Kavli Affiliate: Denis Wirtz | Authors: pei-hsun wu, Denis Wirtz, Tiffany Chu, yeongseo lim and Yufei Sun | Summary: Cell migration plays a key role in normal developmental programs and in disease, including immune responses, tissue repair, and metastasis. Unlike other cell functions, such as proliferation which can be studied using high-throughput assays, cell migration […]
Kavli Affiliate: Patrick Kanold | Authors: Kate Maximov and Patrick O. Kanold | Summary: Presbycusis, or age-related hearing loss, is caused by changes in both the peripheral and the central auditory system. Many of the peripheral structures that degrade with age have been identified and characterized, but there is still a dearth of information pertaining […]
Kavli Affiliate: Denis Wirtz | Authors: pei-hsun wu, Denis Wirtz, Tiffany Chu, yeongseo lim and Yufei Sun | Summary: The accuracy of spatial gene expression profiles generated by probe-based in situ spatially-resolved transcriptomic technologies depends on the specificity with which probes bind to their intended target gene. Off-target binding, defined as a probe binding to […]
Kavli Affiliate: Kevin Bender | Authors: Joshua D Garcia, Chenyu Wang, Ryan Alexander, Emmie Banks, Timothy Fenton, Jean-Marc DeKeyser, Tatiana V Abramova, Alfred L George, Roy Ben-Shalom, David H Hackos and Kevin J Bender | Summary: Mature neocortical pyramidal cells functionally express two sodium channel (NaV) isoforms: NaV1.2 and NaV1.6. These isoforms are differentially localized […]
Kavli Affiliate: Attila Losonczy | Authors: Stephanie A Herrlinger, Jiayao Wang, Bovey Y Rao, Jonathan Chang, Joseph Gogos, Attila Losonczy and Dennis Vitkup | Summary: Neuropsychiatric disorders such as autism spectrum disorder (ASD) and schizophrenia (SCZ) share genetic risk factors, including rare high penetrance single nucleotide variants and copy number variants (CNVs), and exhibit both […]
Kavli Affiliate: David Kleinfeld | Authors: Abhi Aggarwal, Adrian Negrean, Yang Chen, Rishyashring Iyer, Daniel Reep, Anyi Liu, Anirudh Palutla, Michael E Xie, Bryan MacLennan, Kenta M Hagihara, Lucas W Kinsey, Julianna L Sun, Pantong Yao, Jihong Zheng, Arthur Tsang, Getahun Tsegaye, Yonghai Zhang, Ronak H Patel, Benjamin J Arthur, Julien Hiblot, Philipp Leippe, Miroslaw […]
Kavli Affiliate: Daeyeol Lee | Authors: John Bero IV, Colin Humphries, Yang Li, Aviral Kumar, Heungyeol Lee, Maxwell Shinn, John D. Murray, Timothy Vickery and Daeyeol Lee | Summary: Sensorimotor and cognitive abilities undergo substantial changes throughout the human lifespan, but the corresponding changes in the functional properties of cortical networks remain poorly understood. This […]
Kavli Affiliate: Ann McDermott | Authors: Chengming He, Nikhil R Varghese, Eric G Keeler, Chi L L Pham, Brayden Williams, Stephan Tetter, Crystal Semaan, Karyn L Wilde, Simon H J Brown, James C Bouwer, Yann Gambin, Emma Sierecki, Megan Steain, Margaret Sunde and Ann E McDermott | Summary: The formation of RIP-homotypic interaction motif (RHIM)-based […]
Kavli Affiliate: Erich Jarvis | Authors: Larissa S. Arantes, Tom Brown, Diego De Panis, Scott D. Whiting, Erin L. LaCasella, Gabriella A. Carvajal, Adam Kennedy, Deana Edmunds, Blair P. Bentley, Jennifer Balacco, Conor Whelan, Nivesh Jain, Tatiana Tilley, Brian O’Toole, Patrick Traore, Erich D. Jarvis, Oliver Berry, Peter H. Dutton, Lisa M. Komoroske and Camila […]
Kavli Affiliate: Kay Tye | Authors: Elizabeth Ransey, Gwenaëlle Thomas, Elias Wisdom, Agustin Almoril-Porras, Ryan Bowman, Elise Adamson, Kathryn K Walder-Christensen, Jesse A White, Dalton N Hughes, Hannah Schwennesen, Caly Ferguson, Kay Tye, Stephen D Mague, Long-Gang Niu, Zhao-Wen Wang, Daniel Colón-Ramos, Rainbo Hultman, Nenad Bursac and Kafui Dzirasa | Summary: Electrical signaling across distinct […]