Kavli Affiliate: Dwight Bergles | Authors: Saman Hussain, Miloslav Sedlacek, Runjia Cui, Wendy Zhang-Hooks, Dwight E Bergles, Jung-Bum Shin, Katie Kindt and Bechara Kachar | Summary: The hair bundle of auditory and vestibular hair cells converts mechanical stimuli into electrical signals through mechanoelectrical transduction (MET). The MET apparatus is built around a tip link that […]
Kavli Affiliate: Keri Martinowich | Authors: Nicholas J. Eagles, Svitlana V. Bach, Madhavi Tippani, Prashanti Ravichandran, Yufeng Du, Ryan A. Miller, Thomas Hyde, Stephanie C. Page, Keri Martinowich and Leonardo Collado-Torres | Summary: Background Visium is a widely-used spatially-resolved transcriptomics assay available from 10x Genomics. Standard Visium capture areas (6.5mm by 6.5mm) limit the survey […]
Kavli Affiliate: Jin Kang | Authors: Yingying Zhang, Alden K Leung, Jin Joo Kang, Yu Sun, Guanxi Wu, Le Li, Jiayang Sun, Lily Cheng, Tian Qiu, Junke Zhang, Shayne Wierbowski, Shagun Gupta, James Booth and Haiyuan Yu | Summary: A major goal of cancer biology is to understand the mechanisms underlying tumorigenesis driven by somatically […]
Kavli Affiliate: Michael Miller | Authors: Hannah Mummey, Weston Elison, Katha Korgaonkar, Ruth Elgamel, Parul Kudtarkar, Emily Griffin, Paola Benaglio, Michael Miller, Alokkumar Jha, Jocelyn E Manning Fox, Mark Mccarthy, Sebastian Preissl, Anna L Gloyn, Patrick E Macdonald and Kyle J Gaulton | Summary: Physiological variability in pancreatic cell type gene regulation and the impact […]
Kavli Affiliate: Denis Wirtz | Authors: Ashley L Kiemen, Cristina Almagro Perez, Valentina Matos Romero, André Forjaz, Alicia M Braxton, Lucie Dequiedt, Jeeun Parksong, Courtney D Cannon, Xuan Yuan, Sarah M Shin, Jaanvi Mahesh Babu, Elizabeth D Thompson, Toby C Cornish, Won Jin Ho, Laura D Wood, PeiHsun Wu, Arrate Munoz-Barrutia, Ralph H Hruban and […]
Kavli Affiliate: Keri Martinowich | Authors: Alexa F Iannitelli, Leslie Hassanein, Bernard Mulvey, Harris Blankenship, L Cameron Liles, Amanda L Sharpe, Jean-Francois Pare, Arielle Segal, Steven A Sloan, Keri Martinowich, Katharine E McCann, Joseph D Dougherty, Yoland Smith, Michael J Beckstead and David Weinshenker | Summary: The locus coeruleus (LC), the major source of norepinephrine […]
Kavli Affiliate: Daeyeol Lee | Authors: Min Song, Eun Ju Shin, Hyojung Seo, Alireza Soltani, Nicholas A Steinmetz, Daeyeol Lee, Min Whan Jung and Se-Bum Paik | Summary: Many anatomical and physiological features of cortical circuits, ranging from the biophysical properties of synapses to the connectivity patterns among different neuron types, exhibit consistent variation along […]
Kavli Affiliate: Reza Shadmehr | Authors: Paul Hage, Mohammad Amin Fakharian, Alden M. Shoup, Jay S Pi, Ehsan Sedaghat-Nejad, Simon P Orozco, In Kyu Jang, Vivian Looi, Toren Arginteanu and Reza Shadmehr | Summary: To quantify the cerebellum’s contributions to control of the tongue, we trained head-fixed marmosets to make dexterous movements, harvesting food from […]
Kavli Affiliate: Michael Miller | Authors: Byungjin Lee, Fanny Sunden, Michael Miller, Bumshik Pak, Anke Krebber, Stefan Lutz and Polly M Fordyce | Summary: Engineered enzymes with enhanced or novel functions are specific catalysts with wide-ranging applications in industry and medicine. Here, we introduce Droplet Array Microfluidic Enzyme Kinetics (DA-MEK), a high-throughput enzyme screening platform […]
Kavli Affiliate: Keri Martinowich | Authors: Genevieve E Craig, Lizbeth Ramos, Samuel R Essig, Nicholas J Eagles, Andrew E Jaffe, Keri Martinowich and Henry L Hallock | Summary: Deficits in attention are common across a range of neuropsychiatric disorders. A multitude of brain regions, including the frontal cortex (FC) and locus coeruleus (LC), have been […]