Kavli Affiliate: Martin Lindquist | Authors: Yanxi Liu, Richard E. Harris, Daniel Clauw, Emine Bayman, Andrew Leroux and Martin A. Lindquist | Summary: Chronic pain is a widespread public health issue that imposes substantial health, emotional, and economic burdens on individuals and communities. Because pain is subjective and lacks objective biomarkers, it is typically measured […]
Kavli Affiliate: Denis Wirtz | Authors: Pei-Hsun Wu, Chongguang Jin, Tiffany Chu, Qiming Zhang and Denis Wirtz | Summary: Preclinical drug evaluation relies heavily on two-dimensional (2D) monolayer assays, which fail to recapitulate the structural and functional complexity of the tumor microenvironment and may therefore misrepresent therapeutic efficacy. Here, we present VITAL (Volumetric Imaging-based Toxicity […]
Kavli Affiliate: Jean Fan | Authors: Dee Velazquez, Caleb Hallinan, Roujin An, Kalen Clifton and Jean Fan | Summary: Motivation Imaging-based spatially resolved transcriptomics (imSRT) technologies provide high-throughput molecular-resolution spatial characterization of genes within cells. Conventional analysis methods to identify cell-types and states in imSRT data rely on gene count matrices derived from tallying the […]
Kavli Affiliate: Michael Beer | Authors: Michael Beer, Jim Spencer and Adrian J Mulholland | Summary: Carbapenems are the most potent β-lactams, key antibiotics for healthcare-associated infections by Gram-negative bacteria and evade hydrolysis by most β-lactamases; but are increasingly threatened by emergence of enzymes exhibiting hydrolytic activity towards them. Of the four recognised β-lactamase subclasses, […]
Kavli Affiliate: Keri Martinowich | Authors: Michael S. Totty, Svitlana V. Bach, Madeline R. Valentine, Madhavi Tippani, Sarah E. Maguire, Ishbel Del Rosario Alvia, Ryan A. Miller, Joel E. Kleinman, Kristen R. Maynard, Stephanie Cerceo Page, Thomas M. Hyde, Stephanie C. Hicks and Keri Martinowich | Summary: The amygdala is a central hub for emotional […]
Kavli Affiliate: Michael Miller | Authors: Evan Layher, Ivan Skelin, Chrystal M Reed, Jeffrey M Chung, Lisa M Bateman, Taufik A Valiante, Adam N Mamelak, Michael B Miller and Ueli Rutishauser | Summary: The decision criterion is foundational to theories of decision-making, yet little is known about its neural underpinnings. In memory-based decision making, the […]
Kavli Affiliate: Martin Lindquist | Authors: Yanxi Liu, Richard E. Harris, Daniel Clauw, Emine Bayman, Andrew Leroux and Martin A. Lindquist | Summary: Chronic pain is a widespread public health issue that imposes substantial health, emotional, and economic burdens on individuals and communities. Because pain is subjective and lacks objective biomarkers, it is typically measured […]
Kavli Affiliate: Jill Leutgeb | Authors: Li Yuan, Jiarui Wang, Xiaohe Li, Wenxi Li, Johnatan Aljadeff, Jill K Leutgeb and Stefan Leutgeb | Summary: The ability to retain information over tens of seconds is essential for carrying out many routine tasks. Recurrently connected circuits are thought to support memory over these timescales, yet how they […]
Kavli Affiliate: Martin Lindquist | Authors: Ke Bo, Martin Lindquist, Peter J Gianaros and Tor Wager | Summary: The amygdala is central to negative affect and a primary target of top-down regulation, yet its temporal dynamics remain poorly characterized. Most fMRI studies model stimulus-evoked amygdala activity with a canonical hemodynamic response function and collapse across […]
Kavli Affiliate: Maya Opendak | Authors: Cesar Medina, Pragney Deme, Vishal Win, Isabellah Nikitah, Isaac S McKie, Mingyuan Song, Maria Raudales, Elaina Regier, Emily Amsden, Pranali Bendale, Norman Haughey and Maya Opendak | Summary: Adverse early caregiving produces lasting changes in social behavior and increases vulnerability to psychiatric illness, yet the biological pathways through which […]