Kavli Affiliate: David Linden | Authors: Friederike Ehrhart, Ana Silva, Therese Amelsvoort, Emma von Scheibler, Chris Evelo and David E.J. Linden | Summary: Schizophrenia genetics is complex, and the contribution of common and rare variants are not fully understood. Several specific copy number variations (CNVs) confer increased risk for schizophrenia, and the study of their […]
Kavli Affiliate: Loyal Goff | Authors: Jeanette Anna Irene Johnson, Ashley Tsang, Jacob T Mitchell, Emily F Davis-Marcisak, Thomas Sherman, Ted Liefeld, Melanie Loth, Loyal Goff, Jacquelyn Zimmerman, Ben Kinny-Köster, Elizabeth Jaffee, Pablo Tamayo, Jill Mesirov, Michael Reich, Elana J Fertig and Genevieve L Stein-O’Brien | Summary: Non-negative matrix factorization (NMF) is an unsupervised learning […]
Kavli Affiliate: Peter Searson | Authors: Zhaobin Guo, Nan Zhao, Tracy D. Chung, Anjan Singh, Ikshu Pandey, Linus Wang, Xinyue Gu, Aisha Ademola, Raleigh Miller Linville, Utpal Pal, J. Stephen Dumler and Peter C. Searson | Summary: Lyme disease is a tick-borne disease prevalent in North America, Europe, and Asia. Dissemination of vector-borne pathogens, such […]
Kavli Affiliate: Dwight Bergles | Authors: Calvin J Kersbergen, Travis A Babola, Jason Rock and Dwight E Bergles | Summary: Neurons that process sensory information exhibit bursts of electrical activity during development, providing early training to circuits that will later encode similar features of the external world. In the mammalian auditory system, this intrinsically generated […]
Kavli Affiliate: Loyal Goff | Authors: Shijie C. Zheng, Genevieve Stein-O’Brien, Leandros Boukas, Loyal A Goff and Kasper D Hansen | Summary: RNA velocity analysis of single cells promises to predict temporal dynamics from gene expression. Indeed, in many systems, it has been observed that RNA velocity produces a vector field that qualitatively reflects known […]
Kavli Affiliate: Menno Witter, Susumu Mori, Michael Miller | Authors: Kaitlin Stouffer, Claire Chen, Sue Kulason, Eileen Xu, Menno Witter, Can Ceritoglu, Marilyn Albert, Susumu Mori, Juan Troncoso, Daniel Jacob Tward and Michael I Miller | Summary: Previous research has emphasized the unique impact of Alzheimer’s Disease (AD) pathology on the medial temporal lobe (MTL), […]
Kavli Affiliate: Loyal Goff | Authors: Shijie C. Zheng, Genevieve Stein-O’Brien, Leandros Boukas, Loyal A Goff and Kasper D Hansen | Summary: RNA velocity analysis of single cells promises to predict temporal dynamics from gene expression. Indeed, in many systems, it has been observed that RNA velocity produces a vector field which qualitatively reflects known […]
Kavli Affiliate: Patrick Kanold | Authors: Binghan Xue, Joseph P-Y Kao and Patrick O Kanold | Summary: A common impairment in aging is age-related hearing loss (presbycusis), which manifests as impaired spectrotemporal processing. Aging is accompanied by alteration in normal inhibitory (GABA) neurotransmission and changes in excitatory (NMDA and AMPA) synapses in the auditory cortex […]
Kavli Affiliate: James Knierim | Authors: Manu S Madhav, Ravikrishnan P Jayakumar, Brian Y Li, Francesco Savelli, James J Knierim and Noah J Cowan | Summary: Understanding the interplay between sensory input, endogenous neural dynamics, and behavioral output is key toward understanding the principles of neural computation. Hippocampal place cells are an ideal system to […]
Kavli Affiliate: Solomon Snyder | Authors: Robin Roychaudhuri, Hasti Atashi and Solomon Snyder | Summary: The adult subventricular zone is one of the two neurogenic niches that continuously produce newborn neurons. Here we show that serine racemase (SR), an enzyme that catalyzes the racemization of L-serine to D-serine and vice versa, affects neurogenesis in the […]