Kavli Affiliate: Gaby Maimon | Authors: Franka H. van der Linden, Stephen C. Thornquist, Rick M. ter Beek, Jelle Y. Huijts, Mark A. Hink, Theodorus W.J. Gadella, Jr., Gaby Maimon and Joachim Goedhart | Summary: Fluorescent biosensors toggle between two states and for the vast majority of biosensors one state is bright and the other […]
Kavli Affiliate: Anirvan Nandy | Authors: Feng Xing, Alec Graham Sheffield, Monika P. Jadi, Steve W. C. Chang and Anirvan S. Nandy | Summary: Social communication relies on the ability to perceive and interpret the direction of others’ attention, and is commonly conveyed through head orientation and gaze direction in humans and nonhuman primates. However, […]
Kavli Affiliate: Keri Martinowich | Authors: Daianna Gonzalez-Padilla, Nicholas J. Eagles, Marisol Cano, Geo Pertea, Andrew E. Jaffe, Kristen R. Maynard, Dana B. Hancock, James T. Handa, Keri Martinowich and Leonardo Collado-Torres | Summary: Maternal smoking during pregnancy (MSDP) is associated with significant cognitive and behavioral effects on offspring. While neurodevelopmental outcomes have been studied […]
Kavli Affiliate: Laurent Younes and Michael Miller | Authors: Kaitlin Stouffer, Xiaoyin Chen, Hongkui Zeng, Benjamin Charlier, Laurent Younes, Alain Trouve and Michael I Miller | Summary: Advancements in imaging and molecular techniques enable the collection of subcellular-scale data. Diversity in measured features, resolution, and physical scope of capture across technologies and experimental protocols pose […]
Kavli Affiliate: Solange Brown, Loyal Goff, and Patrick Kanold | Authors: Su-Jeong Kim, Travis A. Babola, Kihwan Lee, Chanel J. Matney, Alina C. Spiegel, Michael H. Liew, Eva M. Schulteis, Austin E. Coye, Mikhail Proskurin, Hyunwook Kang, Julia A. Kim, Maxime Chevee, Kiwoong Lee, Patrick O. Kanold, Loyal A. Goff, Juhyun Kim and Solange P […]
Kavli Affiliate: Michael Miller | Authors: Mustansir Pindwarawala, Faiyaz A. K. Abid, Jaeeun Lee, Michael L. Miller, Juliet S. Noppers, Andrew P. Rideout and Melina A. Agosto | Summary: Summary: Synaptic transmission from photoreceptors to ON-bipolar cells (BCs) requires the postsynaptic metabotropic glutamate receptor mGluR6, located at BC dendritic tips. Binding of the neurotransmitter glutamate […]
Kavli Affiliate: Alexandra Nelson | Authors: Xiaowen Zhuang, Julia Lemak, Sadhana Sridhar and Alexandra B Nelson | Summary: Summary: Healthy action selection relies on the coordinated activity of striatal direct and indirect pathway neurons. In Parkinson’s disease (PD), in which loss of midbrain dopamine neurons is associated with progressive motor and cognitive deficits, this coordination […]
Kavli Affiliate: Alexandra Nelson | Authors: Emily L Twedell, Chloe J Bair-Marshall, Allison E Girasole, Lara K Scaria, Sadhana Sridhar and Alexandra B Nelson | Summary: Summary: Striatal medium spiny neurons (MSNs) integrate multiple external inputs to shape motor output. In addition, MSNs form local inhibitory synaptic connections with one another. The function of striatal […]
Kavli Affiliate: Alexandra Nelson | Authors: Rose B Creed, Scott C Harris, Sadhana Sridhar, Sascha du Lac, David S Zee, Felice A Dunn, Guy Bouvier and Alexandra B Nelson | Summary: Summary: Progressive supranuclear palsy (PSP) is a neurodegenerative disorder with an estimated prevalence of 5-7 people in 100,000. Clinically characterized by impairments in gait, […]
Kavli Affiliate: Michael Beer | Authors: Joseph F Hoff, Kirsty E Goudar, Michael Beer, Philip Hinchliffe, John M Shaw, Catherine L Tooke, Yuiko Takebayashi, Adrian J Mulholland, Christopher J Schofield and James Spencer | Summary: Carbapenemases, β-lactamases hydrolysing carbapenem antibiotics, severely challenge treatment of multi-drug resistant bacterial infections. OXA-48 is among the most widely disseminated […]