Mobius Assembly for Plant Systems highlights promoter-coding sequence terminator interaction in gene regulation

Kavli Affiliate: Andreas Andreou | Authors: Elif Gediz Kocaoglan, Andreas Andreou, Jessica Nirkko, Marisol Ochoa-Villarreal, Gary Loake and Naomi Nakayama | Summary: Plants are the primary biological platforms for producing food, energy, and materials in agriculture; however, they remain a minor player in the recent synthetic biology-driven transformation in bioproduction. Molecular tools and technologies for […]


Continue.. Mobius Assembly for Plant Systems highlights promoter-coding sequence terminator interaction in gene regulation

Altered development and network connectivity in a human neuronal model of 15q11.2 deletion-related neurodevelopmental disorders

Kavli Affiliate: Dwight Bergles | Authors: Christa Whelan Habela, Shiyu Liu, Arens Taga, Raha Dastgheyb, Norman Haughey, Dwight E Bergles, Hongjun Song, Guo-Li Ming and Nicholas J. Maragakis | Summary: The chromosome 15q11.2 locus is deleted in 1.5% of patients with genetic epilepsy and confers a risk for intellectual disability and schizophrenia. Individuals with this […]


Continue.. Altered development and network connectivity in a human neuronal model of 15q11.2 deletion-related neurodevelopmental disorders

Heterogeneous responses to embryonic critical period perturbations among different components of the Drosophila larval locomotor circuit

Kavli Affiliate: Michael Miller | Authors: Niklas Krick, Jacob Davies, Bramwell Coulson, Daniel Sobrido-Camean, Michael Miller, Matthew C.W. Oswald, Aref Arzan Zarin, Richard Baines and Matthias Landgraf | Summary: As developing neural circuits become functional, they undergo a phase of heightened plasticity in response to intrinsic and/or extrinsic stimuli. These developmental windows are termed critical […]


Continue.. Heterogeneous responses to embryonic critical period perturbations among different components of the Drosophila larval locomotor circuit

Characterizing cell-type spatial relationships across length scales in spatially resolved omics data

Kavli Affiliate: Jean Fan | Authors: Rafael dos Santos Peixoto, Brendan F Miller, Maigan A Brusko, Gohta Aihara, Lyla Atta, Manjari Anant, Mark A Atkinson, Todd M Brusko, Clive H Wasserfall and Jean Fan | Summary: Spatially resolved omics (SRO) technologies enable the identification of cell types while preserving their organization within tissues. Application of […]


Continue.. Characterizing cell-type spatial relationships across length scales in spatially resolved omics data

Time-on-task-related decrements in performance in the rodent continuous performance test are not caused by physical disengagement from the task

Kavli Affiliate: Keri Martinowich | Authors: Ye Li, Thomas van Kralingen, Megan Masi, Brandon Villaneuva Sanchez, Beyonca Mitchell, Joshua Johnson, Jorge Miranda-Barrientos, Jason J Rehg, Keri Martinowich and Gregory V Carr | Summary: Attention deficits, a hallmark of many neuropsychiatric disorders, significantly impair quality of life and functional outcome for patients. Continuous Performance Tests (CPTs) […]


Continue.. Time-on-task-related decrements in performance in the rodent continuous performance test are not caused by physical disengagement from the task

Brain-wide mapping of oligodendrocyte organization and oligodendrogenesis across the murine lifespan

Kavli Affiliate: Dwight Bergles | Authors: Yu Kang T Xu, Abigail Bush, Ephraim Musheyev, Anya A Kim, Sen Zhang, Jaime Eugenin von Bernhardi, Jeremias Sulam and Dwight E Bergles | Summary: Insulating sheaths of myelin accelerate neuronal signaling in complex networks of the mammalian brain. In the CNS, myelin sheaths are exclusively produced by oligodendrocytes, […]


Continue.. Brain-wide mapping of oligodendrocyte organization and oligodendrogenesis across the murine lifespan

Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function

Kavli Affiliate: Kathleen Cullen | Authors: Kazuya Ono, Amandine Jarysta, Natasha C. Hughes, Alma Jukic, Hui Ho Vanessa Chang, Michael R Deans, Ruth Anne Eatock, Kathleen E Cullen, Katie S Kindt and Basile Tarchini | Summary: Otolith organs in the inner ear and neuromasts in the fish lateral-line harbor two populations of hair cells oriented […]


Continue.. Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function

Parallel genome-scale CRISPR-Cas9 screens uncouple human pluripotent stem cell identity versus fitness

Kavli Affiliate: Michael Beer | Authors: Bess P. Rosen, Qing V. Li, Hyein S. Cho, Dingyu Liu, Dapeng Yang, Sarah Graff, Jielin Yan, Renhe Luo, Nipun Verma, Jeyaram R. Damodaran, Hanuman T. Kale, Samuel J. Kaplan, Michael A. Beer, Simone Sidoli and Danwei Huangfu | Summary: Pluripotent stem cells are defined by their self-renewal capacity, […]


Continue.. Parallel genome-scale CRISPR-Cas9 screens uncouple human pluripotent stem cell identity versus fitness

Effects of connectivity hyperalignment (CHA) on estimated brain network properties: from coarse-scale to fine-scale

Kavli Affiliate: Martin Lindquist | Authors: Farzad V. Farahani, Mary Beth Nebel, Tor Wager and Martin A. Lindquist | Summary: Recent gains in functional magnetic resonance imaging (fMRI) studies have been driven by increasingly sophisticated statistical and computational techniques and the ability to capture brain data at finer spatial and temporal resolution. These advances allow […]


Continue.. Effects of connectivity hyperalignment (CHA) on estimated brain network properties: from coarse-scale to fine-scale

Solving the “Blind men and the elephant problem”: Additive deep learning of complex high dimensional models from partial faceted datasets

Kavli Affiliate: Denis Wirtz | Authors: Yufei Wu, Pei-Hsun Wu, Allison Chambliss, Denis Wirtz and Sean Sun | Summary: Summary: Biological systems are complex networks involving tens of thousands of interacting molecular components, and measurable biological functions are emerging properties of these complex networks. Many quantitative studies in biology attempt to connect biological function with […]


Continue.. Solving the “Blind men and the elephant problem”: Additive deep learning of complex high dimensional models from partial faceted datasets