Ketamine modulates a norepinephrine-astroglial circuit to persistently suppress futility-induced passivity

Kavli Affiliate: Dwight Bergles | First 5 Authors: Marc Duque, Alex B. Chen, Eric Hsu, Sujatha Narayan, Altyn Rymbek, Shahinoor Begum, Gesine Saher, Adam Ezra Cohen, David E. Olson, David A Prober, Dwight E Bergles, Mark C Fishman, Florian Engert and Misha B Ahrens | Summary: Mood-altering compounds hold promise for the treatment of many […]


Continue.. Ketamine modulates a norepinephrine-astroglial circuit to persistently suppress futility-induced passivity

Microbial aromatic amino acid metabolism is modifiable in fermented food matrices to promote bioactivity

Kavli Affiliate: Michael Miller | Authors: Mikaela C Kasperek, Adriana Velasquez Galeas, Maria Elisa Caetano-Silva, Zifan Xie, Alexander V Ulanov, Michael R La Frano, Suzanne Devkota, Michael J Miller and Jacob M Allen | Summary: Ingestion of fermented foods impacts human immune function, yet the bioactive food components underlying these effects are not understood. Here, […]


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A software tool for at-home measurement of sensorimotor adaptation

Kavli Affiliate: Reza Shadmehr | Authors: Jihoon Jang, Reza Shadmehr and Scott T Albert | Summary: Sensorimotor adaptation is traditionally studied in well-controlled laboratory settings with specialized equipment. However, recent public health concerns such as the COVID-19 pandemic, as well as a desire to recruit a more diverse study population, have led the motor control […]


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Three-dimensional assessments are necessary to determine the true spatial tissue composition of diseased tissues

Kavli Affiliate: Denis Wirtz | Authors: André Forjaz, Eduarda Vaz, Valentina Matos Romero, Saurabh Joshi, Alicia M. Braxton, Ann C. Jiang, Kohei Fujikura, Toby Cornish, Seung-Mo Hong, Ralph H. Hruban, Pei-Hsun Wu, Laura D. Wood, Ashley L. Kiemen and Denis Wirtz | Summary: Methods for partially resolved cellular profiling has enabled in-depth quantitative tissue mapping […]


Continue.. Three-dimensional assessments are necessary to determine the true spatial tissue composition of diseased tissues

Engineered Secretory Immunoglobulin A provides insights on antibody-based effector mechanisms targeting Clostridiodes difficile

Kavli Affiliate: Michael Miller | Authors: Sonya Kumar Bharathkar, Michael J. Miller and Beth M. Stadtmueller | Summary: Secretory (S) Immunoglobin (Ig) A is the predominant mucosal antibody, which mediates host interactions with commensal and pathogenic microbes, including Clostridioides difficile. SIgA adopts a polymeric IgA structure that is bound by secretory component (SC). Despite significance, […]


Continue.. Engineered Secretory Immunoglobulin A provides insights on antibody-based effector mechanisms targeting Clostridiodes difficile

An encyclopedia of enhancer-gene regulatory interactions in the human genome

Kavli Affiliate: Michael Beer | Authors: Andreas R. Gschwind, Kristy S. Mualim, Alireza Karbalayghareh, Maya U. Sheth, Kushal K. Dey, Evelyn Jagoda, Ramil N. Nurtdinov, Wang Xi, Anthony S. Tan, Hank Jones, X. Rosa Ma, David Yao, Joseph Nasser, Ziga Avsec, Benjamin T. James, Muhammad S. Shamim, Neva C. Durand, Suhas S. P. Rao, Ragini […]


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Microbiota-dependent early life programming of gastrointestinal motility

Kavli Affiliate: David Linden | Authors: Mary E Frith, Purna C Kashyap, David R Linden, Betty Theriault and Eugene B Chang | Summary: Gastrointestinal microbes modulate peristalsis and stimulate the enteric nervous system (ENS), whose development, as in the central nervous system (CNS), continues into the murine postweaning period. Given that adult CNS function depends […]


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Contexts facilitate dynamic value encoding in the mesolimbic dopamine system

Kavli Affiliate: Patricia Janak | Authors: Kurt Michael Fraser, Val L Collins, Amy R Wolff, David J Ottenheimer, Kaisa N Bornhoft, Fiona Pat, Bridget J Chen, Patricia H Janak and Benjamin T Saunders | Summary: Adaptive behavior in a dynamic environment often requires rapid revaluation of stimuli that deviates from well-learned associations. The divergence between […]


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Electric fields determine carbapenemase activity in class A β-lactamases

Kavli Affiliate: Michael Beer | Authors: Hira Jabeen, Michael Beer, James Spencer, Marc W van der Kamp, H Adrian Bunzel and Adrian J Mulholland | Summary: MAntimicrobial resistance is a public health crisis. Limited understanding of the catalytic drivers in resistance-mediating enzymes such as β-lactamases hinders our ability to combat this crisis. Here, we dissect […]


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Digitize your Biology! Modeling multicellular systems through interpretable cell behavior

Kavli Affiliate: Denis Wirtz | Authors: Jeanette A.I. Johnson, Genevieve L Stein-O’Brien, Max Booth, Randy Heiland, Furkan Kurtoglu, Daniel Bergman, Elmar Bucher, Atul Deshpande, Andre Forjaz, Michael Getz, Ines Godet, Melissa Lyman, John Metzcar, Jacob Mitchell, Andrew Raddatz, Heber L. Rocha, Jacobo Solorzano, Aneequa Sundus, Yafei Wang, Daniele M. Gilkes, Luciane T. Kagohara, Ashley L. […]


Continue.. Digitize your Biology! Modeling multicellular systems through interpretable cell behavior