. A 2D Gabor-wavelet baseline model out-performs a 3D surface model in scene-responsive cortex

Coordination and persistence of aggressive visual communication in Siamese fighting fish

Posted by dbos Columbia

Kavli Affiliate: Liam Paninski | Authors: Claire P. Everett, Amy L. Norovich, Jessica E. Burke, Matthew R Whiteway, Pei-Yin Shih, Yuyang Zhu, Liam Paninski and Andres Bendesky | Summary: Animals coordinate their behavior with each other during both cooperative and agonistic social interactions. Such coordination often adopts the form of “turn taking”, in which the […]


Continue.. Coordination and persistence of aggressive visual communication in Siamese fighting fish

Distinct anatomical and functional corticospinal inputs innervate different spinal neuron types

Posted by dbos Columbia

Kavli Affiliate: Liam Paninski | Authors: Samaher Fageiry, Claire L Warriner, Jackson Loper, Liam Paninski, Thomas Reardon, Thomas M. Jessell, Rui M. Costa and Andrew Miri | Summary: The corticospinal tract exerts its influence on movement through spinal neurons, which can be divided into types that exhibit distinct functions. However, it remains unknown whether these […]


Continue.. Distinct anatomical and functional corticospinal inputs innervate different spinal neuron types

The breath shape controls intonation of mouse vocalizations

Posted by dbos UCSF

Kavli Affiliate: Kevin Yackle | Authors: Alastair MacDonald and Kevin Yacklei | Summary: Intonation in speech is the control of vocal pitch to layer expressive meaning to communication, like increasing pitch to indicate a question. Also, stereotyped patterns of pitch are used to create distinct “words”, like the ten sounds in the murine lexicon. A […]


Continue.. The breath shape controls intonation of mouse vocalizations

Disorganized Inhibitory Dynamics and Functional Connectivity in Hippocampal area CA1 of 22q11.2 Deletion Mutant Mice

Posted by dbos Columbia

Kavli Affiliate: Attila Losonczy | Authors: Stephanie A Herrlinger, Bovey Rao, Margaret E Conde Paredes, Anna L Tuttman, Haroon Arain, Erdem Varol, Joseph A Gogos and Attila Losonczy | Summary: Individuals with the 22q11.2 deletion syndrome, one of the strongest genetic risk factors for schizophrenia, demonstrate cognitive impairments such as episodic memory dysfunction. Place cell […]


Continue.. Disorganized Inhibitory Dynamics and Functional Connectivity in Hippocampal area CA1 of 22q11.2 Deletion Mutant Mice

Bidirectional Regulation of Motor Circuits Using Magnetogenetic Gene Therapy

Posted by klaurent Rockefeller

Kavli Affiliate: Jeffrey M. Friedman | Authors: Santiago R Unda, Roberta Marongiu, Lisa E Pomeranz, Jonathan P Dyke, Edward K Fung, Logan Grosenick, Rick Zirkel, Aldana M Antoniazzi, Sofya Norman, Conor M Liston, Chris B Schaffer, Nozomi Nishimura, Sarah A Stanley, Jeffrey M Friedman and Michael G Kaplitt | Summary: Regulating the activity of discrete […]


Continue.. Bidirectional Regulation of Motor Circuits Using Magnetogenetic Gene Therapy