Oxysterol-liver X receptor signaling mediates CYFIP1 regulation of cortical neurogenesis

Kavli Affiliate: David Linden | Authors: Daniel C de la Fuente, Claudia Tamburini, Emily Stonelake, William J Griffiths, Jeremy Hall, Michael J Owen, David E. J. Linden, Andrew Pocklington, Yuqin Wang and Meng Li | Summary: Dysregulation in neural progenitor proliferation and neuronal differentiation has been increasingly recognised as a common pathology in neural cells […]


Continue.. Oxysterol-liver X receptor signaling mediates CYFIP1 regulation of cortical neurogenesis

Drebrin Regulates Collateral Axon Branching in Cortical Layer II/III Somatosensory Neurons

Kavli Affiliate: Alex Kolodkin | Authors: Joelle M Dorskind, Sriram Sudarsanam, Randal A Hand, Jakub Ziak, Maame Amoah-Dankwah, Luis Guzman-Clavel, John Lee Soto-Vargas and Alex L Kolodkin | Summary: Proper cortical lamination is essential for cognition, learning, and memory. Within the somatosensory cortex, pyramidal excitatory neurons elaborate axon collateral branches in a laminar-specific manner that […]


Continue.. Drebrin Regulates Collateral Axon Branching in Cortical Layer II/III Somatosensory Neurons

Measuring stimulus-related redundant and synergistic functional connectivity with single cell resolution in auditory cortex

Kavli Affiliate: Patrick Kanold | Authors: Loren Koçillari, Marco Celotto, Nikolas A. Francis, Shoutik Mukherjee, Behtash Babadi, Patrick O. Kanold and Stefano Panzeri | Summary: Measures of functional connectivity have played a central role in advancing our understanding of how information is communicated within the brain. Traditionally, these studies have focused on identifying redundant functional […]


Continue.. Measuring stimulus-related redundant and synergistic functional connectivity with single cell resolution in auditory cortex

Spatially clustered neurons encode vocalization categories in the bat midbrain

Kavli Affiliate: Kishore V. Kuchibhotla, Cynthia F. Moss | Authors: Jennifer Lawlor, Melville Wohlgemuth, Cynthia F Moss and Kishore V Kuchibhotla | Summary: Rapid categorization of vocalizations enables adaptive behavior across species. While categorical perception is thought to arise in the neocortex, humans and other animals could benefit from functional organization of ethologically-relevant sounds at […]


Continue.. Spatially clustered neurons encode vocalization categories in the bat midbrain

Lysinoalanine crosslinking is a conserved post-translational modification in the spirochete flagellar hook

Kavli Affiliate: Michael Miller | Authors: Michael J. Lynch, Maithili Deshpande, Kurni Kyrniyati, Kai Zhang, Milinda James, Michael Miller, Sheng Zhang, Felipe J. Passalia, Elsio A. Wunder, Jr., Nyles W. Charon, Chunhao Li and Brian R Crane | Summary: Spirochete bacteria cause Lyme disease, leptospirosis, syphilis and several other human illnesses. Unlike other bacteria, spirochete […]


Continue.. Lysinoalanine crosslinking is a conserved post-translational modification in the spirochete flagellar hook

Precision-engineered biomimetics: the human fallopian tube

Kavli Affiliate: Denis Wirtz | Authors: Ashleigh J Crawford, André Forjaz, Isha Bhorkar, Triya Roy, David Schell, Vasco Queiroga, Kehan Ren, Donald Kramer, Joanna Bons, Wilson Huang, Gabriella C Russo, Meng-Horng Lee, Birgit Schilling, Pei-Hsun Wu, Ie-Ming Shih, Tian-Li Wang, Ashley Kiemen and Denis Wirtz | Summary: The fallopian tube has an essential role in […]


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Conjunctive vector coding and place coding in hippocampus share a common directional signal

Kavli Affiliate: James Knierim | Authors: Yue-Qing Zhou, Vyash Puliyadi, Xiaojing Chen, Joonhee Leo Lee, Lan-Yuan Zhang and James J Knierim | Summary: Vector coding is becoming increasingly understood as a major mechanism by which neural systems represent an animal’s location in both a global reference frame and a local, item-based reference frame. Landmark vector […]


Continue.. Conjunctive vector coding and place coding in hippocampus share a common directional signal

An Open-Source Tool for Automated Human-Level Circling Behavior Detection

Kavli Affiliate: Kathleen Cullen | Authors: Oliver R Stanley, Ananya Swaminathan, Elias Wojahn, Zubair M Ahmed and Kathleen E Cullen | Summary: Quantifying behavior and relating it to underlying biological states is of paramount importance in many life science fields. Although barriers to recording postural data have been reduced by progress in deep-learning-based computer vision […]


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Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

Kavli Affiliate: Kathleen Cullen | Authors: Arnaud P. J. Giese, Wei-Hsiang Weng, Katie S Kindt, Vanessa H. H. Chang, Jonathan S Montgomery, Evan M. Ratzan, Alisha J. Beirl, Roberto Aponte Rivera, Jeffrey M. Lotthammer, Sanket Walujkar, Mark P. Foster, Omid A. Zobeiri, Jeffrey R. Holt, Saima Riazuddin, Kathleen E. Cullen, Marcos Sotomayor and Zubair M […]


Continue.. Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

Mouse models of SYNGAP1-related intellectual disability

Kavli Affiliate: Hey-Kyoung Lee, Richard Huganir | Authors: Yoichi Araki, Elizabeth E. Gerber, Kacey E. Rajkovich, Ingie Hong, Richard C. Johnson, Hey-Kyoung Lee, Alfredo Kirkwood and Richard L. Huganir | Summary: SYNGAP1 is a Ras-GTPase activating protein highly enriched at excitatory synapses in the brain. De novo loss-of-function mutations in SYNGAP1 are a major cause […]


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