Kavli Affiliate: Denis Wirtz | Authors: Xinyun Jiang, Vasco Queiroga, Eban A Hanna and Denis Wirtz | Summary: Limited infiltration capacity significantly limits the effectiveness of chimeric antigen receptor (CAR) T cells for solid tumors. We have recently developed a large family of highly modular synthetic cytokine receptors termed velocity receptors (VRs), capable of binding […]
Kavli Affiliate: Jin Kang | Authors: Abdullah Ozer, Jin Joo Kang, Yuliang Tang, Kumar Yugandhar, Yu Sun, Michael D DeBerardine, Karim Omar, John Lis and Haiyuan Yu | Summary: RNA Polymerase II (Pol II) transcription is highly regulated at two early steps in the transcription cycle: Pre-Initiation Complex (PIC) assembly with its coupled initiation, and […]
Kavli Affiliate: Xiaoqin Wang | Authors: Mohamad Azhar, Mengistu G Gebere, Mrinmay Chakrabarti, Aamina Azhar, Xiaoqin Wang, Narendra R Vyavahare and John Johnson | Summary: Objective Thoracic aortic aneurysm and dissection (TAAD) are major complications of Loeys- Dietz syndrome caused by heterozygous TGFB2 mutations. While Tgfb2 knockout mice die at birth and adult heterozygotes develop […]
Kavli Affiliate: Michael Miller | Authors: Alessandra Castaldi, Ji Sun Chin, Benjamin Ma, Max W Chang, Kayla Samimi, Alexa Allen, William Pinon-Rose, Jonathan Castillo, Parham Zamani, Mindy Xie, Nataly Arias, Kayvon Solaimanpour, Yixin Liu, Hua Shen, Brian T Scott, Masafumi Horie, Per Flodby, Ana Kasirer-Friede, Kelsey Dang, Justin Buchanan, Ryan Lancione, Michael Miller, Qiang Yang, […]
Kavli Affiliate: Denis Wirtz | Authors: Florin Selaru, Jude Phillip, Denis Wirtz and Pei-Hsun Wu | Summary: Advancements in computational approaches have enabled robust utilization of histological tissue data. A crucial step in the development of computational tools for the objective and quantitative analysis of tissue sections has been color deconvolution. Color deconvolution functions by […]
Kavli Affiliate: Jin Kang | Authors: Shiying Huang, Yeun Ju Kim, Xiaofu Cao, Timothy W Bumpus, Mira Sohn, Matthew Tyler Menold, Ryan S Dale, Jin Joo Kang, Saori Uematsu, Shagun Gupta, Shu-Bing Qian, Haiyuan Yu, Tamas Balla and Jeremy M Baskin | Summary: Cells tightly control the homeostatic levels and subcellular localizations of membrane phospholipids […]
Kavli Affiliate: Marshall Hussain Shuler | Authors: Elissa Sutlief, Shichen Zhang, Kate Forsberg, Rie Kaneko and Marshall G Hussain Shuler | Summary: Activities with diminishing returns pose a unique computational problem for the brain, requiring a combination of outcome evaluation and temporal tracking. Deciding the right time to stop one pursuit and move to alternatives […]
Kavli Affiliate: Martin Lindquist | Authors: Patrick Sadil and Martin A. Lindquist | Summary: Task-based functional magnetic resonance imaging (fMRI) is a powerful tool for studying brain function. However, the reliability and viability of small-sample studies remain a concern. While it is well understood that larger samples are preferable, researchers often need to interpret findings […]
Kavli Affiliate: Denis Wirtz | Authors: Praful R Nair, Eban Hanna, Saurabh Joshi, Victoria Duarte Alvarado, Challice Bonifant and Denis Wirtz | Summary: Cellular immunotherapy has shown remarkable efficacy in hematological malignancies but remains limited by infiltration issues in solid tumors, leading to poor treatment efficacy. We have recently shown that mesothelin-targeting CAR T cells […]
Kavli Affiliate: Seth Blackshaw | Authors: Haley Appel, Rogger Carmen-Orozco, Clayton Santiago, Thanh Hoang and Seth Blackshaw | Summary: The RNA-binding protein Ptbp1 has been proposed as a master regulator of neuronal fate, repressing neurogenesis through its effects on alternative splicing and miRNA maturation. While prior studies using RNA interference suggested that Ptbp1 loss promotes […]