EEG responses to rapidly unfolding stochastic sounds reflect precision tracking

Kavli Affiliate: Mounya Elhilali | Authors: Sijia Zhao, Benjamin Skerritt-Davis, Mounya Elhilali, Frederic Dick and Maria Chait | Summary: The brain is increasingly viewed as a statistical learning machine, where our sensations and decisions arise from the intricate interplay between bottom-up sensory signals and constantly changing expectations regarding the surrounding world. Which statistics does the […]


Continue.. EEG responses to rapidly unfolding stochastic sounds reflect precision tracking

A Causal Perspective for Batch Effects: When is no answer better than a wrong answer?

Kavli Affiliate: Brian Caffo and Joshua Vogelstein | Authors: Eric W. Bridgeford, Michael Powell, Gregory Kiar, Stephanie Noble, Jaewon Chung, Sambit Panda, Ross Lawrence, Ting Xu, Michael Milham, Brian Caffo and Joshua T. Vogelstein | Summary: Batch effects, undesirable sources of variance across multiple experiments, present significant challenges for scientific and clinical discoveries. Specifically, batch […]


Continue.. A Causal Perspective for Batch Effects: When is no answer better than a wrong answer?

Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer’s disease microglia

Kavli Affiliate: Michael Miller | Authors:August Yue Huang, Zinan Zhou, Maya Talukdar, Michael B Miller, Brian Chhouk, Liz Enyenihi, Ila Rosen, Edward Stronge, Boxun Zhao, Dachan Kim, Jaejoon Choi, Sattar Khoshkhoo, Junho Kim, Javier Ganz, Kyle J Travaglini, Mariano Gabitto, Rebecca D Hodge, Eitan Kaplan, Ed Lein, Phillip De Jager, David A Bennett, Eunjung Alice […]


Continue.. Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer’s disease microglia

Basolateral amygdala population coding of a cued reward seeking state depends on orbitofrontal cortex

Kavli Affiliate: Patricia Janak | David J Ottenheimer, Katherine R Vitale, Frederic Ambroggi, Patricia H Janak and Benjamin T Saunders | Summary: Basolateral amygdala (BLA) neuronal responses to conditioned stimuli are closely linked to the expression of conditioned behavior. An area of increasing interest is how the dynamics of BLA neurons relate to evolving behavior. […]


Continue.. Basolateral amygdala population coding of a cued reward seeking state depends on orbitofrontal cortex

Ketamine modulates a norepinephrine-astroglial circuit to persistently suppress futility-induced passivity

Kavli Affiliate: Dwight Bergles | First 5 Authors: Marc Duque, Alex B. Chen, Eric Hsu, Sujatha Narayan, Altyn Rymbek, Shahinoor Begum, Gesine Saher, Adam Ezra Cohen, David E. Olson, David A Prober, Dwight E Bergles, Mark C Fishman, Florian Engert and Misha B Ahrens | Summary: Mood-altering compounds hold promise for the treatment of many […]


Continue.. Ketamine modulates a norepinephrine-astroglial circuit to persistently suppress futility-induced passivity

Microbial aromatic amino acid metabolism is modifiable in fermented food matrices to promote bioactivity

Kavli Affiliate: Michael Miller | Authors: Mikaela C Kasperek, Adriana Velasquez Galeas, Maria Elisa Caetano-Silva, Zifan Xie, Alexander V Ulanov, Michael R La Frano, Suzanne Devkota, Michael J Miller and Jacob M Allen | Summary: Ingestion of fermented foods impacts human immune function, yet the bioactive food components underlying these effects are not understood. Here, […]


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A software tool for at-home measurement of sensorimotor adaptation

Kavli Affiliate: Reza Shadmehr | Authors: Jihoon Jang, Reza Shadmehr and Scott T Albert | Summary: Sensorimotor adaptation is traditionally studied in well-controlled laboratory settings with specialized equipment. However, recent public health concerns such as the COVID-19 pandemic, as well as a desire to recruit a more diverse study population, have led the motor control […]


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Three-dimensional assessments are necessary to determine the true spatial tissue composition of diseased tissues

Kavli Affiliate: Denis Wirtz | Authors: AndrĂ© Forjaz, Eduarda Vaz, Valentina Matos Romero, Saurabh Joshi, Alicia M. Braxton, Ann C. Jiang, Kohei Fujikura, Toby Cornish, Seung-Mo Hong, Ralph H. Hruban, Pei-Hsun Wu, Laura D. Wood, Ashley L. Kiemen and Denis Wirtz | Summary: Methods for partially resolved cellular profiling has enabled in-depth quantitative tissue mapping […]


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Engineered Secretory Immunoglobulin A provides insights on antibody-based effector mechanisms targeting Clostridiodes difficile

Kavli Affiliate: Michael Miller | Authors: Sonya Kumar Bharathkar, Michael J. Miller and Beth M. Stadtmueller | Summary: Secretory (S) Immunoglobin (Ig) A is the predominant mucosal antibody, which mediates host interactions with commensal and pathogenic microbes, including Clostridioides difficile. SIgA adopts a polymeric IgA structure that is bound by secretory component (SC). Despite significance, […]


Continue.. Engineered Secretory Immunoglobulin A provides insights on antibody-based effector mechanisms targeting Clostridiodes difficile

An encyclopedia of enhancer-gene regulatory interactions in the human genome

Kavli Affiliate: Michael Beer | Authors: Andreas R. Gschwind, Kristy S. Mualim, Alireza Karbalayghareh, Maya U. Sheth, Kushal K. Dey, Evelyn Jagoda, Ramil N. Nurtdinov, Wang Xi, Anthony S. Tan, Hank Jones, X. Rosa Ma, David Yao, Joseph Nasser, Ziga Avsec, Benjamin T. James, Muhammad S. Shamim, Neva C. Durand, Suhas S. P. Rao, Ragini […]


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