Kavli Affiliate: Jeremy Nathans | Authors: Philip V Seegren, Amir Rattner, Philip M Smallwood and Jeremy Nathans | Summary: Neonatal bacterial meningitis is a leading cause of infant morbidity and mortality, yet the molecular and cellular basis of the leptomeningeal response to infection remains poorly defined. Here, we study a mouse model of neonatal E. […]

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Keri Martinowich | Authors: Helena L Crowell, Yixing Dong, Ilaria Billato, Peiying Cai, Martin Emons, Samuel Gunz, Boyi Guo, Mengbo Li, Alexandru Mahmoud, Artür Manukyan, Hervé Pagès, Pratibha Panwar, Shreya Rao, Callum J Sargeant, Lori Shepherd Kern, Marcel Ramos, Jieran […]

  Kavli Affiliate: Seth Blackshaw | Authors: Jianming Shao, Xuan Bao, Ismail Yaman, Ye Zheng, Jun Wang, Jin Li, Tingting Yang, Jinjing Jian, Jean Li, Seth Blackshaw, Kapil Bharti, Margo Clarke, Dwight E. Stambolian, Ching-Hwa Sung, Jie J. Zheng, Davide Ortolan, Sarah X. Zhang, Ruchi Sharma, Richard H. Scheuermann, Ajith V. Pankajam, Ahmed H. Ghobashi, […]

Kavli Affiliate: Jin Kang | Authors: Oriol Fornes, Kyung Duk Koh, Rebecca M Marton, Jiapei Chen, Kevin A Marroquin, Gyeong Jin Kang, Avantika Lal, Sören Müller, Gokcen Eraslan, Eliah R Shamir, Pratiksha I Thakore, Heinrich Jasper and David Garfield | Summary: Effective recombinant adeno-associated virus gene therapies require promoters that are compact and cell-type-specific. Ideally, […]

Kavli Affiliate: Martin Lindquist | Authors: Yanxi Liu, Richard E. Harris, Daniel Clauw, Emine Bayman, Andrew Leroux and Martin A. Lindquist | Summary: Chronic pain is a widespread public health issue that imposes substantial health, emotional, and economic burdens on individuals and communities. Because pain is subjective and lacks objective biomarkers, it is typically measured […]

Kavli Affiliate: Vikram Chib | Authors: Aram Kim and Vikram S. Chib | Summary: Decisions to exert effort for reward are often conceptualized as reflecting a trade-off between anticipated benefits and effort costs. However, economic theories propose that valuation is reference-dependent, such that behavior is shaped relative to expected outcomes rather than absolute reward magnitude. […]

Kavli Affiliate: Justus M Kebschull | Authors: Angela Y Fan, Jack T Scott, Noah M Kuehn, Maryam Majeed, Sabrina Y Cheng, Huihui Qi, Mathew T Summers, John Hover, Tye Johnson, Ben Ouellette, Alana A Oyama, Diana Ravens, Huiqing Zhan, Justus M Kebschull, James A Bourne and Xiaoyin Chen | Summary: Across mammals, brain regions can […]

Kavli Affiliate: Alex Kolodkin | Authors: Natalie R Hamilton, Victoria N Neckles, Timour Al-Khindi, Nitya Donthi, Shun Mizutori, Renata Fu, James K Kiraly, Bea C Winship, Alex L Kolodkin and Karina Chaudhari | Summary: The optokinetic reflex (OKR) is an evolutionarily conserved reflexive behavior that ensures image stabilization on the retina during global motion. It […]

Kavli Affiliate: Adam S. Charles and Patricia Janak | Authors: Aamna Lawrence, Eva Yezerets, Patricia H Janak and Adam Charles | Summary: Neural systems exhibit multiple firing states that reflect an organism’s internal state and modulate the relationship between external environmental stimuli and behavior. Several studies have inferred these latent states by supplementing the traditional […]

Kavli Affiliate: Vikram Chib | Authors: Naser Al-Fawakhiri, Vikram S. Chib and Samuel D. McDougle | Summary: Multiple learning signals can shape motor output, including reward and punishment (via value-based reinforcement learning) and sensorimotor error (via motor adaptation). However, it is unclear if action values, learned via reinforcement learning, interact with error-based motor learning. Here, […]