Single-cell long-read mRNA isoform regulation is pervasive across mammalian brain regions, cell types, and development

Posted by klaurent Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: Anoushka Joglekar, Wen Hu, Bei Zhang, Oleksandr Narykov, Mark Diekhans, Jennifer Balacco, Lishomwa Ndhlovu, Teresa A Milner, Olivier Fedrigo, Erich D Jarvis, Gloria M Sheynkman, Dmitry Korkin, Margaret Elizabeth Ross and Hagen U Tilgner | Summary: RNA isoforms influence cell identity and function. Until recently, technological limitations prevented a […]


Continue.. Single-cell long-read mRNA isoform regulation is pervasive across mammalian brain regions, cell types, and development

Lightning Pose: improved animal pose estimation via semi-supervised learning, Bayesian ensembling, and cloud-native open-source tools

Posted by klaurent Columbia

Kavli Affiliate: Liam Paninski, Nathaniel Sawtell | Authors: Dan Biderman, Matthew R Whiteway, Cole Hurwitz, Nicholas R Greenspan, Robert S Lee, Ankit Vishnubhotla, Michael Schartner, Julia M Huntenburg, Anup Khanal, Guido T Meijer, Jean-Paul Noel, Alejandro Pan-Vazquez, Karolina Z Socha, Anne E Urai, The International Brain Laboratory, Richard Warren, Dillon Noone, Federico Pedraja, John Cunningham, […]


Continue.. Lightning Pose: improved animal pose estimation via semi-supervised learning, Bayesian ensembling, and cloud-native open-source tools

Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease

Posted by klaurent Hopkins

Kavli Affiliate: Loyal Goff | Authors: Subhash Kulkarni, Monalee Saha, Jared Slosberg, Alpana Singh, Sushma Nagaraj, Laren S Becker, Chengxiu Zhang, Alicia Bukowski, Zhuolun Wang, Guosheng Liu, Jenna Leser, Mithra Kumar, Shriya Bakhshi, Matthew J Anderson, Mark Lewandoski, Elizabeth Vincent, Loyal Goff and Pankaj Jay Pasricha | Summary: The enteric nervous system (ENS), a collection […]


Continue.. Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease

High-throughput colocalization pipeline quantifies efficacy of mitochondrial targeting signals across different protein types

Posted by klaurent UCSF

Kavli Affiliate: Seth Shipman | Authors: Sierra K Lear, Jose A Nunez and Seth L Shipman | Summary: Efficient metabolic engineering and the development of mitochondrial therapeutics often rely upon the specific and strong import of foreign proteins into mitochondria. Fusing a protein to a mitochondria-bound signal peptide is a common method to localize proteins […]


Continue.. High-throughput colocalization pipeline quantifies efficacy of mitochondrial targeting signals across different protein types

Human Connectomes Are Heritable

Posted by klaurent Hopkins

Kavli Affiliate: Joshua Vogelstein | Authors: Jaewon Chung, Eric W Bridgeford, Michael Powell and Joshua T Vogelstein | Summary: The heritability of human connectomes is crucial for understanding the genetic and environmental factors that influence variations in connectomes, which can provide insights into behavior and disease. However, current approaches to studying connectome heritability assume an […]


Continue.. Human Connectomes Are Heritable

Studying of RNA-protein interactions between a mutant form of glycyl-tRNA synthetase associated with neurodegenerative diseases and IRES type I

Posted by klaurent Rockefeller

Kavli Affiliate: Ekaterina V. Vinogradova | Authors: Ekaterina Vinogradova, Alisa Mikhaylina, Oleg Nikonov and Ekaterina Nikonova | Summary: Aminoacyl-tRNA synthetases (aaRS) are the main enzymes of protein biosynthesis. Human glycyl-tRNA synthetase, in addition to the main function of amino acid transfer to the corresponding tRNA molecules, is also involved in the initiation of IRES I […]


Continue.. Studying of RNA-protein interactions between a mutant form of glycyl-tRNA synthetase associated with neurodegenerative diseases and IRES type I

A Universal Method for Crossing Molecular and Atlas Modalities using Simplex-Based Image Varifolds and Quadratic Programming

Posted by klaurent Hopkins

Kavli Affiliate: Laurent Younes, Michael Miller, Jean Fan | Authors: Kaitlin M Stouffer, Alain Trouve, Laurent Younes, Michael Kunst, Lydia Ng, Hongkui Zeng, Manjari Anant, Jean Fan, Yongsoo Kim and Michael I Miller | Summary: This paper explicates a solution to the problem of building correspondences between molecular-scale transcriptomics and tissue-scale atlases. The central model […]


Continue.. A Universal Method for Crossing Molecular and Atlas Modalities using Simplex-Based Image Varifolds and Quadratic Programming

SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signaling

Posted by klaurent UCSD / Salk

Kavli Affiliate: Jose Ricardo Suarez | Authors: Blanca Dies, Ana de Lucas-Rius, Laura Mendoza, Transito Garcia, Raul Fernandez, Jose Manuel Suarez, Fatima Milhano, Fernando Corrales, Natalia Redondo, Federica Pedrucci, Sara Zaldivar, Maria Angeles Jimenez, Maria Montoya and Juan Jose Garrido | Summary: SARS-CoV-2, the cause of the COVID19 pandemic, possesses eleven accessory proteins encoded in […]


Continue.. SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signaling

Activity-dependent subcellular compartmentalization of dendritic mitochondria structure in CA1 pyramidal neurons

Posted by klaurent Columbia

Kavli Affiliate: Franck Polleux | Authors: Daniel M Virga, Stevie Hamilton, Bertha Osei, Abigail Morgan, Emiliano Zamponi, Natalie J Park, Victoria L Hewitt, David Zhang, Kevin C Gonzalez, Erik Bloss, Franck Polleux and Tommy L Lewis, Jr. | Summary: Neuronal mitochondria play important roles beyond ATP generation, including Ca2+ uptake, and therefore have instructive roles […]


Continue.. Activity-dependent subcellular compartmentalization of dendritic mitochondria structure in CA1 pyramidal neurons

SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling

Posted by klaurent UCSF

Kavli Affiliate: Yuh Nung Jan, Lily Jan | Authors: Sami Tapio Tuomivaara, Chin Fen Teo, Yuh Nung Jan, Lily Y Jan and Arun Paul Wiita | Summary: To facilitate our understanding of the often rapid and nuanced dynamics of extracellularly exposed proteomes during signaling events, it is important to devise robust workflows affording fast time […]


Continue.. SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling