Neuroscience – Page 2 – Kavli Institute Pre-Print Publications

mGluR4-Npdc1 complex mediates α-synuclein fibril-induced neurodegeneration

Posted by klaurent July 22, 2025July 28, 2025This Week: Neuroscience, Yale

Kavli Affiliate: Stephen Strittmatter | Authors: Azucena Perez-Canamas, Mingming Chen, Leire Almandoz-Gil, Nabab Khan, Si Jie Tang, Allyson Ho, Erik C Gunther and Stephen M. Strittmatter | Summary: Fibrils of misfolded α-synuclein (α-syn) accumulate in Parkinson’s disease and other synucleinopathies, spreading between cells to template further misfolding and drive neurodegeneration. α-syn fibril entry into healthy […]

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Blood-tumor barrier organoids recapitulate glioblastoma microenvironment and enable high-throughput modeling of therapeutic delivery

Posted by dbos July 22, 2025July 28, 2025Columbia, This Week: Neuroscience

Kavli Affiliate: Wei Min | Authors: Pei Zhuang, Benjamin Scott, Shuai Gao, Wei-Min Meng, Rui Yin, Xinyu Nie, Ludovica Gaiaschi, Sean E Lawler, Martine LM Lamfers, Fengfeng Bei and Choi-Fong Cho | Summary: The blood-brain barrier (BBB) is a highly specialized system that is critical for regulating transport between the blood and the central nervous […]

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Diet Processing and Nutrient Composition Drive Divergent Obesity Phenotypes in Wistar Rats

Posted by dbos July 22, 2025July 28, 2025This Week: Neuroscience, UCSD / Salk

Kavli Affiliate: Gabriel Silva | Authors: Pedro Rocha Tenorio, Gabriel Smolak Sobieski e Silva, Débora Hipólito Quadreli, Glaura Scantamburlo Alves Fernandes and Fábio Goulart de Andrade | Summary: Purpose This study aimed to investigate whether food processing, alone or combined with high-fat/high-sugar content, promotes obesity, metabolic syndrome (MtS), and oxidative stress in adult rats. Methods […]

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Mouse pups lacking a cerebral cortex develop abnormal vocal behavior

Posted by dbos July 22, 2025July 28, 2025Rockefeller, This Week: Neuroscience

Kavli Affiliate: Erich Jarvis | Authors: J. Lomax Boyd, Cesar Vargas and Erich D. Jarvis | Summary: Vocal learning is an essential component of spoken language and critically depends on the cerebral cortex. The evolutionary origins of cortical/pallial control over vocal learning abilities in mammals and songbirds remains largely unknown. For instance, reports conflict on […]

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Programmable microparticles rewire CAR signaling to enable super-physiological expansion of human T cells in vitro

Posted by dbos July 22, 2025July 28, 2025This Week: Neuroscience, UCSF

Kavli Affiliate: Tejal Desai | Authors: Qinghe Zeng, Landon Flemming, Yuanzhou Chen, Thomas Mazumder, Heinz Hammerlindl, Greg M. Allen, Ricardo Almeida, Jasper Z. Williams, Rogelio A. Hernandez-Lopez, Justin Eyquem, Chun Jimmie Ye, Wendell A Lim, Qizhi Tang, Tejal Desai and Xiao Huang | Summary: T cell proliferative capacity and persistence critically determine the therapeutic success […]

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Increased Exertion Variability is Linked to Disruptions in Effort Assessment in Multiple Sclerosis

Posted by dbos July 21, 2025July 28, 2025Hopkins, This Week: Neuroscience

Kavli Affiliate: Vikram Chib | Authors: Michael H Dryzer, Bardia Nourbakhsh, Jennifer Keller and Vikram S. Chib | Summary: Accurate assessment of exertion is crucial for determining whether to continue or rest during physical activity. Individuals with multiple sclerosis (MS) often report fatigue and motor impairments, yet the mechanisms underlying their assessments of effortful exertion […]

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Fold first, ask later: structure-informed function annotation of Pseudomonas phage proteins

Posted by dbos July 20, 2025July 28, 2025UCSF

Kavli Affiliate: Robert Edwards | Authors: Hannelore Longin, George Bouras, Susanna R. Grigson, Robert A. Edwards, Hanne Hendrix, Rob Lavigne and Vera van Noort | Summary: Phages, the viruses of bacteria, harbor an incredibly diverse repertoire of proteins capable of manipulating their bacterial hosts, inspiring many medical and biotechnological applications. However, to date, only a […]

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Dynamic convergence of autism disorder risk genes across neurodevelopment

Posted by dbos July 19, 2025July 28, 2025Yale

Kavli Affiliate: Vikaas Sohal | Authors: Cesar P Canales, Stephanie A Lozano, Nicholas A Frost, Karol Cichewicz, Wellington Amaral, Nicolas Seban, Ethan Fenton, Ayanna Wade, Nickolas Chu, Emily Smith, Cory Ardekani, Samuel Frank, Jeffrey Bennett, Pierre Lavenex, Aspen Kopley-Smith, Darlene Rahbarian, Melisa Corea, Daniela Perla, Liam Davis, Jiyuan Zhu, Rebecca Ortiz, Paris Beauregard, Sarah Morse, […]

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Genetically encoded assembly recorder temporally resolves cellular histories in cellulo and in vivo

Posted by dbos July 18, 2025July 28, 2025Hopkins

Kavli Affiliate: Dwight Bergles | Authors: Yuqing Yan, Jiaxi Lu, Zhe Li, Zuo-Han Zhao, Timothy F. Shay, Shunzhi Wang, Yaping Lei, Yimei Wang, Wei Chen, Patrick Parker, Hongru Yang, Aileen Qi, Yongzhi Sun, Dwight Bergles, David Baker and Dingchang Lin | Summary: Mapping cellular activity with high spatiotemporal precision in complex tissues is essential for […]

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A Rational Information Gathering Account of Infant Habituation

Posted by dbos July 18, 2025July 28, 2025UCSD / Salk

Kavli Affiliate: Marcelo Mattar | Authors: Gili Karni, Marcelo Mattar, Lauren Emberson and Nathaniel Douglass Daw | Summary: Gaze is one of the primary experimental measures for studying cognitive development, especially in preverbal infants. However, the field is only beginning to develop a principled explanatory framework for making sense of the various factors affecting gaze. […]

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