Kavli Affiliate: Alex Kolodkin | Authors: Stephanie L Sarbanes, Jakub Ziak, Alex L Kolodkin and Antonina Roll-Mecak | Summary: Microtubule dynamics regulation is critical for neuronal development, yet how neurons regulate tubulin levels remains poorly understood. Tetratricopeptide repeat domain 5 (TTC5) mediates the co-translational degradation of tubulin transcripts in response to excess soluble tubulin, a.k.a. […]

Kavli Affiliate: David Linden | Authors: Xuelei Wang, Jana Zweerings, Michael Lührs, Fengyu Cong, Klaus Mathiak, David E.J. Linden, Rainer Goebel, Assunta Ciarlo and David M. A. Mehler | Summary: Identifying informative voxels is a critical, yet challenging step in functional magnetic resonance imaging (fMRI), particularly for multivariate analyses involving multiple related conditions. Existing approaches […]

Kavli Affiliate: Keri Martinowich | Authors: Leslie Hassanein, Bernard Mulvey, Harris Blankenship, Margaret M Tish, Anu Korukonda, L Cameron Liles, Amanda L Sharpe, Jean-Francois Pare, Rosa Villalba, Xiangchuan Chen, Khan Hekmatyar, Jenny Yang, Daniel Huddleston, Seong Su Kang, Arielle Segal, Steven A Sloan, Keri Martinowich, Keqiang Ye, Joseph D Dougherty, Katharine E McCann, Yoland Smith, […]

Kavli Affiliate: Adam S. Charles | Authors: Anuththara Rupasinghe, Adam S Charles and Jonathan W Pillow | Summary: Neurons exhibit substantial trial-to-trial variability in response to repeated stimuli, posing a major challenge for understanding the information content of neural spike trains. In the visual cortex, responses show greater-than-Poisson variability, whose origins and structure remain unclear. […]

Kavli Affiliate: Michael Miller | Authors: Zinan Zhou, Lovelace J Luquette, Guanlan Dong, Junho Kim, Jayoung Ku, Kisong Kim, Nandini Ramesh, Mingyun Bae, Ann Caplin, Diane D Shao, Bezawit Sahile, Kow Essuman, Eitan Goodman, Michael B Miller, August Yue Huang, William J. Nathan, Andre Nussenzweig, Peter J Park, Clotilde Lagier-Tourenne, Eunjung Alice Lee and Christopher […]

Kavli Affiliate: Reza Shadmehr | Authors: Mohammad Amin Fakharian, Elijah A Taeckens, Alexander N Vasserman, Alden Shoup and Reza Shadmehr | Summary: We tend to think of neurons as either excitatory or inhibitory, but certain neurons chemically inhibit their downstream targets while electrically exciting their neighbors. For example, in the cerebellum, molecular layer interneurons (MLIs) […]

Kavli Affiliate: Dwight Bergles | Authors: Alexandra I Mot, Ying Li, Payam Dibaj, Iva D Tzvetanova, Ulrike C Gerwig, Tizibt A Bogale, Sandra Goebbels, Wiebke Möbius, Dwight E Bergles, Brett M Morrison, Jeffrey D Rothstein, Don W Cleveland, Julia M Edgar and Klaus-Armin Nave | Summary: Amyotrophic lateral sclerosis (ALS) is a highly debilitating and […]

Kavli Affiliate: Xingde Li | Authors: Yuanwei Xu, Hyeoncheol Park, Jason Li, Yuehan Liu, T. Mamie Lih, Chengyu Lee, Xingde Li and hui Zhan | Summary: Spatial proteomics aims to characterize proteome in situ with regional resolution, linking molecular states to tissue architecture and microenvironments. While recent advances have expanded our access to spatially resolved […]

Kavli Affiliate: Martin Lindquist | Authors: Li-Bo Zhang, Amin Dehghani, Li Hu, Patrick Sadil, Liz Losin, Martin Lindquist and Tor Wager | Summary: Neuroimaging studies typically assume that sensory properties are encoded in response magnitude within fixed neural populations. However, this approach does not capture changes in the spatial extent of activation topography, despite growing […]

Kavli Affiliate: Keri Martinowich | Authors: Jiseok Lee, Hyunggyu Min, Cristine Casingal, Austin T Ledford, Hannah Lee, Won Ma, Yangzhenyu Gao, Hanqian Mao, Eric S McCoy, Lei Xing, Cindy Fang, Sang Ho Kwon, Mark J Zylka, Keri Martinowich, Kristen R Maynard, Stephanie C Hicks, E S Anton and Hyejung Won | Summary: Schizophrenia (SCZ) is […]