Tonotopic organization of auditory cortex in awake marmosets revealed by multi-modal wide-field optical imaging

Kavli Affiliate: Xiaoqin Wang | Authors: Xindong Song, Yueqi Guo, Chenggang Chen, Jong Hoon Lee and Xiaoqin Wang | Summary: Tonotopic organization of the auditory cortex has been extensively studied in many mammalian species using various methodologies and physiological preparations. Tonotopy mapping in primates, however, is more limited due to constraints such as cortical folding, […]


Continue.. Tonotopic organization of auditory cortex in awake marmosets revealed by multi-modal wide-field optical imaging

Activation of hypoactive parvalbumin-positive fast-spiking interneuron restores dentate inhibition to prevent epileptiform activity in the mouse intrahippocampal kainate model of temporal lobe epilepsy

Kavli Affiliate: Jin Kang | Authors: Sang-Hun Lee, Young-Jin Kang and Bret N Smith | Summary: Parvalbumin-positive (PV+) GABAergic interneurons in the dentate gyrus provide powerful perisomatic inhibition of dentate granule cells (DGCs) to prevent overexcitation and maintain the stability of dentate gyrus circuits. Most dentate PV+ interneurons survive status epilepticus, but surviving PV+ interneuron […]


Continue.. Activation of hypoactive parvalbumin-positive fast-spiking interneuron restores dentate inhibition to prevent epileptiform activity in the mouse intrahippocampal kainate model of temporal lobe epilepsy

Three-dimensional reconstruction of fetal rhesus macaque kidneys at single-cell resolution reveals complex inter-relation of structures

Kavli Affiliate: Denis Wirtz | Authors: Lucie Dequiedt, Andre Forjaz, Jamie O. Lo, Owen J McCarty, Pei-Hsun Wu, Avi Rosenberg, Denis Wirtz and Ashley L. Kiemen | Summary: Kidneys are among the most structurally complex organs in the body. Their architecture is critical to ensure proper function and is often impacted by diseases such as […]


Continue.. Three-dimensional reconstruction of fetal rhesus macaque kidneys at single-cell resolution reveals complex inter-relation of structures

Foraging Under Uncertainty Follows the Marginal Value Theorem with Bayesian Updating of Environment Representations

Kavli Affiliate: Daeyeol Lee | Authors: James Webb, Paul Steffan, Benjamin Y Hayden, Daeyeol Lee, Caleb Kemere and Matthew McGinley | Summary: Foraging theory has been a remarkably successful approach to understanding the behavior of animals in many contexts. In patch-based foraging contexts, the marginal value theorem (MVT) shows that the optimal strategy is to […]


Continue.. Foraging Under Uncertainty Follows the Marginal Value Theorem with Bayesian Updating of Environment Representations

Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function

Kavli Affiliate: Kathleen Cullen | Authors: Kazuya Ono, Amandine Jarysta, Natasha Hughes, Alma Jukic, Vanessa H.H. Chang, Michael R Deans, Ruth Anne Eatock, Kathleen E Cullen, Katie S Kindt and Basile Tarchini | Summary: Otolith organs in the inner ear and neuromasts in the fish lateral-line harbor two populations of hair cells oriented to detect […]


Continue.. Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function

Three-dimensional assessments are necessary to determine the true, spatially-resolved composition of tissues

Kavli Affiliate: Denis Wirtz | Authors: André Forjaz, Eduarda Vaz, Valentina Matos Romero, Saurabh Joshi, Alicia M. Braxton, Ann C. Jiang, Kohei Fujikura, Toby Cornish, Seung-Mo Hong, Ralph H. Hruban, Pei-Hsun Wu, Laura D. Wood, Ashley L. Kiemen and Denis Wirtz | Summary: Methods for spatially resolved cellular profiling using thinly cut sections have enabled […]


Continue.. Three-dimensional assessments are necessary to determine the true, spatially-resolved composition of tissues

Generative interpolation and restoration of images using deep learning for improved 3D tissue mapping

Kavli Affiliate: Denis Wirtz | Authors: Saurabh Joshi, André Forjaz, Kyu Sang Han, Yu Shen, Daniel Xenes, Jordan Matelsky, Brock Wester, Arrate Munoz-Barrutia, Ashley L Kiemen, Pei-Hsun Wu and Denis Wirtz | Summary: The development of novel imaging platforms has improved our ability to collect and analyze large three-dimensional (3D) biological imaging datasets. Advances in […]


Continue.. Generative interpolation and restoration of images using deep learning for improved 3D tissue mapping

A 3D in vitro assay to study combined immune cell infiltration and cytotoxicity

Kavli Affiliate: Denis Wirtz | Authors: Ashleigh J Crawford, Adrian Johnston, Wenxuan Du, Eban A Hanna, David Schell, Zeqi Wan, Ting-Hsi Chen, Fan Wu, Kehan Ren, Yeongseo Lim, Praful R Nair and Denis Wirtz | Summary: Immune cell-mediated killing of cancer cells in a solid tumor is prefaced by a multi-step infiltration cascade of invasion, […]


Continue.. A 3D in vitro assay to study combined immune cell infiltration and cytotoxicity

Small extracellular vesicles promote stiffness-mediated metastasis

Kavli Affiliate: Denis Wirtz | Authors: Alexandra Sneider, Ying Liu, Bartholomew Starich, Wenxuan Du, Carolyn Marar, Najwa Faqih, Gabrielle E Ciotti, Joo Ho Kim, Sejal Krishnan, Salma Ibrahim, Muna Igboko, Alexus Locke, Daniel M Lewis, Hanna Hong, Michelle Karl, Raghav Vij, Gabriella C Russo, Praful R Nair, Estibaliz Gómez-de-Mariscal, Mehran Habibi, Arrate Munoz-Barrutia, Luo Gu, […]


Continue.. Small extracellular vesicles promote stiffness-mediated metastasis