Neuroscience – Page 25 – Kavli Institute Pre-Print Publications

Mapping Somatosensory Afferent Circuitry to Bone Identifies Neurotrophic Signals Required for Fracture Healing

Posted by dbos June 7, 2024June 17, 2024Rockefeller

Kavli Affiliate: Li Zhao; | Authors: Mingxin Xu, Neelima Thottappillil, Masnsen Cherief, Zhao Li, Manyu Zhu, Xin Xing, Mario Gomez-Salazar, Juliet Mukiri Mwirigi, Ishwarya Sankaranarayanan, Diana Tavares-Ferreira, Chi Zhang, Xue-Wei Wang, Mary Archer, Yun Guan, Robert J. Tower, Patrick Cahan, Theodore J. Price, Thomas L. Clemens and Aaron W. James | Summary: The profound pain […]

Continue..

Role of microglia in stress-induced alcohol intake in female and male mice

Posted by dbos June 6, 2024June 17, 2024Yale

Kavli Affiliate: Marina Picciotto; | Authors: Alexa Soares, Vernon Garcia-Rivas, Caroline Fai, Merrilee Thomas, Xiaoying Zheng, Marina Picciotto and Yann Mineur | Summary: Rates of alcohol use disorder (AUD) have escalated in recent years, with a particular increase among women. Women are more susceptible to stress-induced alcohol drinking, and preclinical data suggest that stress can […]

Continue..

Scalable electron tomography for connectomics

Posted by dbos June 6, 2024June 17, 2024UCSD / Salk

Kavli Affiliate: Mark Ellisman; | Authors: Aaron T Kuan, Sebastien Phan, Keun-Young Kim, Mason Mackey, Minsu Kim, Steven T Peltier, Mark Ellisman and Wei-Chung Allen Lee | Summary: We demonstrate limited-tilt, serial section electron tomography (ET), which can non-destructively map brain circuits over large 3D volumes and reveal high-resolution, supramolecular details within subvolumes of interest. […]

Continue..

Probabilistic graph-based model uncovers previously unseen druggable vulnerabilities in major solid cancers

Posted by dbos June 6, 2024June 17, 2024Rockefeller

Kavli Affiliate: Franck Polleux; | Authors: Koki Nakamura, Saeko Aoyama-Ishiwatari, Takahiro Nagao, Mohammadreza Paaran, Christopher J. Obara, Yui Sakurai-Saito, Jake Johnston, Yudan Du, Shogo Suga, Masafumi Tsuboi, Makoto Nakakido, Kouhei Tsumoto, Yusuke Kishi, Yukiko Gotoh, Chulhwan Kwak, Hyun-Woo Rhee, Jeong Kon Seo, Hidetaka Kosako, Clint Potter, Bridget Carragher, Jennifer Lippincott-Schwartz, Franck Polleux and Yusuke Hirabayashi […]

Continue..

PDZD8-FKBP8 tethering complex at ER-mitochondria contact sites regulates mitochondrial complexity

Posted by dbos June 3, 2024June 17, 2024Columbia

Continue..

Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites

Posted by dbos May 31, 2024June 17, 2024Rockefeller, Yale

Kavli Affiliate: Timothy A. Ryan and Pietro De Camilli; | Authors: Lorena Benedetti, Ruolin Fan, Aubrey V. Weigel, Andrew S. Moore, Patrick R. Houlihan, Mark Kittisopikul, Grace Park, Alyson Petruncio, Philip M. Hubbard, Song Pang, C. Shan Xu, Harald F. Hess, Stephan Saalfeld, Vidhya Rangaraju, David E. Clapham, Pietro De Camilli, Timothy A. Ryan and […]

Continue..

Behavioral impairments are linked to neuroinflammation in mice with Cerebral Cavernous Malformation disease

Posted by dbos May 30, 2024June 17, 2024UCSD / Salk

Kavli Affiliate: Stephan Anagnostaras; | Authors: Joseph Offenberger, Bianca Chen, Leigh-Ana Rossitto, Irisa Jin, Liam Conaboy, Helios Gallego-Gutierrez, Bliss Nelsen, Eduardo Frias-Anaya, David J. Gonzalez, Stephan Anagnostaras and Miguel Alejandro Lopez-Ramirez | Summary: Background Cerebral Cavernous Malformations (CCMs) are neurovascular abnormalities in the central nervous system (CNS) caused by loss of function mutations in KRIT1 […]

Continue..

Temporal-Coherence Induces Binding in Responses to Sound Sequences in Ferret Auditory Cortex

Posted by dbos May 29, 2024June 17, 2024Hopkins

Kavli Affiliate: Mounya Elhilali/p> | Authors: Kai Lu, Kelsey Dutta, Ali Mohammed, Mounya Elhilali and Shihab Shamma | Summary: Binding the attributes of a sensory source is necessary to perceive it as a unified entity, one that can be attended to and extracted from its surrounding scene. In auditory perception, this is the essence of […]

Continue..

Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility

Posted by dbos May 29, 2024June 17, 2024UCSF

Kavli Affiliate: Jeremy Willsey/p> | Authors: Kate E McCluskey, Katherine M Stovell, Karen Law, Elina Kostyanovskaya, James Schmidt, Cameron RT Exner, Jeanselle Dea, Elise Brimble, Matthew W State, A Jeremy Willsey and Helen Rankin Willsey | Summary: The comorbidity of autism spectrum disorders and severe gastrointestinal symptoms is well-established, yet the molecular underpinnings remain unknown. […]

Continue..

Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids

Posted by dbos May 19, 2024May 28, 2024Yale

Kavli Affiliate: Flora Vaccarino | Authors: Soraya Scuderi, Tae-Yun Kang, Alexandre Jourdon, Liang Yang, Feinan Wu, Alex Nelson, George M. Anderson, Jessica Mariani, VIVEKANANDA SARANGI, Alexej Abyzov, Andre Levchenko and Flora M. Vaccarino | Summary: The repertory of neurons generated by progenitor cells depends on their location along antero-posterior and dorso-ventral axes of the neural […]

Continue..