Comparing Automated Subcortical Volume Estimation Methods; Amygdala Volumes Estimated by FSL and FreeSurfer Have Poor Consistency

Posted by dbos Hopkins

Kavli Affiliate: Martin Lindquist | Authors: Patrick Sadil and Martin A Lindquist | Summary: Subcortical volumes are a promising source of biomarkers and features in biosignatures, and automated methods facilitate extracting them in large, phenotypically rich datasets. However, while extensive research has verified that the automated methods produce volumes that are similar to those generated […]


Continue.. Comparing Automated Subcortical Volume Estimation Methods; Amygdala Volumes Estimated by FSL and FreeSurfer Have Poor Consistency

Human-specific paralogs of SRGAP2 induce neotenic features of microglia structural and functional maturation

Posted by dbos Columbia

Kavli Affiliate: Franck Polleux | Authors: Carlos Diaz-Salazar, Marine A KRZISCH, Juyoun Yoo, Patricia Nano, Aparna Bhaduri, Rudolph Jaenisch and Franck Polleux | Summary: Microglia play key roles in shaping synaptic connectivity during neural circuits development. Whether microglia display human-specific features of structural and functional maturation is currently unknown. We show that the ancestral gene […]


Continue.. Human-specific paralogs of SRGAP2 induce neotenic features of microglia structural and functional maturation

Neuropathologically-directed profiling of PRNP somatic and germline variants in sporadic human prion disease

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Gannon A. McDonough, Yuchen Cheng, Katherine Morillo, Ryan N. Doan, Connor J. Kenny, Aaron Foutz, Chae Kim, Mark L. Cohen, Brian S. Appleby, Christopher A. Walsh, Jiri G. Safar, August Yue Huang and Michael B. Miller | Summary: Creutzfeldt-Jakob Disease (CJD), the most common human prion disease, is associated […]


Continue.. Neuropathologically-directed profiling of PRNP somatic and germline variants in sporadic human prion disease

Unifying community-wide whole-brain imaging datasets enables robust automated neuron identification and reveals determinants of neuron positioning in C. elegans

Posted by dbos UCSF

Kavli Affiliate: Saul Kato | Authors: Daniel Yutaka Sprague, Kevin Rusch, Raymond L Dunn, Jackson Borchardt, Greg Bubnis, Grace Chiu, Chentao Wen, Ryoga Suzuki, Shivesh Chaudhary, Ben Dichter, Ryan Ly, Shuichi Onami, Hang Lu, Kotaro Kimura, Eviatar I Yemini and Saul Kato | Summary: We develop a data harmonization approach for C. elegans volumetric microscopy […]


Continue.. Unifying community-wide whole-brain imaging datasets enables robust automated neuron identification and reveals determinants of neuron positioning in C. elegans

Epistasis between N-terminal and receptor-binding domains drives cell entry in a bat coronavirus spike

Posted by dbos Rockefeller

Kavli Affiliate: Charles M. Rice | Authors: Alexandra L. Tse, Cory M. Acreman, Inna Ricardo-Lax, Jacob Berrigan, Gorka Lasso, Toheeb Balogun, Fiona L. Kearns, Lorenzo Casalino, Georgia L. McClain, Amartya Mudry Chandran, Charlotte Lemeunier, Rommie E. Amaro, Charles M. Rice, Rohit K. Jangra, Jason S. McLellan, Kartik Chandran and Emily Happy Miller | Summary: The […]


Continue.. Epistasis between N-terminal and receptor-binding domains drives cell entry in a bat coronavirus spike

Structure of the human K2P13.1(THIK-1) channel reveals a novel hydrophilic pore restriction and lipid cofactor site

Posted by dbos UCSF

Kavli Affiliate: Daniel Minor | Authors: Shatabdi Roy-Chowdhury, Seil Jang, Fayal Abderemane-Ali, Fiona Naughton, Michael Grabe and Daniel L Minor, Jr. | Summary: The halothane-inhibited K2P leak potassium channel K2P13.1 (THIK-1)1–3 is found in diverse cells1,4 including neurons1,5 and microglia6–8 where it affects surveillance6, synaptic pruning7, phagocytosis7, and inflammasome-mediated interleukin-1β release6,8,9. As with many K2Ps1,5,10–14 […]


Continue.. Structure of the human K2P13.1(THIK-1) channel reveals a novel hydrophilic pore restriction and lipid cofactor site

Senescent cell heterogeneity and responses to senolytic treatment are related to cell cycle status during cell growth arrest.

Posted by dbos Hopkins

Kavli Affiliate: Denis Wirtz | Authors: Francesco Neri, Shuyuan Zheng, Mark Watson, Pierre Yves Desprez, Akos Gerencser, Judith Campisi, Denis Wirtz, Pei-Hsun Wu and Birgit Schilling | Summary: Cellular senescence has been strongly linked to aging and age-related diseases. It is well established that the phenotype of senescent cells is highly heterogeneous and influenced by […]


Continue.. Senescent cell heterogeneity and responses to senolytic treatment are related to cell cycle status during cell growth arrest.

A multimodal fMRI dataset unifying naturalistic processes with a rich array of experimental tasks

Posted by dbos Hopkins

Kavli Affiliate: Martin Lindquist | Authors: Heejung Jung, Maryam Amini, Bethany J Hunt, Eilis I Murphy, Patrick Sadil, Yaroslav O Halchenko, Bogdan Petre, Zizhuang Miao, Philip A Kragel, Xiaochun Han, Mickela O Heilicher, Michael Sun, Owen G Collins, Martin A Lindquist and Tor D Wager | Summary: Cognitive neuroscience has advanced significantly due to the […]


Continue.. A multimodal fMRI dataset unifying naturalistic processes with a rich array of experimental tasks

TrkA+ sensory neurons regulate osteosarcoma proliferation and vascularization to promote disease progression

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: Aaron W. James, Qizhi Qin, Sowmya Ramesh, Zhao Li, Lingke Zhong, Masnsen Cherief, Mary Archer, Xin Xing, Neelima Thottappillil, Mario Gomez-Salazar, Manyu Zhu, Leslie Chang, Ankit Uniyal, Khadijah Mazhar, Monisha Mittal, Edward F. McCarthy, Carol D. Morris, Benjamin Levi, Yun Guan, Thomas L. Clemens and Theodore J. Price | […]


Continue.. TrkA+ sensory neurons regulate osteosarcoma proliferation and vascularization to promote disease progression

Suppression of astrocyte BMP signaling improves fragile X syndrome molecular signatures and functional deficits

Posted by dbos UCSD / Salk

Kavli Affiliate: Nicola Allen | Authors: James Deng, Lara Labarta-Bajo, Ashley N Brandebura, Samuel B Kahn, Antonio F M Pinto, Jolene K Diedrich and Nicola J Allen | Summary: Fragile X syndrome (FXS) is a monogenic neurodevelopmental disorder with manifestations spanning molecular, neuroanatomical, and behavioral changes. Astrocytes contribute to FXS pathogenesis and show hundreds of […]


Continue.. Suppression of astrocyte BMP signaling improves fragile X syndrome molecular signatures and functional deficits