Exploring endothelial cell environments across organs in spatially resolved omics data

Kavli Affiliate: Jean Fan | Authors: Yashvardhan Jain, Jodie Jepson, Roy Chen, Elizabeth Maier, Bruce W. Herr II, Aleix Puig-Barbe, Ellen M. Quardokus, Danial Qaurooni, Clarence Yapp, Samuel L. Ewing, Archibald Enninful, Negin Farzad, Andreas Bueckle, Quinn T. Easter, Bruno Matuck, Chenchen Zhu, Emma Marie Monte, Jeffrey M. Purkerson, Matthew Jehrio, Ravi S. Misra, Rong […]


Continue.. Exploring endothelial cell environments across organs in spatially resolved omics data

Toward navigating emotional states using real-time representational similarity analysis fMRI neurofeedback – a feasibility study

Kavli Affiliate: David Linden | Authors: Xuelei Wang, Assunta Ciarlo, Michael Luehrs, Alexander Atanasyan, David Böken, Jürgen Roßmann, Michael Schluse, Maren Jäger, Marisa Nordt, Fengyu Cong, Klaus Mathiak, David Linden, Rainer Goebel, David MA Mehler and Jana Zweerings | Summary: Real-time functional magnetic resonance imaging neurofeedback (rt-fMRI-NF) is a promising non-invasive brain-computer-interface (BCI) technique for […]


Continue.. Toward navigating emotional states using real-time representational similarity analysis fMRI neurofeedback – a feasibility study

JACUZI-SD: An automated, high-throughput, minimally stressful approach to sleep depriving larval zebrafish.

Kavli Affiliate: Seth Blackshaw | Authors: Leah J Elias, Harrison Khoo, Francois Kroll, Caroline Zhang, Soojung C Hur, Jason Rihel and Seth Blackshaw | Summary: While sleep deprivation broadly disrupts health and well-being, the neural and molecular mechanisms that signal increased sleep pressure remain poorly understood. A key obstacle to progress is the fact that […]


Continue.. JACUZI-SD: An automated, high-throughput, minimally stressful approach to sleep depriving larval zebrafish.

3D multi-omic mapping of whole nondiseased human fallopian tubes at cellular resolution reveals a large incidence of ovarian cancer precursors

Kavli Affiliate: Denis Wirtz | Authors: André Forjaz, Vasco Queiroga, Yajuan Li, Alfredo Hernandez, Ashleigh Crawford, Xiaoyu Qin, Mei Zhong, Margarita Tsapatsis, Saurabh Joshi, Donald Kramer, Oliver Nizet, Habin Bea, Yuhan Li, Shuo Qin, Robert O Flynn, Mingder Yang, Britanny Pratt, Fan Wu, Paul Gensbigler, Max Blecher, Pei-Hsun Wu, Luciane Tsukamoto Kagohara, Ie Ming Shih, […]


Continue.. 3D multi-omic mapping of whole nondiseased human fallopian tubes at cellular resolution reveals a large incidence of ovarian cancer precursors

CNS-Tau Specific Antibodies Illuminate Disease Signatures Across Tauopathies

Kavli Affiliate: Michael Miller | Authors: Lei Liu, Yin Zheng, Luke Slominski, Qimin Quan, Adriana Saba, Jean-Pierre Bellier, Han-Bin Yoo, Andrea Roman, Elizabeth L Hennessey, Samadhi Wijethunga, Elif Lara Okyay, Michael B Miller, Hyun-Sik Yang, Dennis J Selkoe and Jasmeer Chhatwal | Summary: Background Alternative splicing of the MAPT gene produces distinct tau isoforms in […]


Continue.. CNS-Tau Specific Antibodies Illuminate Disease Signatures Across Tauopathies

Altered NPTX2 dynamics associated with impaired cognitive aging

Kavli Affiliate: Michela Gallagher | Authors: Rebecca P. Haberman, Ana Delgado, Meifang Xiao, Ming Teng Koh, Ashley A Becker, Shiyu Ji, Paul F Worley, Michela Gallagher and Audrey E. Branch | Summary: Changes in synaptic integrity and neural activity homeostasis are hallmarks of brain aging and are closely tied to cognitive outcomes. Yet, defining their […]


Continue.. Altered NPTX2 dynamics associated with impaired cognitive aging

Separating the control of moving and holding still in post-stroke arm paresis

Kavli Affiliate: Reza Shadmehr | Authors: Alkis M. Hadjiosif, Kahori Kita, Scott T. Albert, Robert A. Scheidt, Reza Shadmehr and John W. Krakauer | Summary: Moving and holding still have been posited to be under separate control regimes for both eye and arm movements. The paretic arm after stroke is notable for abnormalities both at […]


Continue.. Separating the control of moving and holding still in post-stroke arm paresis

Single-cell long-read sequencing of the experience-induced transcriptome

Kavli Affiliate: Richard Huganir | Authors: Sheridan Cavalier, Paul W Hook, Richard L. Huganir and Winston Timp | Summary: Neural activity drives transcriptional events that are critical for learning. Activity-induced transcript isoform expression and alternative splicing are cell-type specific events typically obscured by sequencing approaches that restrict read length. We combined single-cell transcriptomics with Nanopore […]


Continue.. Single-cell long-read sequencing of the experience-induced transcriptome

Comparative single-cell multiomic analysis reveals evolutionarily conserved and species-specific cellular mechanisms mediating natural retinal aging.

Kavli Affiliate: Seth Blackshaw | Authors: Pin Lyu, Isabella Palazzo, yang jin, Leah Campbell, Clayton Santiago, Rogger Carmen-Orzoco, Thanh Hoang, Jared Tangeman, Alexander Park, Shawn Yang, Jianming Shao, Rui Chen, David Hyde, Jiang Qian and Seth Blackshaw | Summary: Biological age is a major risk factor in the development of common degenerative retinal diseases such […]


Continue.. Comparative single-cell multiomic analysis reveals evolutionarily conserved and species-specific cellular mechanisms mediating natural retinal aging.

Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test

Kavli Affiliate: Keri Martinowich | Authors: Jorge Alberto Miranda-Barrientos, Suhaas Adiraju, Jason J Rehg, Michael S Totty, Henry Hallock, Ye Li, Greggory Carr and Keri Martinowich | Summary: Sustained attention, the ability to focus on a stimulus or task over extended periods, is crucial for higher level cognition, and is impaired across multiple neuropsychiatric and […]


Continue.. Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test