A Scalable Toolkit for Modeling 3D Surface-based Brain Geometry

Kavli Affiliate: Anders Dale and Lisa T. Eyler | Authors: Yanghee Im, Leila Nabulsi, Melody J.Y. Kang, Sophia I. Thomopoulos, Ana M. Diaz Zuluaga, Anders M. Dale, Andriana Karuk, Annabella Di Giorgio, Benson Mwangi, Boris Gutman, Bronwyn Overs, Carlos Lopez Jaramillo, Colm McDonald, Dan Stein, Dara M. Cannon, David Glahn, Diego Hidalgo-Mazzei, Diliana Pecheva, Dominik […]


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Cell-type-selective synaptogenesis during the development of excitatory connectivity in the mammalian neocortex

Kavli Affiliate: Alex Kolodkin and Solange Brown | Authors: Alan Y. Gutman-Wei, Sriram Sudarsanam, Alec G. Cabalinan, Naseer Shahid, Anny Shi, Luis E. Guzman Clavel, Sophia M. Spindler-Krage, Amit Agarwal, Alex L. Kolodkin and Solange P. Brown | Summary: The function of mammalian neocortex relies on the timing of axon extension and establishment of cell-type-biased […]


Continue.. Cell-type-selective synaptogenesis during the development of excitatory connectivity in the mammalian neocortex

StCEL-based platform enables detection and sequencing of native sialoglycoRNA

Kavli Affiliate: Wei Min | Authors: Guang-Dong Zeng, Yun-Long Wang, Xu-Hui Chen, Yi Ma, Zhu Zhu, Huan-Lei Liu, Li-Yuan Fan, Hao Nan, Ziwaregul Nur, Min Wei, Xin-Yuan Liu, Li Yi, Jiu-Yu Jin, Yu-Song Cao, Meng-Bo Qiu, Wei-Peng Sun, Yang Bai, Quan-Bo Zhou, Guo-Qing Zhang, Jing-Feng Chen, Jie Shi, Jian Zheng, Yixuan Xie, Peng Li, Xiang-Bo […]


Continue.. StCEL-based platform enables detection and sequencing of native sialoglycoRNA

Perturb-seq reveals distinct responses to pluripotency regulator dosages underlying the control of self-renewal and differentiation

Kavli Affiliate: Michael Beer | Authors: Jielin Yan, Hyein S. Cho, Renhe Luo, Michael A. Beer, Wei Li and Danwei Huangfu | Summary: Precise regulation of transcription factor (TF) expression is critical for maintaining cell identity, but studies on how graded expression levels affect cellular phenotypes are limited. To address this gap, we employed human […]


Continue.. Perturb-seq reveals distinct responses to pluripotency regulator dosages underlying the control of self-renewal and differentiation

CK2 inhibition suppresses glial inflammation in the brain

Kavli Affiliate: Nicola Allen | Authors: Fred H Gage, Ioana I N Da Silva, Desiree Ramirez, Sarah L Parylak, Leslie A Wallace, James K Tucker, Joel M Erberich, Rutvi Katariya, Aidan H McDonald, Iryna S Gallina, Ariana L Tucker, Jillybeth Burgado, Baptiste N Jaeger, Jerika J Barron, Joshua M Pratt, Monique Pena, Vipula Racha, Christina […]


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Prefrontal gamma oscillations engage dynamic cell type-specific configurations to support flexible behavior

Kavli Affiliate: Vikaas Sohal | Authors: Aarron Justin Phensy, Lara Louise Hagopian, Caitriona M. Costello, Simon Haziza, Omkar Ghenand, Yanping Zhang, Mark J. Schnitzer and Vikaas Singh Sohal | Summary: Cognitive dysfunction in conditions such as schizophrenia involves disrupted communication between the prefrontal cortex (PFC) and mediodorsal thalamus (MD). Parvalbumin interneurons (PVI) are known to […]


Continue.. Prefrontal gamma oscillations engage dynamic cell type-specific configurations to support flexible behavior

Protein Structure Informed Bacteriophage Genome Annotation with Phold

Kavli Affiliate: Robert Edwards | Authors: George Bouras, Susanna R Grigson, Milot Mirdita, Michael Heinzinger, Bhavya Papudeshi, Vijini Mallawaarachchi, Renee Green, Rachel Seongeun Kim, Victor Mihalia, Alkis James Psaltis, Peter-John Wormald, Sarah Vreugde, Martin Steinegger and Robert A Edwards | Summary: Bacteriophage (phage) genome annotation is essential for understanding their functional potential and suitability for […]


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Modeling hidden cognitive states reveals acute and chronic effects of fentanyl on decision-making

Kavli Affiliate: Patricia Janak | Authors: Zhenlong Zhang, Patricia H. Janak and Eric Garr | Summary: The cognitive mechanisms underlying behavior are often dynamic, shifting gradually or abruptly over time scales spanning years, to weeks, to minutes. Whether drug-induced changes in learning and decision-making follow similarly dynamic patterns remains unclear. To address this, we apply […]


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Sequence termination cues drive habits via dopamine-mediated credit assignment

Kavli Affiliate: Patricia Janak | Authors: Robin Magnard, Yifeng Cheng, Joanna Zhou, Haley Province, Nathalie Thiriet, Patricia H Janak and Youna Vandaele | Summary: Background Mesolimbic dopamine (DA) neurons are central to cue guided reward seeking and action sequence learning. Yet, the mechanisms by which cue-induced DA neural activity drives goal-directed or habitual sequence execution […]


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Biliverdin Reductase A is a major determinant of neuroprotective Nrf2 signaling

Kavli Affiliate: Solomon Snyder | Authors: Chirag Vasavda, Ruchita Kothari, Navneet Ammal Kaidery, Suwran Chakraborty, Sunil Jamuna Tripathi, Ryan S Dhindsa, Samaneh Saberi, Julia E Lefler, Priyanka Kothari, Cristina Ricco, Kalyani Chaubey, Adele M Snowman, Michael C Ostrowski, Eugenio Barone, Lakshiminarayan M Iyer, L Aravind, Sudarshana M Sharma, Andrew A Pieper, Bobby Thomas, Solomon H […]


Continue.. Biliverdin Reductase A is a major determinant of neuroprotective Nrf2 signaling