The Cousa objective: a long working distance air objective for multiphoton imaging in vivo

Kavli Affiliate: Michael Higley, Alipasha Vaziri, Kristina Nielsen | Authors: Che-Hang Yu, Yiyi Yu, Liam M. Adsit, Jeremy T. Chang, Jad Barchini, Andrew H. Moberly, Hadas Benisty, Jinkyung Kim, Brent K Young, Kathleen Heng, Deano M. Farinella, Austin Leikvoll, Rishaab Pavan, Rachel Vistein, Brandon R. Nanfito, David G. C. Hildebrand, Santiago Otero-Coronel, Alipasha Vaziri, Jeffery […]


Continue.. The Cousa objective: a long working distance air objective for multiphoton imaging in vivo

Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells

Kavli Affiliate: Seth Blackshaw | Authors: Cheng Qian, Ying Xin, Cheng Qi, Hui Wang, Bryan C. Dong, Donald Zack, Seth Blackshaw, Samer Hattar, Feng-Quan Zhou and Jiang Qian | Summary: The progressive death of mature neurons often results in neurodegenerative diseases. While the previous studies have mostly focused on identifying intrinsic mechanisms controlling neuronal survival, […]


Continue.. Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells

Improved Protocol for Reproducible Human Cortical Organoids Reveals Early Alterations in Metabolism with MAPT Mutations

Kavli Affiliate: Michael Miller | Authors: Taylor Bertucci, Kathryn R Bowles, Steven Lotz, Le Qi, Katherine Stevens, Susan K Goderie, Susan Borden, Laura Oja, Keith Lane, Ryan Lotz, Hailey Lotz, Rebecca Chowdhury, Shona Joy, Brigitte L Arduini, David C Butler, Michael Miller, Heide Baron, Carl Alexander Sandhof, M. Catarina Silva, Stephen J Haggarty, Celeste M […]


Continue.. Improved Protocol for Reproducible Human Cortical Organoids Reveals Early Alterations in Metabolism with MAPT Mutations

Revealing abrupt transitions from goal-directed to habitual behavior

Kavli Affiliate: Kishore V. Kuchibhotla, Adam S. Charles | Authors: Sharlen Moore, Zyan Wang, Ziyi Zhu, Ruolan Sun, Angel Lee, Adam Charles and Kishore V Kuchibhotla | Summary: A fundamental tenet of animal behavior is that decision-making involves multiple ‘controllers.’ Initially, behavior is goal-directed, driven by desired outcomes, shifting later to habitual control, where cues […]


Continue.. Revealing abrupt transitions from goal-directed to habitual behavior

TrkB-dependent regulation of molecular signaling across septal cell types

Kavli Affiliate: Keri Martinowich | Authors: Lionel A Rodriguez, Matt N Tran, Renee Garcia-Flores, Elizabeth A Pattie, Sun-Hong Kim, Joo Heon Shin, Yong Kyu Lee, Heena R Divecha, Carly Montoya, Andrew E Jaffe, Leonardo Collado Torres, Stephanie Cerceo Page and Keri Martinowich | Summary: The lateral septum (LS), a GABAergic structure located in the basal […]


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Encoding and context-dependent control of reward consumption within the central nucleus of the amygdala

Kavli Affiliate: Patricia Janak | Authors: Kurt M. Fraser, Tabitha H. Kim, Matilde Castro, Céline Drieu, Yasmin Padovan-Hernandez, Bridget Chen, Fiona Pat, David J. Ottenheimer and Patricia H. Janak | Summary: The ability to evaluate and select a preferred option among a variety of available offers is an essential aspect of goal-directed behavior. Dysregulation of […]


Continue.. Encoding and context-dependent control of reward consumption within the central nucleus of the amygdala

Oxysterol-liver X receptor signaling mediates CYFIP1 regulation of cortical neurogenesis

Kavli Affiliate: David Linden | Authors: Daniel C de la Fuente, Claudia Tamburini, Emily Stonelake, William J Griffiths, Jeremy Hall, Michael J Owen, David E. J. Linden, Andrew Pocklington, Yuqin Wang and Meng Li | Summary: Dysregulation in neural progenitor proliferation and neuronal differentiation has been increasingly recognised as a common pathology in neural cells […]


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Drebrin Regulates Collateral Axon Branching in Cortical Layer II/III Somatosensory Neurons

Kavli Affiliate: Alex Kolodkin | Authors: Joelle M Dorskind, Sriram Sudarsanam, Randal A Hand, Jakub Ziak, Maame Amoah-Dankwah, Luis Guzman-Clavel, John Lee Soto-Vargas and Alex L Kolodkin | Summary: Proper cortical lamination is essential for cognition, learning, and memory. Within the somatosensory cortex, pyramidal excitatory neurons elaborate axon collateral branches in a laminar-specific manner that […]


Continue.. Drebrin Regulates Collateral Axon Branching in Cortical Layer II/III Somatosensory Neurons

Measuring stimulus-related redundant and synergistic functional connectivity with single cell resolution in auditory cortex

Kavli Affiliate: Patrick Kanold | Authors: Loren Koçillari, Marco Celotto, Nikolas A. Francis, Shoutik Mukherjee, Behtash Babadi, Patrick O. Kanold and Stefano Panzeri | Summary: Measures of functional connectivity have played a central role in advancing our understanding of how information is communicated within the brain. Traditionally, these studies have focused on identifying redundant functional […]


Continue.. Measuring stimulus-related redundant and synergistic functional connectivity with single cell resolution in auditory cortex

Spatially clustered neurons encode vocalization categories in the bat midbrain

Kavli Affiliate: Kishore V. Kuchibhotla, Cynthia F. Moss | Authors: Jennifer Lawlor, Melville Wohlgemuth, Cynthia F Moss and Kishore V Kuchibhotla | Summary: Rapid categorization of vocalizations enables adaptive behavior across species. While categorical perception is thought to arise in the neocortex, humans and other animals could benefit from functional organization of ethologically-relevant sounds at […]


Continue.. Spatially clustered neurons encode vocalization categories in the bat midbrain