Altered development and network connectivity in a human neuronal model of 15q11.2 deletion-related neurodevelopmental disorders

Posted by dbos Hopkins

Kavli Affiliate: Dwight Bergles | Authors: Christa Whelan Habela, Shiyu Liu, Arens Taga, Raha Dastgheyb, Norman Haughey, Dwight E Bergles, Hongjun Song, Guo-Li Ming and Nicholas J. Maragakis | Summary: The chromosome 15q11.2 locus is deleted in 1.5% of patients with genetic epilepsy and confers a risk for intellectual disability and schizophrenia. Individuals with this […]


Continue.. Altered development and network connectivity in a human neuronal model of 15q11.2 deletion-related neurodevelopmental disorders

Accept-reject decision-making revealed via a quantitative and ethological study of C. elegans foraging

Posted by dbos UCSD / Salk

Kavli Affiliate: Sreekanth Chalasani | Authors: Jessica A Haley, Tianyi Chen, Mikio Aoi and Sreekanth H Chalasani | Summary: Decision-making is a ubiquitous component of animal behavior that is often studied in the context of foraging. Foragers make a series of decisions while locating food (food search), choosing between food types (diet or patch choice), […]


Continue.. Accept-reject decision-making revealed via a quantitative and ethological study of C. elegans foraging

Lateral prefrontal cortex controls interplay between working memory and actions

Posted by dbos UCSD / Salk

Kavli Affiliate: Anastasia Kiyonaga | Authors: Anastasia Kiyonaga, Jacob Miller and Mark D’Esposito | Summary: Humans must often keep multiple task goals in mind, at different levels of priority and immediacy, while also interacting with the environment. We might need to remember information for an upcoming task while engaged in more immediate actions. Consequently, actively […]


Continue.. Lateral prefrontal cortex controls interplay between working memory and actions

Machine-learning convergent melanocytic morphology despite noisy archival slides

Posted by dbos UCSF

Kavli Affiliate: Michael Keiser | Authors: Mikio Tada, Garrett Gaskins, Sina Ghandian, Nicholas Mew, Michael J. Keiser and Elizabeth S. Keiser | Summary: Melanocytic atypia, ranging from benign to malignant, often leads to diagnostic discordance, complicating its prediction by machine learning models. To overcome this, we paired H&E-stained histology images with contiguous or serial sections […]


Continue.. Machine-learning convergent melanocytic morphology despite noisy archival slides

3’UTR-directed, kinase proximal mRNA decay inhibits C/EBPβ phosphorylation/activation to suppress senescence in tumor cells

Posted by dbos Columbia

Kavli Affiliate: Aniruddha Das | Authors: Jacqueline Salotti, Nida Asif, Srikanta Basu, Aniruddha Das, Mei Yang, Baktiar Karim, Karen Saylor, Nancy Martin, David A Scheiblin, Sweta Misra, Brian Luke, Thorkell Andresson, Stephen Lockett, Lino Tessarollo and Peter F Johnson | Summary: C/EBPβ is a potent regulator of oncogene-induced senescence (OIS) and the SASP. C/EBPβ is […]


Continue.. 3’UTR-directed, kinase proximal mRNA decay inhibits C/EBPβ phosphorylation/activation to suppress senescence in tumor cells

Manipulating attentional priority creates a trade-off between memory and sensory representations in human visual cortex

Posted by dbos UCSD / Salk

Kavli Affiliate: John Serences | Authors: Rosanne L Rademaker and John Serences | Summary: People often remember visual information over brief delays while actively engaging with ongoing inputs from the surrounding visual environment. Depending on the situation, one might prioritize mnemonic contents (i.e., remembering details of a past event), or preferentially attend sensory inputs (i.e., […]


Continue.. Manipulating attentional priority creates a trade-off between memory and sensory representations in human visual cortex

Heterogeneous responses to embryonic critical period perturbations among different components of the Drosophila larval locomotor circuit

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Niklas Krick, Jacob Davies, Bramwell Coulson, Daniel Sobrido-Camean, Michael Miller, Matthew C.W. Oswald, Aref Arzan Zarin, Richard Baines and Matthias Landgraf | Summary: As developing neural circuits become functional, they undergo a phase of heightened plasticity in response to intrinsic and/or extrinsic stimuli. These developmental windows are termed critical […]


Continue.. Heterogeneous responses to embryonic critical period perturbations among different components of the Drosophila larval locomotor circuit

Exploiting correlations across trials and behavioral sessions to improve neural decoding

Posted by dbos Columbia

Kavli Affiliate: Liam Paninski | Authors: Yizi Zhang, Hanrui Lyu, Cole Hurwitz, Shuqi Wang, Charles Lincoln Findling, Felix Hubert, Alexandre Pouget, International Brain Laboratory, Erdem Varol and Liam Paninski | Summary: Traditional neural decoders model the relationship between neural activity and behavior within individual trials of a single experimental session, neglecting correlations across trials and […]


Continue.. Exploiting correlations across trials and behavioral sessions to improve neural decoding

Mitochondrial Hyperactivity and Reactive Oxygen Species Drive Innate Immunity to the Yellow Fever Virus-17D Live-Attenuated Vaccine

Posted by dbos Rockefeller

Kavli Affiliate: Charles M. Rice | Authors: Samantha G Muccilli, Bejamin Schwarz, Forrest Jessop, Jeffrey G. Shannon, Eric Bohrnsen, Byron Shue, Seon-Hui Hong, Thomas Hsu, Alison W. Ashbrook, Joseph W. Guarnieri, Justin Lack, Douglas C. Wallace, Catharine M. Bosio, Margaret R. MacDonald, Charles M Rice, Jonathan W Yewdell and Sonja M. Best | Summary: The […]


Continue.. Mitochondrial Hyperactivity and Reactive Oxygen Species Drive Innate Immunity to the Yellow Fever Virus-17D Live-Attenuated Vaccine

Learning-related oscillatory dynamics in the human cortico-basal ganglia network during motor sequence initiation in Parkinson’s Disease

Posted by dbos UCSF

Kavli Affiliate: Reza Abbasi Asl and Philip Starr | Authors: Kara N Presbrey, Thomas A Wozny, Kenneth H Louie, Simon Little, Philip A Starr, Reza Abbasi-Asl and Doris D Wang | Summary: Learning fine motor sequences is crucial to quality of life and can be altered in Parkinson’s Disease (PD). It may be partially driven […]


Continue.. Learning-related oscillatory dynamics in the human cortico-basal ganglia network during motor sequence initiation in Parkinson’s Disease