RESPAN: A Deep Learning Pipeline for Accurate and Automated Restoration, Segmentation, and Quantification of Dendritic Spines

Posted by dbos Columbia

Kavli Affiliate: Franck Polleux | Authors: Sergio B. Garcia, Alexa P. Schlotter, Daniela Pereira, Aleksandra J Recupero, Franck Polleux and Luke A Hammond | Summary: Quantification of dendritic spines is essential for studying synaptic connectivity, yet most current approaches require manual adjustments or the combination of multiple software tools for optimal results. Here, we present […]


Continue.. RESPAN: A Deep Learning Pipeline for Accurate and Automated Restoration, Segmentation, and Quantification of Dendritic Spines

GeneCover: A Combinatorial Approach for Label-free Marker Gene Selection

Posted by dbos Hopkins

Kavli Affiliate: Donald Geman | Authors: An Wang, Stephanie C Hicks, Donald Geman and Laurent Younes | Summary: The selection of marker gene panels is critical for capturing the cellular and spatial heterogeneity in the expanding atlases of single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics data. Most current approaches to marker gene selection operate in […]


Continue.. GeneCover: A Combinatorial Approach for Label-free Marker Gene Selection

Control of tongue movements by the Purkinje cells of the cerebellum

Posted by dbos Hopkins

Kavli Affiliate: Reza Shadmehr | Authors: Paul Hage, Mohammad Amin Fakharian, Alden M. Shoup, Jay S Pi, Ehsan Sedaghat-Nejad, Simon P Orozco, In Kyu Jang, Vivian Looi, Toren Arginteanu and Reza Shadmehr | Summary: We use our tongue much like our hands: to interact with objects and transport them. For example, we use our hands […]


Continue.. Control of tongue movements by the Purkinje cells of the cerebellum

Viral-mediated Oct4 overexpression and inhibition of Notch signaling synergistically induce neurogenic competence in mammalian Muller glia.

Posted by dbos Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: Nguyet Le, Sherine Awad, Isabella Palazzo, Thanh Hoang and Seth Blackshaw | Summary: Retinal Müller glia in cold-blooded vertebrates can reprogram into neurogenic progenitors to replace neurons lost to injury, but mammals lack this ability. While recent studies have shown that transgenic overexpression of neurogenic bHLH factors and glial-specific […]


Continue.. Viral-mediated Oct4 overexpression and inhibition of Notch signaling synergistically induce neurogenic competence in mammalian Muller glia.

Daily ultrastructural remodeling of clock neurons

Posted by dbos UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Juan I. Ispizua, Micaela Rodriguez-Caron, Francisco J. Tassara, Kim Keun-young, Catalina Insusarry Perkins, Milagros Barzi, Christian Carpio-Romero, Celia N. Hansen, Julian Gargiulo, Ezio Rosato, Horacio de la iglesia, Mark Ellisman and M. Fernanda Ceriani | Summary: In Drosophila, about 250 clock neurons in the brain form a network that […]


Continue.. Daily ultrastructural remodeling of clock neurons

Circuit-Based Understanding of Fine Spatial Scale Clustering of Orientation Tuning in Mouse Visual Cortex

Posted by dbos Columbia

Kavli Affiliate: Kenneth Miller | Authors: Peijia Yu, Yuhan Yang, Olivia Gozel, Ian Oldenburg, Mario Dipoppa, Federico Rossi, Kenneth Miller, Hillel Adesnik, Na Ji and Brent Doiron | Summary: In sensory cortex of brain it is often the case that neurons are spatially organized by their functional properties. A hallmark of primary visual cortex (V1) […]


Continue.. Circuit-Based Understanding of Fine Spatial Scale Clustering of Orientation Tuning in Mouse Visual Cortex

Lineage plasticity of the integrated stress response is a hallmark of cancer evolution.

Posted by dbos UCSF

Kavli Affiliate: Peter Walter | Authors: Shiqi Diao, Jia Yi Zou, Shuo Wang, Nour Ghaddar, Jason E. Chan, Hyungdong Kim, Nicolas Poulain, Constantinos Koumenis, Maria Hatzoglou, Peter Walter, Nahum Sonenberg, John Le Quesne, Tuomas Tammela and Antonis E. Koromilas | Summary: The link between the “stress phenotype”-a well-established hallmark of cancer-and its role in tumor […]


Continue.. Lineage plasticity of the integrated stress response is a hallmark of cancer evolution.

Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy

Posted by dbos Columbia

Kavli Affiliate: Stefano Fusi | Authors: Lorenzo Posani, Shuqi Wang, Samuel Muscinelli, Liam Paninski and Stefano Fusi | Summary: A long-standing debate in neuroscience concerns whether individual neurons are organized into functionally distinct populations that encode information differently (“categorical” representations [1–3]) and the implications for neural computation. Here, we systematically analyzed how cortical neurons encode […]


Continue.. Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy

BLTP3A is associated with membranes of the late endocytic pathway and is an effector of CASM

Posted by dbos Yale

Kavli Affiliate: Pietro De Camilli | Authors: Michael G Hanna, Hely O Rodriguez Cruz, Kenshiro Fujise, Yumei Wu, C Shan Xu, Song Pang, Li Zhuoning, Mara Monetti and Pietro De Camilli | Summary: Recent studies have identified a family of rod-shaped proteins thought to mediate lipid transfer at intracellular membrane contacts by a bridge-like mechanism. […]


Continue.. BLTP3A is associated with membranes of the late endocytic pathway and is an effector of CASM

A vector calculus for neural computation in the cerebellum

Posted by dbos Hopkins

Kavli Affiliate: Reza Shadmehr | Authors: Mohammad Amin Fakharian, Alden Shoup, Paul Hage, Hisham Elseweifi and Reza Shadmehr | Summary: Null space theory predicts that a neuron will often generate spikes not to produce behavior, but to prevent another neuron’s impact on behavior. Here, we present a direct test of this theory in the brain. […]


Continue.. A vector calculus for neural computation in the cerebellum