Kavli Affiliate: Michael Beer | Authors: Michael Beer, Ana Sofia F. Oliveira, Catherine L. Tooke, Philip Hinchliffe, Angie Tsz Yan Li, Balazs Balega, James Spencer and Adrian J Mulholland | Summary: β-Lactamases, which hydrolyse β-lactam antibiotics, are key determinants of antibiotic resistance. Predicting the sites and effects of distal mutations in enzymes is challenging. For […]
Kavli Affiliate: Jeremias Sulam | Authors: Zhenzhen Wang, Cesar A. Santa-Maria, Aleksander S. Popel and Jeremias Sulam | Summary: The tumor microenvironment is widely recognized for its central role in driving cancer progression and influencing prognostic outcomes. Despite extensive research efforts dedicated to characterizing this complex and heterogeneous environment, considerable challenges persist. In this study, […]
Kavli Affiliate: Keri Martinowich | Authors: Robert A Phillips III, Seyun Oh, Svitlana V Bach, Yufeng Du, Ryan A Miller, Joel E Kleinman, Thomas M Hyde, Stephanie C Hicks, Stephanie Cerceo Page and Keri Martinowich | Summary: The lateral septum (LS) is a midline, subcortical structure, which regulates social behaviors that are frequently impaired in […]
Kavli Affiliate: Denis Wirtz | Authors: Devon E Mason, Megan Goeckel, Sebastian L Vega, Pei-Hsun Wu, Dymonn Johnson, Su-Jin Heo, Denis Wirtz, Jason A Burdick, Levi Wood, Brain Y Chow, Amber N Stratman and Joel D Boerckel | Summary: Vascular morphogenesis requires persistent endothelial cell motility that is responsive to diverse and dynamic mechanical stimuli. […]
Kavli Affiliate: Brian Caffo Randal Burns Carey Priebe Joshua Vogelstein | Authors: Jaewon Chung, Ross Lawrence, Alexander Loftus, Gregory Kiar, Eric Bridgeford, Consortium for Reliability and Reproducibility, Vikram Chandrashekhar, Disa Mhembere, Sephira Ryman, Xi-Nian Zuo, Daniel Margulies, R. Cameron Craddock, Carey E. Priebe, Rex Jung, Vince D. Calhoun, Brian Caffo, Randal Burns, Michael P. Milham […]
Kavli Affiliate: Dwight Bergles | Authors: Vered Kellner, Patrick Parker, Xuelong Mi, Guoqiang Yu, Gesine Saher and Dwight E Bergles | Summary: Abstract Afferent neurons in developing sensory organs exhibit a prolonged period of burst firing prior to the onset of sensory experience. This intrinsically generated activity propagates from the periphery through central processing centers […]
Kavli Affiliate: Martin Lindquist | Authors: Martin Lindquist | Summary: Resting-state fMRI (rs-fMRI) data is used to study the intrinsic functional connectivity (FC) in the human brain. Recently, interest has focused on studying the temporal dynamics of FC on short timescales, ranging from seconds to minutes. These studies of time-varying FC (TVFC) have enabled the […]
Kavli Affiliate: Michael Miller | Authors: Paul Richard Yulo, Nicolas Desprat, Monica L. Gerth, Barbara Ritzl-Rinkenberger, Andrew D Farr, Yunhao Liu, Xue-Xian Zhang, Michael Miller, Felipe Cava, Paul B. Rainey and Heather L Hendrickson | Summary: Maintenance of rod-shape in bacterial cells depends on the actin-like protein MreB. Deletion of mreB from Pseudomonas fluorescens SBW25 […]
Kavli Affiliate: Xiaoqin Wang | Authors: Xindong Song, Yueqi Guo, Chenggang Chen, Jong Hoon Lee and Xiaoqin Wang | Summary: Tonotopic organization of the auditory cortex has been extensively studied in many mammalian species using various methodologies and physiological preparations. Tonotopy mapping in primates, however, is more limited due to constraints such as cortical folding, […]
Kavli Affiliate: Jin Kang | Authors: Sang-Hun Lee, Young-Jin Kang and Bret N Smith | Summary: Parvalbumin-positive (PV+) GABAergic interneurons in the dentate gyrus provide powerful perisomatic inhibition of dentate granule cells (DGCs) to prevent overexcitation and maintain the stability of dentate gyrus circuits. Most dentate PV+ interneurons survive status epilepticus, but surviving PV+ interneuron […]