Single cell transcriptomic profiling of human brain organoids reveals developmental timing- and cell-type-specific vulnerabilities induced by NRXN1 CNVs in schizophrenia

Posted by klaurent Hopkins

Kavli Affiliate: Jin Kang | Authors: ChangHui Pak, Rebecca Sebastian, Kang Jin, Narciso Pavon, Ruby Bansal, Andrew Potter, Yoonjae Song, Juliana Babu, Rafael Gabriel, Yubing Sun and Bruce J Aronow | Summary: Abstract De novo mutations and copy number variations (CNVs) in NRXN1 (2p16.3) pose a significant risk for schizophrenia (SCZ). How NRXN1 CNVs impact […]


Continue.. Single cell transcriptomic profiling of human brain organoids reveals developmental timing- and cell-type-specific vulnerabilities induced by NRXN1 CNVs in schizophrenia

MicroRNA-218 instructs proper assembly of hippocampal networks

Posted by klaurent Rockefeller

Kavli Affiliate: Robert B. Darnell | Authors: Seth Taylor, Mariko Kobayashi, Antonietta Vilella, Durgesh Tiwari, Norjin Zolboot, Andrea Hartzell, Carol Girgiss, Yusuf Abaci, Claudia De Sanctis, Gian Carlo Bellenchi, Robert B Darnell, Christina Gross, Michele Zoli, Darwin K Berg and Giordano Lippi | Summary: ABSTRACT The assembly of the mammalian brain is orchestrated by temporally […]


Continue.. MicroRNA-218 instructs proper assembly of hippocampal networks

Human anti-ACE2 monoclonal antibodies as pan-sarbecovirus prophylactic agents

Posted by klaurent Rockefeller

Kavli Affiliate: Charles Rice | Authors: Fengwen Zhang, Jesse Jenkins, Renan V.H. de Carvalho, Sandra Nakandakari-Higa, Teresia Chen, Morgan E Abernathy, Elisabeth Nyakatura, David Andrew, Irina V. Lebedeva, Ivo C Lorenz, H.-Heinrich Hoffmann, Charles M. Rice, Gabriel D. Victora, Christopher O. Barnes, Theodora Hatziioannou and Paul D Bieniasz | Summary: Abstract Human monoclonal antibodies from […]


Continue.. Human anti-ACE2 monoclonal antibodies as pan-sarbecovirus prophylactic agents

Age-dependent changes in the dynamic functional organization of the brain at rest – a cross – cultural replication approach

Posted by klaurent Hopkins

Kavli Affiliate: David Linden | Authors: Xi Yang, Xinqi Zhou, Fei Xin, Benjamin Becker, David Linden and Dennis Hernaus | Summary: Abstract Age-associated changes in brain function play an important role in the development of neurodegenerative diseases. Although previous work has examined age-related changes in static functional connectivity (FC), accumulating evidence suggests that advancing age […]


Continue.. Age-dependent changes in the dynamic functional organization of the brain at rest – a cross – cultural replication approach

Peptaibol Production and Characterization from Trichoderma asperellum and their Action as Biofungicide.

Posted by klaurent UCSD / Salk

Kavli Affiliate: Jose Suarez Lopez | Authors: Pamela Alfaro-Vargas, Alisson Bastos-Salas, Rodrigo Muñoz-Arrieta, Reinaldo Pereira-Reyes, Mauricio Redondo-Solano, Julián Fernández, Aníbal Mora-Villalobos and José Pablo López-Gómez | Summary: Abstract Peptaibols (Paib), are a class of biologically active peptides isolated from soil, fungi and molds, which have interesting properties as antimicrobial agents. Paib production was optimized in […]


Continue.. Peptaibol Production and Characterization from Trichoderma asperellum and their Action as Biofungicide.

Alpha-synuclein pathology and reduced neurogenesis in the olfactory system affect olfaction in a mouse model of Parkinsons disease

Posted by klaurent Yale

Kavli Affiliate: Sreeganga Chandra | Authors: Eduardo Martin-Lopez, Charles A. GREER, Sreeganga Chandra, Vidyadhara D J, Teresa Liberia, Sarah J. Meller, Leah E. Harmon, Ryan M. Hsu, Kimberly Han and Betul Yucel | Summary: Abstract Parkinson’s Disease (PD) is characterized by multiple symptoms including olfactory dysfunction, whose underlying mechanisms remain unclear. Here, we explored pathological […]


Continue.. Alpha-synuclein pathology and reduced neurogenesis in the olfactory system affect olfaction in a mouse model of Parkinsons disease

Efficient meta-analysis of multivariate genome-wide association studies with Meta-MOSTest

Posted by klaurent UCSD / Salk

Kavli Affiliate: Anders Dale | Authors: Aihua Lin, alexey shadrin, Dennis van der Meer, Guy Hindley, Weiqiu Cheng, Ida Elken Sonderby, Shahram Bahrami, Kevin S OConnell, Zillur Rahman, Nadine Parker, Olav B Smeland, Chun Fan, Dominic Holland, Anders Dale, Ole Andreassen and Oleksandr Frei | Summary: Abstract Motivation Genome-wide association studies (GWAS) have been successful […]


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Arrestin-3 agonism at D3 dopamine receptors defines a subclass of second generation antipsychotics that promotes drug tolerance

Posted by klaurent UCSF

Kavli Affiliate: Kevin Bender | Authors: Selin Schamiloglu, Elinor Lewis, Anne C Hergarden, Kevin Bender and Jennifer L Whistler | Summary: ABSTRACT Second generation antipsychotics (SGAs) are front-line treatments for serious mental illness. Often, individual patients benefit only from some SGAs and not others. The mechanisms underlying this unpredictability in treatment efficacy remain unclear. All […]


Continue.. Arrestin-3 agonism at D3 dopamine receptors defines a subclass of second generation antipsychotics that promotes drug tolerance

Internal states as a source of subject-dependent movement variability and their representation by large-scale networks

Posted by klaurent Hopkins

Kavli Affiliate: Kathleen Cullen & Sridevi Sarma | Authors: Macauley Smith Breault, Pierre Sacré, Zachary B Fitzgerald, John T Gale, Kathleen E Cullen, Jorge A González-Martínez and Sridevi V Sarma | Summary: Abstract A human’s ability to adapt and learn relies on reflecting on past performance. Such reflections form latent factors called internal states that […]


Continue.. Internal states as a source of subject-dependent movement variability and their representation by large-scale networks

A thermodynamically-consistent model for ATP production in mitochondria

Posted by klaurent UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: Guadalupe C. Garcia, Thomas M. Bartol, Jr., Terrence J. Sejnowski and Padmini Rangamani | Summary: Abstract Life is based on energy conversion. In the nervous system, in particular, significant amounts of energy are needed to maintain synaptic transmission and homeostasis. To a large extent, neurons depend on oxidative phosphorylation […]


Continue.. A thermodynamically-consistent model for ATP production in mitochondria