Kavli Affiliate: Justus M Kebschull, Michael Miller, Jean Fan | Authors: Kalen Clifton, Manjari Anant, Gohta Aihara, Lyla Atta, Osagie K Aimiuwu, Justus M Kebschull, Michael I Miller, Daniel Tward and Jean Fan | Summary: Spatial transcriptomics (ST) technologies enable high throughput gene expression characterization within thin tissue sections. However, comparing spatial observations across sections, […]
Kavli Affiliate: Seth Blackshaw | Authors: WPin Lyu, Maria Iribarne, Dmitri Serjanov, Yijie Zhai, Thanh Hoang, Leah J. Campbell, Patrick Boyd, Isabella Palazzo, Mikiko Nagashima, Nicholas J. Silva, Peter F. HItchcock, Jiang Qian, David R. Hyde and Seth Blackshaw | Summary: Following acute retinal damage, zebrafish possess the ability to regenerate all neuronal subtypes. This […]
Kavli Affiliate: Alex Kolodkin | Authors: James Kenneth Kiraly, Scott C Harris, Timour Al-Khindi, Felice Dunn and Alex L Kolodkin | Summary: The study of murine behavioral responses to visual stimuli is a key component of understanding mammalian visual circuitry. One notable response is the optokinetic reflex (OKR), a highly conserved innate behavior necessary for […]
Kavli Affiliate: Richard Huganir | Authors: Yoichi Araki, Kacey E Rajkovich, Elizabeth E Gerber, Timothy R Gamache, Richard C Johnson, Thanh Hai Tran, Bian Liu, Ingie Hong, Alfredo Kirkwood and Richard L Huganir | Summary: SynGAP is an abundant synaptic GTPase-activating protein (GAP) critical for synaptic plasticity, learning, memory, and cognition. Mutations in SYNGAP1 in […]
Kavli Affiliate: Patricia Janak | Authors: Robin Magnard, Maxime Fouyssac, Yvan M Vachez, Yifeng Cheng, Thibault Dufourd, Carole Carcenac, sabrina Boulet, Patricia H Janak, Marc Savasta, David Belin and Sebastien Carnicella | Summary: Impulse control disorders (ICDs), a wide spectrum of maladaptive behavior which includes pathological gambling, hypersexuality and compulsive buying, have been recently suggested […]
Kavli Affiliate: Michael Beer | Authors: Jessica D. Resnick, Jo L. Wilson, Eddy Anaya, Abigail Conte, Maggie Li, William Zhong, Michael A. Beer and Andrew Pekosz | Summary: Primary differentiated human epithelial cell cultures have been widely used by researchers to study viral fitness and virus-host interactions, especially during the COVID19 pandemic. These cultures recapitulate […]
Kavli Affiliate: Brian Caffo, Joshua Vogelstein | Authors: Eric W. Bridgeford, Michael Powell, Gregory Kiar, Stephanie Noble, Jaewon Chung, Sambit Panda, Ross Lawrence, Ting Xu, Michael Milham, Brian Caffo and Joshua T. Vogelstein | Summary: Batch effects, undesirable sources of variance across multiple experiments, present significant challenges for scientific and clinical discoveries. Specifically, batch effects […]
Kavli Affiliate: Adam S. Charles | Authors: Ahmed El Hady, Daniel Y Takahashi, Ruolan Sun, Oluwateniola Akinwale, Tyler Boyd-Meredith, Yisi Zhang, Adam Charles and Carlos Brody | Summary: Functional ultrasound imaging (fUS) is an emerging imaging technique that indirectly measures neural activity via changes in blood volume. To date it has not been used to […]
Kavli Affiliate: David Linden | Authors: Suvarnalata Xanthate Duggirala, Michael Schwartze, Lisa K Goller, David E.J. Linden, Ana Pinheiro and Sonja A Kotz | Summary: Background: Sensory suppression occurs when hearing ones self-generated voice, as opposed to passively listening to ones own voice. Quality changes of sensory feedback to the self-generated voice can increase attentional […]
Kavli Affiliate: Denis Wirtz | Authors: Wenxuan Du, Jingyi Zhu, Yufei Wu, Ashley Kiemen, Sean Sun and Denis Wirtz | Summary: Matrix stiffness and corresponding mechano-signaling play indispensable roles in cellular phenotypes and functions. How tissue stiffness influences the behavior of monocytes, a major circulating leukocyte of the innate system, and how it may promote […]