Kavli Affiliate: Michael Miller | Authors: Alessandra Castaldi, Ji Sun Chin, Benjamin Ma, Max W Chang, Kayla Samimi, Alexa Allen, William Pinon-Rose, Jonathan Castillo, Parham Zamani, Mindy Xie, Nataly Arias, Kayvon Solaimanpour, Yixin Liu, Hua Shen, Brian T Scott, Masafumi Horie, Per Flodby, Ana Kasirer-Friede, Kelsey Dang, Justin Buchanan, Ryan Lancione, Michael Miller, Qiang Yang, […]

Kavli Affiliate: Denis Wirtz | Authors: Florin Selaru, Jude Phillip, Denis Wirtz and Pei-Hsun Wu | Summary: Advancements in computational approaches have enabled robust utilization of histological tissue data. A crucial step in the development of computational tools for the objective and quantitative analysis of tissue sections has been color deconvolution. Color deconvolution functions by […]

Kavli Affiliate: Jin Kang | Authors: Shiying Huang, Yeun Ju Kim, Xiaofu Cao, Timothy W Bumpus, Mira Sohn, Matthew Tyler Menold, Ryan S Dale, Jin Joo Kang, Saori Uematsu, Shagun Gupta, Shu-Bing Qian, Haiyuan Yu, Tamas Balla and Jeremy M Baskin | Summary: Cells tightly control the homeostatic levels and subcellular localizations of membrane phospholipids […]

Kavli Affiliate: Marshall Hussain Shuler | Authors: Elissa Sutlief, Shichen Zhang, Kate Forsberg, Rie Kaneko and Marshall G Hussain Shuler | Summary: Activities with diminishing returns pose a unique computational problem for the brain, requiring a combination of outcome evaluation and temporal tracking. Deciding the right time to stop one pursuit and move to alternatives […]

Kavli Affiliate: Martin Lindquist | Authors: Patrick Sadil and Martin A. Lindquist | Summary: Task-based functional magnetic resonance imaging (fMRI) is a powerful tool for studying brain function. However, the reliability and viability of small-sample studies remain a concern. While it is well understood that larger samples are preferable, researchers often need to interpret findings […]

Kavli Affiliate: Denis Wirtz | Authors: Praful R Nair, Eban Hanna, Saurabh Joshi, Victoria Duarte Alvarado, Challice Bonifant and Denis Wirtz | Summary: Cellular immunotherapy has shown remarkable efficacy in hematological malignancies but remains limited by infiltration issues in solid tumors, leading to poor treatment efficacy. We have recently shown that mesothelin-targeting CAR T cells […]

Kavli Affiliate: Seth Blackshaw | Authors: Haley Appel, Rogger Carmen-Orozco, Clayton Santiago, Thanh Hoang and Seth Blackshaw | Summary: The RNA-binding protein Ptbp1 has been proposed as a master regulator of neuronal fate, repressing neurogenesis through its effects on alternative splicing and miRNA maturation. While prior studies using RNA interference suggested that Ptbp1 loss promotes […]

Kavli Affiliate: Seth Blackshaw | Authors: Jingliang Simon Zhang, Brian Guy, Clayton P Santiago, Caterina Tiozzo, Meghana Sreenath, Ya-Wen Chen, Seth Blackshaw and Robert J Johnston, Jr | Summary: Retinal ganglion cells (RGCs) are the projection neurons that transmit visual information from the retina to the brain. In many species, a substantial proportion of RGCs […]

Kavli Affiliate: Alexander Szalay | Authors: Tricia R Cottrell, Jeffrey S Roskes, Michael Fotheringham, Emily Cohen, Boyang Zhang, Logan L Engle, Daphne Wang, Elizabeth Will, Joel C Sunshine, Daniel Jimenez-Sanchez, Zhen Zheng, Justina X Caushi, Jiajia Zhang, Nina D’Amiano, Julie Stein-Deutsch, Sonali Uttam, Katie Pirie, Darah Vlaminck, Michelle Mataj, Alexa Fiorante, Nicole Espinosa, Teodora Popa, […]

Kavli Affiliate: Keri Martinowich | Authors: Prashanthi Ravichandran, Svitlana V. Bach, Robert A. Phillips III, Madeline R. Valentine, Nicholas J. Eagles, Yufeng Du, Ishbel Del Rosario, Ryan A. Miller, Heena R. Divecha, Madhavi Tippani, Kelsey D. Montgomery, Joel E. Kleinman, Shizhong Han, Stephanie Cerceo Page III, Thomas M. Hyde, Leonardo Collado Torres, Alexis Battle, Keri […]