A multiscale functional map of somatic mutations in cancer integrating protein structure and network topology

Posted by dbos Hopkins

Kavli Affiliate: Jin Kang | Authors: Yingying Zhang, Alden K Leung, Jin Joo Kang, Yu Sun, Guanxi Wu, Le Li, Jiayang Sun, Lily Cheng, Tian Qiu, Junke Zhang, Shayne Wierbowski, Shagun Gupta, James Booth and Haiyuan Yu | Summary: A major goal of cancer biology is to understand the mechanisms underlying tumorigenesis driven by somatically […]


Continue.. A multiscale functional map of somatic mutations in cancer integrating protein structure and network topology

Single cell multiome profiling of pancreatic islets reveals physiological changes in cell type-specific regulation associated with diabetes risk

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Hannah Mummey, Weston Elison, Katha Korgaonkar, Ruth Elgamel, Parul Kudtarkar, Emily Griffin, Paola Benaglio, Michael Miller, Alokkumar Jha, Jocelyn E Manning Fox, Mark Mccarthy, Sebastian Preissl, Anna L Gloyn, Patrick E Macdonald and Kyle J Gaulton | Summary: Physiological variability in pancreatic cell type gene regulation and the impact […]


Continue.. Single cell multiome profiling of pancreatic islets reveals physiological changes in cell type-specific regulation associated with diabetes risk

3D histology reveals that immune response to pancreatic precancers is heterogeneous and depends on global pancreas structure

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Kavli Affiliate: Denis Wirtz | Authors: Ashley L Kiemen, Cristina Almagro Perez, Valentina Matos Romero, André Forjaz, Alicia M Braxton, Lucie Dequiedt, Jeeun Parksong, Courtney D Cannon, Xuan Yuan, Sarah M Shin, Jaanvi Mahesh Babu, Elizabeth D Thompson, Toby C Cornish, Won Jin Ho, Laura D Wood, PeiHsun Wu, Arrate Munoz-Barrutia, Ralph H Hruban and […]


Continue.. 3D histology reveals that immune response to pancreatic precancers is heterogeneous and depends on global pancreas structure

Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus

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Kavli Affiliate: Keri Martinowich | Authors: Alexa F Iannitelli, Leslie Hassanein, Bernard Mulvey, Harris Blankenship, L Cameron Liles, Amanda L Sharpe, Jean-Francois Pare, Arielle Segal, Steven A Sloan, Keri Martinowich, Katharine E McCann, Joseph D Dougherty, Yoland Smith, Michael J Beckstead and David Weinshenker | Summary: The locus coeruleus (LC), the major source of norepinephrine […]


Continue.. Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus

Hierarchical gradients of multiple timescales in the mammalian forebrain

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Kavli Affiliate: Daeyeol Lee | Authors: Min Song, Eun Ju Shin, Hyojung Seo, Alireza Soltani, Nicholas A Steinmetz, Daeyeol Lee, Min Whan Jung and Se-Bum Paik | Summary: Many anatomical and physiological features of cortical circuits, ranging from the biophysical properties of synapses to the connectivity patterns among different neuron types, exhibit consistent variation along […]


Continue.. Hierarchical gradients of multiple timescales in the mammalian forebrain

Control of tongue movements by the Purkinje cells of the cerebellum

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Kavli Affiliate: Reza Shadmehr | Authors: Paul Hage, Mohammad Amin Fakharian, Alden M. Shoup, Jay S Pi, Ehsan Sedaghat-Nejad, Simon P Orozco, In Kyu Jang, Vivian Looi, Toren Arginteanu and Reza Shadmehr | Summary: To quantify the cerebellum’s contributions to control of the tongue, we trained head-fixed marmosets to make dexterous movements, harvesting food from […]


Continue.. Control of tongue movements by the Purkinje cells of the cerebellum

Hydrophilic/ Omniphobic droplet arrays for high-throughput and quantitative enzymology

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Kavli Affiliate: Michael Miller | Authors: Byungjin Lee, Fanny Sunden, Michael Miller, Bumshik Pak, Anke Krebber, Stefan Lutz and Polly M Fordyce | Summary: Engineered enzymes with enhanced or novel functions are specific catalysts with wide-ranging applications in industry and medicine. Here, we introduce Droplet Array Microfluidic Enzyme Kinetics (DA-MEK), a high-throughput enzyme screening platform […]


Continue.. Hydrophilic/ Omniphobic droplet arrays for high-throughput and quantitative enzymology

Stimulation of locus coeruleus inputs to the frontal cortex in mice induces cell type-specific expression of the Apoe gene

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Kavli Affiliate: Keri Martinowich | Authors: Genevieve E Craig, Lizbeth Ramos, Samuel R Essig, Nicholas J Eagles, Andrew E Jaffe, Keri Martinowich and Henry L Hallock | Summary: Deficits in attention are common across a range of neuropsychiatric disorders. A multitude of brain regions, including the frontal cortex (FC) and locus coeruleus (LC), have been […]


Continue.. Stimulation of locus coeruleus inputs to the frontal cortex in mice induces cell type-specific expression of the Apoe gene

Decoding contextual influences on auditory perception from primary auditory cortex

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Kavli Affiliate: Mounya Elhilali | Authors: Bernhard Englitz, Sahar Akram, Mounya Elhilali and Shihab Shamma | Summary: SPerception can be highly dependent on stimulus context, but whether and how sensory areas encode the context remains uncertain. We used an ambiguous auditory stimulus – a tritone pair – to investigate the neural activity associated with a […]


Continue.. Decoding contextual influences on auditory perception from primary auditory cortex

Mammalian D-Cysteine controls insulin secretion in the pancreas

Posted by dbos Hopkins

Kavli Affiliate: Solomon Snyder | Authors: Robin Roychaudhuri, Timothy West, Soumyaroop Bhattacharya, Harry Saavedra, Lauren Albacarys, Moataz M Gadalla, Leon Mario Amzel, Peixin Yang and Solomon H. Snyder | Summary: D-amino acids are being recognized in mammals as important molecules with function. This is a first identification of endogenous D-cysteine in mammalian pancreas. D-cysteine is […]


Continue.. Mammalian D-Cysteine controls insulin secretion in the pancreas