Pathogenic tau in the mouse locus coeruleus induces noradrenergic hyperactivity and neuropsychiatric phenotypes reminiscent of early Alzheimers disease

Posted by dbos Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Anu Korukonda, Harris E Blankenship, Korey Kam, Dilpreet Kour, Claudia Espinosa-Garcia, Wooyoung Eric Jang, Upsana Srivastava, Bernard Mulvey, Margaret M Tish, Ronit Witztum, Christina C Ramelow, Brittany S Pate, L Cameron Liles, Linyue Lu, Jake Atallah, Eugene Guo, Keri Martinowich, Amanda L Sharpe, Andrew Varga, Srikant Rangaraju, Michael J […]


Continue.. Pathogenic tau in the mouse locus coeruleus induces noradrenergic hyperactivity and neuropsychiatric phenotypes reminiscent of early Alzheimers disease

Astrocyte redox imbalance underlies prelimbic neuronal hypoactivity and affective behavior in epilepsy

Posted by dbos Hopkins

Kavli Affiliate: Dwight Bergles | Authors: Travis E Faust, Atsushi Saito, Shoichi Ishikawa, Kun Yang, Wendy Xin, Ho Namkung, Amit Agarwal, Adriana Ramos, Brian J Lee, Lindsay Hayes, Rupali Srivastava, Sunday Adelakun, Sneha Saha, Trexy Palen, Tyler Cash-Padgett, Daniel Wood, Elisa Carloni, Ryosuke Yusa, Hanna Jaaro-Peled, Jed W Fahey, Dwight E Bergles, Koko Ishizuka and […]


Continue.. Astrocyte redox imbalance underlies prelimbic neuronal hypoactivity and affective behavior in epilepsy

Evidence of off-target probe binding affecting 10x Genomics Xenium gene panels compromise accuracy of spatial transcriptomic profiling

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Kavli Affiliate: Jean Fan | Authors: Caleb Hallinan, Hyun Joo Ji, Edmund Tsou, Steven L Salzberg and Jean Fan | Summary: The accuracy of spatial gene expression profiles generated by probe-based in situ spatially-resolved transcriptomic technologies depends on the specificity with which probes bind to their intended target gene. Off-target binding, defined as a probe […]


Continue.. Evidence of off-target probe binding affecting 10x Genomics Xenium gene panels compromise accuracy of spatial transcriptomic profiling

Activating Ras-MAPK pathway variants drive hippocampal clonal competition in human epilepsy

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Kavli Affiliate: Michael Miller | Authors: Sattar Khoshkhoo, Mingyun Bae, Yilan Wang, Ashton Tillett, Rosita B. Ramirez, Benjamin Finander, Emily D. Egan, Linus Marx, Dipan Patel, Zinan Zhou, Yasmine Chahine, Brian Chhouk, Sofia M. Zoullas, Abbe Lai, Roland Coras, Franck Bielle, Vincent Navarro, Bertrand Mathon, Taufik A. Valiante, Homeira Moradi Chameh, Andrew F. Gao, Timo […]


Continue.. Activating Ras-MAPK pathway variants drive hippocampal clonal competition in human epilepsy

Spatially-resolved molecular sex differences at single cell resolution in the adult human ventromedial and arcuate hypothalamus

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Kavli Affiliate: Keri Martinowich | Authors: Bernard Mulvey, Yi Wang, Heena R Divecha, Svitlana V Bach, Kelsey D Montgomery, Sophia Cinquemani, Atharv Chandra, Yufeng Du, Ryan A Miller, Joel E Kleinman, Stephanie Cerceo Page, Thomas M Hyde, Keri Martinowich, Stephanie C Hicks, Kasper D Hansen and Kristen R Maynard | Summary: The hypothalamus contains multiple […]


Continue.. Spatially-resolved molecular sex differences at single cell resolution in the adult human ventromedial and arcuate hypothalamus

Statistically valid explainable black-box machine learning: applications in sex classification across species using brain imaging

Posted by dbos Hopkins

Kavli Affiliate: Joshua Vogelstein | Authors: Tingshan Liu, Jayanta Dey, Beiya Xu, Eric W. Bridgeford, Samuel S Alldritt, Karl-Heinz Nenning, Kyoungseob Byeon, Ting Xu and Joshua T. Vogelstein | Summary: Sex classification using neuroimaging data has the potential to revolutionize personalized diagnostics by revealing subtle structural brain differences that underlie sex-specific disease risks. Despite the […]


Continue.. Statistically valid explainable black-box machine learning: applications in sex classification across species using brain imaging

Versatile high-speed volumetric imaging from microscopic to macroscopic scale by self-adaptive oblique plane microscopy

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Kavli Affiliate: Dwight Bergles | Authors: Dominique Meyer, Grant Kroeschell, Xiankun Lu, Linh Hoang, Haochen Wang, Shuying Li, Yu Kang T Xu, Lei Tan, Jeff S Mumm, Dwight E Bergles and Ji Yi | Summary: There is an increasing need for large-scale high-speed volumetric recording in complex multi-cellular model systems to define dynamic processes. Oblique […]


Continue.. Versatile high-speed volumetric imaging from microscopic to macroscopic scale by self-adaptive oblique plane microscopy

Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels.

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Kavli Affiliate: Seth Blackshaw | Authors: Kurt Weir, Pin Lyu, Sangeetha Kandoi, Roujin An, Nicole Pannullo, Isabella Palazzo, Jared Tangeman, Jun Shi, Steven DeVries, Dana Merriman, Jiang Qian and Seth Blackshaw | Summary: Evolutionary adaptation to diurnal vision in ground squirrels has led to the development of a cone-dominant retina, in stark contrast to the […]


Continue.. Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels.

Sox8 and Sox9 regulate differentiation and nuclear positioning of retinal Muller glia.

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Kavli Affiliate: Seth Blackshaw | Authors: Nicole Pannullo, Debarpita Datta, Clayton Santiago, Jared Tangeman, Lizhi Jiang, Leighton Duncan and Seth Blackshaw | Summary: Temporal patterning of retinal progenitor cells governs the sequential generation of retinal cell types, with gliogenesis occurring late in development. Sox8 and Sox9, members of the SoxE transcription factor family, are highly […]


Continue.. Sox8 and Sox9 regulate differentiation and nuclear positioning of retinal Muller glia.

Protein tyrosine phosphatase receptor type kappa (PTPRκ) regulates Superior ON-Direction Selective Ganglion Cell development, facilitating image stabilization

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Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Alex Kolodkin | Authors: Tzu-Huai Lin, Annika Balraj, Timour Al-Khindi, James K Kiraly, Felice A Dunn and Alex L Kolodkin | Summary: In vertebrates, gaze stabilization during global visual motion requires ON direction-selective ganglion cells (oDSGCs) in the Accessory Optic […]


Continue.. Protein tyrosine phosphatase receptor type kappa (PTPRκ) regulates Superior ON-Direction Selective Ganglion Cell development, facilitating image stabilization