Molecular and cellular dynamics of the developing human neocortex at single-cell resolution

Kavli Affiliate: Arturo Alvarez-Buylla Arnold R. Kriegstein Xin Duan | Authors: Li Wang, Cheng Wang, Juan A. Moriano, Songcang Chen, Guolong Zuo, Arantxa Cebrian-Silla, Shaobo Zhang, Tanzila Mukhtar, Shaohui Wang, Mengyi Song, Lilian G. de Oliveira, Qiuli Bi, Jonathan J. Augustin, Xinxin Ge, Mercedes F. Paredes, Eric J. Huang, Arturo Alvarez-Buylla, Xin Duan, Jingjing Li […]


Continue.. Molecular and cellular dynamics of the developing human neocortex at single-cell resolution

Humans use local spectrotemporal correlations to detect rising and falling pitch

Kavli Affiliate: Damon Clark | Authors: Parisa A Vaziri, Samuel D McDougle and Damon A Clark | Summary: To discern speech or appreciate music, the human auditory system detects how pitch increases or decreases over time. However, the algorithms used to detect changes in pitch, or pitch motion, are incompletely understood. Here, using psychophysics, computational […]


Continue.. Humans use local spectrotemporal correlations to detect rising and falling pitch

A microglia clonal inflammatory disorder in Alzheimer’s Disease

Kavli Affiliate: Damon Clark | Authors: Parisa A Vaziri, Samuel D McDougle and Damon A Clark | Summary: To discern speech or appreciate music, the human auditory system detects how pitch increases or decreases over time. However, the algorithms used to detect changes in pitch, or pitch motion, are incompletely understood. Here, using psychophysics, computational […]


Continue.. A microglia clonal inflammatory disorder in Alzheimer’s Disease

Spatial 3D genome organization controls the activity of bivalent chromatin during human neurogenesis

Kavli Affiliate: Arnold R. Kriegstein | Authors: Sajad Hamid Ahanger, Chujing Zhang, Evan R. Semenza, Eugene Gil, Mitchel A. Cole, Li Wang, Arnold R. Kriegstein and Daniel Lim | Summary: The nuclear genome is spatially organized into a three-dimensional (3D) architecture by physical association of large chromosomal domains with subnuclear compartments including the nuclear lamina […]


Continue.. Spatial 3D genome organization controls the activity of bivalent chromatin during human neurogenesis

Complete sequencing of ape genomes

Kavli Affiliate: Erich Jarvis | Authors: DongAhn Yoo, Arang Rhie, Prajna Hebbar, Francesca Antonacci, Glennis A. Logsdon, Steven J. Solar, Dmitry Antipov, Brandon D. Pickett, Yana Safonova, Francesco Montinaro, Yanting Luo, Joanna Malukiewicz, Jessica M. Storer, Jiadong Lin, Abigail N. Sequeira, Riley J. Mangan, Glenn Hickey, Graciela Monfort Anez, Parithi Balachandran, Anton Bankevich, Christine R. […]


Continue.. Complete sequencing of ape genomes

Mechanism of neurodegeneration mediated by clonal inflammatory microglia

Kavli Affiliate: Jean-Laurent Casanova | Authors: Rocio Vicario, Stamatina Fragkogianni, Maria Pokrovskii, Carina Mayer, Estibaliz Lopez-Rodrigo, Yang Hu, Masato Ogishi, Araitz Alberdi, Ann Baako, Oyku Ay, Isabelle Plu, Veronique Sazdovitch, Sebastien Heritier, Fleur Cohen-Aubart, Natalia Shor, Makoto Miyara, Florence Nguyen-Khac, Agnes Viale, Ahmed Idbaih, Zahir Amoura, Marc Rosenblum, Haochen Zhang, Elias-Ramzey Karnoub, Palash Sashittal, Akhil […]


Continue.. Mechanism of neurodegeneration mediated by clonal inflammatory microglia

Ciliary biology intersects autism and congenital heart disease

Kavli Affiliate: Jeremy Willsey | Authors: Nia Teerikorpi, Micaela C Lasser, Sheng Wang, Elina Kostyanovskaya, Ethel Bader, Nawei Sun, Jeanselle Dea, Tomasz J. Nowakowski, A Jeremy Willsey and Helen Willsey | Summary: Autism spectrum disorder (ASD) commonly co-occurs with congenital heart disease (CHD), but the molecular mechanisms underlying this comorbidity remain unknown. Given that children […]


Continue.. Ciliary biology intersects autism and congenital heart disease

Effects of ketamine on GABAergic and glutamatergic activity in the mPFC: biphasic recruitment of GABA function in antidepressant-like responses

Kavli Affiliate: Marina Picciotto | Authors: Manoela V Fogaca, Fernanda Daher and Marina Picciotto | Summary: Major depressive disorder (MDD) is associated with disruptions in glutamatergic and GABAergic activity in the medial prefrontal cortex (mPFC), leading to altered synaptic formation and function. Low doses of ketamine rapidly rescue these deficits, inducing fast and sustained antidepressant […]


Continue.. Effects of ketamine on GABAergic and glutamatergic activity in the mPFC: biphasic recruitment of GABA function in antidepressant-like responses

Calcium phosphate nanoclusters modify periodontium remodeling and minimize orthodontic relapse

Kavli Affiliate: Tejal Desai | Authors: Darnell L Cuylear, Moyu L Fu, Justin C Chau, Bhushan Kharbikar, Galateia Kazakia, Andrew Jheon, Stefan Habelitz, Sunil D Kapila and Tejal A Desai | Summary: Orthodontic relapse is one of the most prevalent concerns of orthodontic therapy. Relapse results in patients’ teeth reverting towards their pretreatment positions, which […]


Continue.. Calcium phosphate nanoclusters modify periodontium remodeling and minimize orthodontic relapse

Genetic Architecture and Analysis Practices of Circulating Metabolites in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

Kavli Affiliate: V. S. Ramachandran | Authors: Nannan Wang, Franklin P. Ockerman, Laura Y. Zhou, Megan L Grove, Taryn Alkis, John Barnard, Russell P. Bowler, Clary B. Clish, Shinhye Chung, Emily Drzymalla, Anne M. Evans, Nora Franceschini, Robert E. Gerszten, Madeline G. Gillman, Scott R. Hutton, Rachel S. Kelly, Charles Kooperberg, Martin G. Larson, Jessica […]


Continue.. Genetic Architecture and Analysis Practices of Circulating Metabolites in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program