Multiscale spatial transcriptomics resolves the cellular and molecular architecture of the human amygdala

Kavli Affiliate: Keri Martinowich | Authors: Michael S. Totty, Svitlana V. Bach, Madeline R. Valentine, Madhavi Tippani, Sarah E. Maguire, Ishbel Del Rosario Alvia, Ryan A. Miller, Joel E. Kleinman, Kristen R. Maynard, Stephanie Cerceo Page, Thomas M. Hyde, Stephanie C. Hicks and Keri Martinowich | Summary: The amygdala is a central hub for emotional […]


Continue.. Multiscale spatial transcriptomics resolves the cellular and molecular architecture of the human amygdala

Criterion-selective neurons in the human medial frontal cortex track decision thresholds during memory-based decision making

Kavli Affiliate: Michael Miller | Authors: Evan Layher, Ivan Skelin, Chrystal M Reed, Jeffrey M Chung, Lisa M Bateman, Taufik A Valiante, Adam N Mamelak, Michael B Miller and Ueli Rutishauser | Summary: The decision criterion is foundational to theories of decision-making, yet little is known about its neural underpinnings. In memory-based decision making, the […]


Continue.. Criterion-selective neurons in the human medial frontal cortex track decision thresholds during memory-based decision making

A Beta-Binomial Model for Estimating Zero- or One-inflated Pain Trajectories

Kavli Affiliate: Martin Lindquist | Authors: Yanxi Liu, Richard E. Harris, Daniel Clauw, Emine Bayman, Andrew Leroux and Martin A. Lindquist | Summary: Chronic pain is a widespread public health issue that imposes substantial health, emotional, and economic burdens on individuals and communities. Because pain is subjective and lacks objective biomarkers, it is typically measured […]


Continue.. A Beta-Binomial Model for Estimating Zero- or One-inflated Pain Trajectories

Working memory retention by medial entorhinal cortex low-dimensional neural dynamics

Kavli Affiliate: Jill Leutgeb | Authors: Li Yuan, Jiarui Wang, Xiaohe Li, Wenxi Li, Johnatan Aljadeff, Jill K Leutgeb and Stefan Leutgeb | Summary: The ability to retain information over tens of seconds is essential for carrying out many routine tasks. Recurrently connected circuits are thought to support memory over these timescales, yet how they […]


Continue.. Working memory retention by medial entorhinal cortex low-dimensional neural dynamics

Spatiotemporal Dissociation of Human Amygdala Response to Negative Affect

Kavli Affiliate: Martin Lindquist | Authors: Ke Bo, Martin Lindquist, Peter J Gianaros and Tor Wager | Summary: The amygdala is central to negative affect and a primary target of top-down regulation, yet its temporal dynamics remain poorly characterized. Most fMRI studies model stimulus-evoked amygdala activity with a canonical hemodynamic response function and collapse across […]


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Bile acid signaling as a therapeutically tractable pathway linking early caregiving adversity to social behavior

Kavli Affiliate: Maya Opendak | Authors: Cesar Medina, Pragney Deme, Vishal Win, Isabellah Nikitah, Isaac S McKie, Mingyuan Song, Maria Raudales, Elaina Regier, Emily Amsden, Pranali Bendale, Norman Haughey and Maya Opendak | Summary: Adverse early caregiving produces lasting changes in social behavior and increases vulnerability to psychiatric illness, yet the biological pathways through which […]


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GIAnT: a Glutamate Imaging Analysis Toolbox

Kavli Affiliate: Adam S. Charles | Authors: Michael E. Xie, Johannes Friedrich, Elizabeth Wirsching, Caleb Jones Shibu, Maedeh Seyedolmohadesin, Naveen Ouellette, Tim Wang, Karel Svoboda, Adam S Charles and Kaspar Podgorski | Summary: Recent advances in fluorescent indicators and optical microscopy now enable in vivo synaptic imaging of glutamate, which transmits the majority of signals between neurons […]


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Bats decouple sonar gaze from steering to resolve sensory conflict

Kavli Affiliate: Cynthia F. Moss | Authors: Nikita M Finger, Shivam S Chitnis, Grace Capshaw, Alara Kaplanoglu, Anand Krishnan and Cynthia F Moss | Summary: When sensory modalities yield conflicting information, animals must rapidly reassess stimuli to select their actions. We induced auditory–visual conflict in free-flying echolocating Egyptian fruit bats, by fitting animals with prisms […]


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SLAy-ing oversplitting errors in high-density electrophysiology spike sorting

  Kavli Affiliate: Adam S. Charles and Kathleen Cullen | Authors: Sai Koukuntla, Tate DeWeese, Alexandra Cheng, Robyn Mildren, Aamna Lawrence, Austin R Graves, Kathleen E Cullen, Jennifer Colonell, Timothy D Harris and Adam S Charles | Summary: The growing channel count of silicon probes has substantially increased the number of neurons recorded in electrophysiology […]


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Behavioural and neural mechanisms for stochastic choices in mixed strategy games

  Kavli Affiliate: Daeyeol Lee | Authors: Joanna Aloor, Timothy PH Sit, Oliver M Gauld, Joseph Warren, Matthew Mower, Daeyeol Lee and Chunyu A. Duan | Summary: Adaptive behaviour usually requires exploiting regularities in the environment, but in competitive settings the opposite can be true: predictable choice patterns can be exploited by others, making unpredictability […]


Continue.. Behavioural and neural mechanisms for stochastic choices in mixed strategy games