Photothrombotic Ischemic Thalamic Stroke in Mice Recapitulates Spontaneous Pain Features of Central Post-Stroke Pain in Humans

Kavli Affiliate: Jeanne Paz | Authors: Jeremy B Ford, Olive N Tambou, Jarret AP Weinrich, Debleena Chatterjee, Allan Basbaum and Jeanne T. Paz | Summary: Central post-stroke pain (CPSP) is a highly distressing condition that develops in 50% of people who suffer a thalamic stroke, and is typically unresponsive to current clinical treatments. Hypoxic damage […]


Continue.. Photothrombotic Ischemic Thalamic Stroke in Mice Recapitulates Spontaneous Pain Features of Central Post-Stroke Pain in Humans

Synaptic plasticity of prefrontal long-range inhibition regulates cognitive flexibility

Kavli Affiliate: Vikaas Sohal | Authors: Xiyu Zhu, Lara L. Hagopian, Kira E. Wallquist and Vikaas Singh Sohal | Summary: While glutamatergic synaptic plasticity is believed to be a fundamental mechanism mediating learning, the behavioral significance of plasticity at cortical GABAergic synapses remains less well understood. Furthermore, despite recent discoveries of long-range projections from neocortical […]


Continue.. Synaptic plasticity of prefrontal long-range inhibition regulates cognitive flexibility

Ecological Factors Affecting Prosociality in Marmoset Monkeys

Kavli Affiliate: Cory Miller | Authors: Anand R Mysorekar, Anushka Vispute and Cory Miller | Summary: Prosocial behaviors, such as cooperation and food sharing, are critical for maintaining group cohesion in social species, yet the influence of transient physiological states on these behaviors remains poorly understood. This study investigates how short-term ecological factors impact social […]


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A cell-based scrambling assay reveals phospholipid headgroup preference of TMEM16F on the plasma membrane

Kavli Affiliate: Lily Jan and Yuh Nung Jan | Authors: Chin Fen Teo, Sami T Tuomivaara, Niek van Hilten, David Crottès, Yuh Nung Jan, Michael Grabe and Lily Y Jan | Summary: The asymmetric resting distribution of the three major phospholipid classes on the mammalian plasma membrane, with phosphatidylserine and phosphatidylethanolamine mostly on the inner […]


Continue.. A cell-based scrambling assay reveals phospholipid headgroup preference of TMEM16F on the plasma membrane

Humans share acoustic preferences with other animals

Kavli Affiliate: Sarah Woolley | Authors: Logan S James, Sarah C Woolley, Jon T Sakata, Courtney B Hilton, Michael J Ryan and Samuel A Mehr | Summary: Many animals produce sounds during courtship, and receivers prefer some sounds over others. Shared ancestry and convergent evolution may generate similarities in preference across species and could underlie […]


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Mapping the projectional architecture of the mouse midbrain dopaminergic system using cell type-specific barcoding

Kavli Affiliate: Justus M Kebschull | Authors: Hyopil Kim, Cheng Xu, Craig Washington, Maggie Lowmann and Justus M Kebschull | Summary: Brain-wide neural circuits are formed by the diverse axonal branching patterns of many individual neurons. Here we introduce POINTseq (projections of interest by sequencing), a high-throughput and user-friendly barcoded connectomics method that uses cell […]


Continue.. Mapping the projectional architecture of the mouse midbrain dopaminergic system using cell type-specific barcoding

Interpretable abstractions of artificial neural networks predict behavior and neural activity during human information gathering

Kavli Affiliate: Marcelo Mattar | Authors: Simone D’Ambrogio, Jan Grohn, Nima Khalighinejad, Marcelo Mattar, Laurence T Hunt and Matthew F Rushworth | Summary: It has been suggested that humans and other animals are driven by a fundamental desire to acquire information about opportunities available in their environments. Not only might such a desire explain pathological […]


Continue.. Interpretable abstractions of artificial neural networks predict behavior and neural activity during human information gathering

SLAy-ing oversplitting errors in high-density electrophysiology spike sorting

Kavli Affiliate: Adam S. Charles | Authors: Sai Koukuntla, Tate DeWeese, Alexandra Cheng, Robyn Mildren, Aamna Lawrence, Austin R Graves, Jennifer Colonell, Timothy D Harris and Adam S Charles | Summary: The growing channel count of silicon probes has substantially increased the number of neurons recorded in electrophysiology (ephys) experiments, rendering traditional manual spike sorting […]


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Immunoinformatics Approach to Engineer a Multi-Epitope Vaccine Against SdrG in Skin Commensal Staphylococcus epidermidis

Kavli Affiliate: Gabriel Silva | Authors: Shahina Akter, Gabriel Vinícius Rolim Silva, Jonas Ivan Nobre Oliveira, Umberto Laino Fulco, Xianyang Xu and Yu Vincent Fu | Summary: The human skin serves as a dynamic ecosystem for beneficial commensal bacteria such as Staphylococcus epidermidis, which play a crucial role in maintaining skin barrier integrity and modulating […]


Continue.. Immunoinformatics Approach to Engineer a Multi-Epitope Vaccine Against SdrG in Skin Commensal Staphylococcus epidermidis

Single Cell Proteomics in the Developing Human Brain

Kavli Affiliate: Arnold R. Kriegstein | Authors: Tianzhi Wu, lihua jiang, Tanzila Mukhtar, Li Wang, ruiqi jian, Cheng Wang, Tiffany Trinh, Arnold Kriegstein, Michael Snyder and Jingjing Li | Summary: Proteins are the functional effectors of virtually all biological processes, and accurately measuring their abundance and dynamics is essential for understanding development and disease. Although […]


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