Leveraging place field repetition to understand positional versus nonpositional inputs to hippocampal field CA1

Kavli Affiliate: James Knierim | Authors: William Hockeimer, Ruo-Yah Lai, Maanasa Natrajan, William Snider and James J. Knierim | Summary: The hippocampus is believed to encode episodic memory by binding information about the content of experience within a spatial framework encoding the location of that experience. Previous work implies a distinction between positional inputs to […]


Continue.. Leveraging place field repetition to understand positional versus nonpositional inputs to hippocampal field CA1

Physical resilience in the brain: The effect of white matter disease on brain networks in cognitively normal older adults

Kavli Affiliate: Michael Miller | Authors: Blake R Neyland, Samuel N Lockhart, Robert G Lyday, Laura D Baker, Elizabeth P Handing, Michael E Miller, Stephen B Kritchevsky, Paul J Laurienti and Christina E Hugenschmidt | Summary: BACKGROUND: Physical resilience with age is considered a key feature of healthy aging, but current understanding of the neural […]


Continue.. Physical resilience in the brain: The effect of white matter disease on brain networks in cognitively normal older adults

Bisected graph matching improves automated pairing of bilaterally homologous neurons from connectomes

Kavli Affiliate: Carey Priebe, Joshua Vogelstein | Authors: Benjamin D Pedigo, Michael Winding, Carey E Priebe and Joshua T Vogelstein | Summary: Graph matching algorithms attempt to find the best correspondence between the nodes of two networks. These techniques have previously been used to match individual neurons in nanoscale connectomes – in particular, to find […]


Continue.. Bisected graph matching improves automated pairing of bilaterally homologous neurons from connectomes

Guided construction of single cell reference for human and mouse lung

Kavli Affiliate: Jin Kang | Authors: Minzhe Guo, Michael P. Morley, Yixin Wu, Yina Du, Shuyang Zhao, Andrew Wagner, Michal Kouril, Kang Jin, Nathan Gaddis, Joseph A. Kitzmiller, Kathleen Stewart, Maria C. Basil, Susan M. Lin, Yun Ying, Apoorva Babu, Kathryn A. Wikenheiser-Brokamp, Kyu Shik Mun, Anjaparavanda P. Naren, Sara Lin, Geremy Clair, Joshua N. […]


Continue.. Guided construction of single cell reference for human and mouse lung

Serine Racemase is a Cysteine Racemase and Physiologic Down Regulator of Insulin Promoter Methylation

Kavli Affiliate: Solomon Snyder | Authors: Robin Roychaudhuri, Moataz M Gadalla, Lauren Albacarys, Timothy West, Harry Saavedra, Leon Mario Amzel and Solomon H. Snyder | Summary: Endogenous D-stereoisomers are being recognized as functionally important molecules in mammals. Here we report the first identification of endogenous D-cysteine in mammalian pancreas. Serine Racemase (SR) is the biosynthetic […]


Continue.. Serine Racemase is a Cysteine Racemase and Physiologic Down Regulator of Insulin Promoter Methylation

Transretinal migration of astrocytes and brain/spinal cord-like cells arising from transplanted human retinal organoids.

Kavli Affiliate: Seth Blackshaw | Authors: Ying Liu, Clayton Santiago, Akin Sogunro, Gregory K. Konar, Ming-Wen Hu, Minda M. McNally, Yuchen Lu, Zhuolin Li, Dzhalal Agakishiev, Sarah Hadyniak, Katarzyna Hussey, Tyler J. Creamer, Linda D. Orzolek, Derek Teng, Jiang Qian, Zheng Jiang, Robert J. Johnston, Jr., Seth Blackshaw and Mandeep S. Singh | Summary: Human […]


Continue.. Transretinal migration of astrocytes and brain/spinal cord-like cells arising from transplanted human retinal organoids.

Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood-brain barrier microvessels

Kavli Affiliate: Peter Searson | Authors: Raleigh M. Linville, Matthew B. Sklar, Gabrielle N. Grifno, Renee F. Nerenberg, Justin Zhou, Robert Ye, Jackson G. DeStefano, Zhaobin Guo, Ria Jha, John J. Jamieson, Nan Zhao and Peter C. Searson | Summary: The blood-brain barrier (BBB) plays a pivotal role in brain health and disease. In the […]


Continue.. Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood-brain barrier microvessels

The lateral habenula mediates the association of a conditioned stimulus with the absence of an appetitive unconditioned stimulus

Kavli Affiliate: Michela Gallagher | Authors: Dong-Hee Kim, In-Beom Jin, Nam-Heon Kim, Yong-Jae Jeon, Bo-Ryoung Choi, Michela Gallagher and Jung-Soo Han | Summary: The lateral habenula (LHb) has been implicated in conditioned inhibition. Here, the modulating effects of LHb activity on the association of a conditioned stimulus (CS) with the nonoccurrence of an unconditioned stimulus […]


Continue.. The lateral habenula mediates the association of a conditioned stimulus with the absence of an appetitive unconditioned stimulus

Rare CNVs and phenome-wide profiling: a tale of brain-structural divergence and phenotypical convergence

Kavli Affiliate: David Linden | Authors: J. Kopal, K. Kumar, K. Saltoun, C. Modenato, C. A. Moreau, S. Martin-Brevet, G. Huguet, M. Jean-Louis, C.O. Martin, Z. Saci, N. Younis, P. Tamer, E. Douard, A. M. Maillard, B. Rodriguez-Herreros, A. Pain, S. Richetin, 16p11.2 European Consortium, Simons Searchlight Consortium, L. Kushan, A. I. Silva, M. B. […]


Continue.. Rare CNVs and phenome-wide profiling: a tale of brain-structural divergence and phenotypical convergence

Projective LDDMM: Mapping Molecular Digital Pathology with Tissue MRI

Kavli Affiliate: Michael Miller, Menno Witter | Authors: Kaitlin Stouffer, Menno Witter, Daniel Tward and Michael Miller | Summary: Reconstructing dense 3D anatomical coordinates from 2D projective measurements has become a central problem in both mouse and human digital pathology. We describe a new family of diffeomorphic mapping technologies called Projective LDDMM which generate diffeomorphic […]


Continue.. Projective LDDMM: Mapping Molecular Digital Pathology with Tissue MRI