Senescence-Linked Fibrosis in the Aging Human Ovary Revealed by p16-Based Histological Profiling and Spatial Transcriptomics

Kavli Affiliate: Denis Wirtz | Authors: Mark A Watson, Pooja Raj Devrukhkar, Natalia F Murad, Fan Wu, Moo J Kim, Hannah Anvari, Uyen Tran, Nicolas Martin, Tommy Tran, Giuliana Zaza, Kevin Schneider, Bikem Soygur, Elisheva D Shanes, Denis Wirtz, MaryEllen G Pavone, Simon Melov, Pei-Hsun Wu, David Furman, Francesca E Duncan and Birgit Schilling | […]


Continue.. Senescence-Linked Fibrosis in the Aging Human Ovary Revealed by p16-Based Histological Profiling and Spatial Transcriptomics

Structured Joint Decomposition (SJD) identifies shared dynamics across collections of biologically related multi-omics data matrices

Kavli Affiliate: Brian Caffo | Authors: Huan Chen, Guangyan Li, Jinrui Liu, Shreyash Sonthalia, Genevieve Stein-OBrien, Luo Xiao, Brian Caffo and Carlo Colantuoni | Summary: It is necessary to develop exploratory tools to learn from the unprecedented volume of high-dimensional multi-omic data currently being produced across the field of biomedicine. We have developed an R […]


Continue.. Structured Joint Decomposition (SJD) identifies shared dynamics across collections of biologically related multi-omics data matrices

The long noncoding RNA Peanut (Gm11454) promotes neurogenesis and rod photoreceptor differentiation during postnatal retinal development.

Kavli Affiliate: Seth Blackshaw | Authors: Jade Enright Hostetler, Fion Shiau, Xiaodong Zhang, Shiming Chen, Philip A Ruzycki, Seth Blackshaw and Brian Clark | Summary: Long noncoding RNAs (lncRNAs) display pervasive expression and function in the developing nervous system. Temporal profiling of gene expression in the retina has demonstrated differential expression of lncRNAs throughout development; […]


Continue.. The long noncoding RNA Peanut (Gm11454) promotes neurogenesis and rod photoreceptor differentiation during postnatal retinal development.

Mapping spatial gradients in spatial transcriptomics data with score matching

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Laurent Younes | Authors: An Wang, Donald Geman, Uthsav Chitra and Laurent Younes | Summary: Spatial transcriptomics (ST) technologies measure gene expression at thousands of locations within a two-dimensional tissue slice, enabling the study of spatial gene expression patterns. Spatial […]


Continue.. Mapping spatial gradients in spatial transcriptomics data with score matching

STcompare: comparative spatial transcriptomics data analysis of structurally matched tissues to characterize differentially spatially patterned genes

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Jean Fan | Authors: Kalen Clifton, Vivien Jiang, Rafael dos Santos Peixoto, Srujan Singh, Ryo Matsuura, Hamid Rabb and Jean Fan | Summary: Comparative analysis of spatial transcriptomics (ST) data is needed to identify genes that spatially change in their […]


Continue.. STcompare: comparative spatial transcriptomics data analysis of structurally matched tissues to characterize differentially spatially patterned genes

Sex and experience dependent regulation of synaptic protein turnover

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Richard Huganir | Authors: Seok Heo, Shiyu Zhang, Dong-Gi Mun, Akhilesh Pandey, Alexei M Bygrave and Richard L. Huganir | Summary: Synaptic transmission can be carefully tuned through plasticity mechanisms that regulate synaptic strength, structure, and number. In vivo measurements […]


Continue.. Sex and experience dependent regulation of synaptic protein turnover

APOE E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Keri Martinowich | Authors: Louise A. Huuki-Myers, Heena R. Divecha, Svitlana V. Bach, Madeline R. Valentine, Nicholas J. Eagles, Bernard Mulvey, Rahul A. Bharadwaj, Ruth Zhang, James R. Evans, Melissa Grant-Peters, Ryan A. Miller, Joel E. Kleinman, Shizhong Han, Thomas […]


Continue.. APOE E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex

CUSP: Complex Spike Sorting from Multi-electrode Array Recordings with U-net Sequence-to-Sequence Prediction

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Kathleen Cullen | Authors: Chenhao Bao, Robyn Mildren, Adam Charles and Kathleen E Cullen | Summary: Background Complex spikes (CSs) in cerebellar Purkinje cells convey unique signals complementary to Simple spike (SS) action potentials, but are infrequent and variable in […]


Continue.. CUSP: Complex Spike Sorting from Multi-electrode Array Recordings with U-net Sequence-to-Sequence Prediction

Visual landmark coding and dynamic coupling with path integration circuits in area 29e of the rodent parahippocampal cortex

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: James Knierim | Authors: Gorkem Secer, Bharath Krishnan, Noah Cowan and James J Knierim | Summary: The brain relies on external landmarks to anchor internal spatial representations. The neural mechanisms underlying this process and the sources of landmark signals remain […]


Continue.. Visual landmark coding and dynamic coupling with path integration circuits in area 29e of the rodent parahippocampal cortex

A disrupted compartment boundary underlies abnormal cardiac patterning and congenital heart defects

Kavli Affiliate: Denis Wirtz | Authors: Irfan S Kathiriya, Martin H Dominguez, Kavitha S Rao, Jonathon M. Muncie-Vasic, W. Patrick Devine, Kevin M. Hu, Swetansu K Hota, Bayardo I Garay, Diego Quintero, Piyush Goyal, Megan N Matthews, Reuben Thomas, Tatyana Sukonnik, Dario Miguel-Perez, Sarah Winchester, Emily F Brower, AndrĂ© Forjaz, Pei-Hsun Wu, Denis Wirtz, Ashley […]


Continue.. A disrupted compartment boundary underlies abnormal cardiac patterning and congenital heart defects