Kavli Affiliate: Kristina Nielsen Loyal Goff | Authors: Soraia Barao, Yijun Xu, Rachel Vistein, Loyal Goff, Kristina Nielsen, Byoung-Il Bae, Richard S. Smith, Christopher A Walsh, Genevieve Stein O Brien and Ulrich Muller | Summary: The mammalian neocortex differs vastly in size and complexity between mammalian species, yet the mechanisms that lead to an increase […]
Kavli Affiliate: Jean Fan | Authors: Jude Marvin Phillip, Pratik Kamat, Nico Macaluso, Chanhong Min, Yukang Li, Anshika Agrawal, Aaron Winston, Lauren Pan, Bartholomew Marvin Starich, Teasia Stewert, Pei-Hsun Wu, Jean Fan and Jeremy Walston | Summary: Cellular senescence is an established driver of aging, exhibiting context-dependent phenotypes across multiple biological length-scales. Despite its mechanistic […]
Kavli Affiliate: Joshua Vogelstein | Authors: Jaewon Chung, Eric W Bridgeford, Michael Powell, Derek Pisner, Ting Xu and Joshua T Vogelstein; | Summary: A complete understanding of human behavior and disease depends upon our ability to parse genetic and environmental influences in the human brain. The heritability of a trait quantifies the degree of its […]
Kavli Affiliate: Keri Martinowich | Authors: Anthony Dial Ramnauth, Madhavi Tippani, Heena R. Divecha, Alexis R. Papariello, Ryan A Miller, Erik D Nelson, Elizabeth A. Pattie, Joel E. Kleinman, Kristen R. Maynard, Leonardo Collado-Torres, Thomas M. Hyde, Keri Martinowich, Stephanie C Hicks and Stephanie Cerceo Page | Summary: The dentate gyrus of the hippocampus is […]
Kavli Affiliate: Hey-Kyoung Lee and Patrick Kanold | Authors: Peter Jendrichovsky, Hey-Kyoung Lee and Patrick O Kanold | Summary: Plastic changes in the brain are primarily limited to early postnatal periods. Recovery of adult brain plasticity is critical for the effective development of therapies. A brief (1-2 week) duration of visual deprivation (dark exposure, DE) […]
Kavli Affiliate: Michael Beer | Authors: Michael Beer, Ana Sofia F. Oliveira, Catherine L. Tooke, Philip Hinchliffe, Angie Tsz Yan Li, Balazs Balega, James Spencer and Adrian J Mulholland | Summary: β-Lactamases, which hydrolyse β-lactam antibiotics, are key determinants of antibiotic resistance. Predicting the sites and effects of distal mutations in enzymes is challenging. For […]
Kavli Affiliate: Jeremias Sulam | Authors: Zhenzhen Wang, Cesar A. Santa-Maria, Aleksander S. Popel and Jeremias Sulam | Summary: The tumor microenvironment is widely recognized for its central role in driving cancer progression and influencing prognostic outcomes. Despite extensive research efforts dedicated to characterizing this complex and heterogeneous environment, considerable challenges persist. In this study, […]
Kavli Affiliate: Keri Martinowich | Authors: Robert A Phillips III, Seyun Oh, Svitlana V Bach, Yufeng Du, Ryan A Miller, Joel E Kleinman, Thomas M Hyde, Stephanie C Hicks, Stephanie Cerceo Page and Keri Martinowich | Summary: The lateral septum (LS) is a midline, subcortical structure, which regulates social behaviors that are frequently impaired in […]
Kavli Affiliate: Denis Wirtz | Authors: Devon E Mason, Megan Goeckel, Sebastian L Vega, Pei-Hsun Wu, Dymonn Johnson, Su-Jin Heo, Denis Wirtz, Jason A Burdick, Levi Wood, Brain Y Chow, Amber N Stratman and Joel D Boerckel | Summary: Vascular morphogenesis requires persistent endothelial cell motility that is responsive to diverse and dynamic mechanical stimuli. […]
Kavli Affiliate: Brian Caffo Randal Burns Carey Priebe Joshua Vogelstein | Authors: Jaewon Chung, Ross Lawrence, Alexander Loftus, Gregory Kiar, Eric Bridgeford, Consortium for Reliability and Reproducibility, Vikram Chandrashekhar, Disa Mhembere, Sephira Ryman, Xi-Nian Zuo, Daniel Margulies, R. Cameron Craddock, Carey E. Priebe, Rex Jung, Vince D. Calhoun, Brian Caffo, Randal Burns, Michael P. Milham […]