SLAy-ing oversplitting errors in high-density electrophysiology spike sorting

Kavli Affiliate: Adam S. Charles and Kathleen Cullen | Authors: Sai Koukuntla, Tate DeWeese, Alexandra Cheng, Robyn Mildren, Aamna Lawrence, Austin R Graves, Kathleen E Cullen, Jennifer Colonell, Timothy D Harris and Adam S Charles | Summary: The growing channel count of silicon probes has substantially increased the number of neurons recorded in electrophysiology (ephys) […]


Continue.. SLAy-ing oversplitting errors in high-density electrophysiology spike sorting

Impact of Alzheimer’s disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus

Kavli Affiliate: Keri Martinowich | Authors: Bernard Mulvey, Heena R Divecha, Madhavi Tippani, Svitlana V Bach, Rahul Bharadwaj, Ishbel Del Rosario, Sarah E Maguire, Ryan A Miller, Aaron J Salisbury, Atharv Chandra, Beau A Oster, Kelsey D Montgomery, Sang Ho Kwon, Haya A Algrain, Alexis R Papariello, Louise A Huuki-Myers, Joel E Kleinman, Leonardo Collado-Torres, […]


Continue.. Impact of Alzheimer’s disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus

CRISPR-mediated transcriptional activation as a mutation-independent therapeutic strategy for SYNGAP1-related intellectual disability

Kavli Affiliate: Richard Huganir | Authors: Laura Sichlinger, Molly Reilly, Sakshi Arora, Shuo Zhang, Nicolas Marotta, Kiara L. Rodriguez-Acevedo, Marisol Hooks, Kyle S. Czarnecki, Julia J. Winter, Elisa A. Waxman, Lea V. Dungan, Ingie Hong, Yoichi Araki, Richard Johnson, Richard L. Huganir, Giulia Pavani, Deborah L. French, Beverly L. Davidson, Benjamin L. Prosser and Elizabeth […]


Continue.. CRISPR-mediated transcriptional activation as a mutation-independent therapeutic strategy for SYNGAP1-related intellectual disability

Exploiting Endogenous CRISPR-Cas9 System for Functional Engineering of Probiotic Lacticaseibacillus rhamnosus GG (LGG)

Kavli Affiliate: Michael Miller | Authors: Zifan Xie, Yong-Su Jin and Michael J Miller | Summary: Lacticaseibacillus rhamnosus GG (LGG) is one of the most extensively studied probiotic strains, widely used in food and health applications. However, the absence of efficient, precise genome editing methods has limited its broader potential and functional versatility. Here, we […]


Continue.. Exploiting Endogenous CRISPR-Cas9 System for Functional Engineering of Probiotic Lacticaseibacillus rhamnosus GG (LGG)

Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels.

Kavli Affiliate: Seth Blackshaw | Authors: Kurt Weir, Pin Lyu, Sangeetha Kandoi, Roujin An, Nicole Pannullo, Isabella Palazzo, Jared Tangeman, Jun Shi, Steven DeVries, Dana Merriman, Jiang Qian and Seth Blackshaw | Summary: Evolutionary adaptation to diurnal vision in ground squirrels has led to the development of a cone-dominant retina, in stark contrast to the […]


Continue.. Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels.

Improved inference of latent neural states from calcium imaging data

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Adam S. Charles | Authors: Stephen Keeley, David M Zoltowski, Adam Charles and Jonathan W Pillow | Summary: Calcium imaging (CI) is a standard method for recording neural population activity, as it enables simultaneous recording of hundreds-to-thousands of individual somatic […]


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Parallel circadian-like oscillations in LTP and excitation inhibition balance in mouse CA1 reverse direction after puberty

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Michela Gallagher | Authors: gonzalo valdivia, cristian moreno, Kaiwen He, darwin contreras, Trinh tran, Anthony D Ramnaugh, William Xu, Altagracia Contreras, Diego C Fernandez, Daniel Severin, Samer Hattar, Michela Gallagher and alfredo kirkwood | Summary: Long-term potentiation (LTP), the best-characterized […]


Continue.. Parallel circadian-like oscillations in LTP and excitation inhibition balance in mouse CA1 reverse direction after puberty

Uncertainty-Gated Min-Cost Flows for In Vivo NanoScale Synaptic Plasticity Tracking

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Richard Huganir, Adam S. Charles and Michael Miller | Authors: Shashwat Kumar, Gabrielle I Coste, Dasun Premathilaka, Richard L. Huganir, Austin R Graves, Adam S Charles and Michael I Miller | Summary: Synapses are the fundamental unit of neural connectivity. […]


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Synchronized path-integration recalibration but distinct landmark-control dynamics in head direction and CA1 place cells

Kavli Affiliate: James Knierim | Authors: Ravikrishnan P Jayakumar, Yotaro Sueoka, Marissa K Ferreyros, Brian Y Li, Manu S Madhav, Xingyu Chen, James J Knierim and Noah J Cowan | Summary: Accurate spatial navigation relies on path integration, a process of tracking one’s location by integrating self-motion cues. Path integration uses a gain factor relating […]


Continue.. Synchronized path-integration recalibration but distinct landmark-control dynamics in head direction and CA1 place cells

Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation

Kavli Affiliate: Jeremy Nathans | Authors: Yanshu Wang, Amir Rattner, Zhongming Li, Philip M Smallwood and Jeremy Nathans | Summary: In mice, postnatal endothelial cell (EC)-specific knockout of the genes coding for Transforming Growth Factor-Beta Receptor (TGFBR)1 and/or TGFBR2 eliminates TGF-beta signaling in vascular ECs and leads to distinctive central nervous system (CNS) vascular phenotypes. […]


Continue.. Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation