Kavli Affiliate: Michael Miller | Authors: Nidhi Nandu, Michael Miller, Yanhong Tong and Zhi-xiang Lu | Summary: Cost efficient and rapid detection tools to detect mutations especially those linked to drug-resistance are important to address concerns of the rising multi-drug resistance infections. Here we integrated dual probes, namely a calibrator probe and an indicator probe, […]
Kavli Affiliate: Denis Wirtz | Authors: Geonhui Lee, Claudia Wong, Anna Cho, Junior J. West, Ashleigh J. Crawford, Gabriella C. Russo, Bishwa Ranjan Si, Jungwoo Kim, Lauren Hoffner, Cholsoon Jang, Moonjung Jung, Robert D. Leone, Konstantinos Konstantopoulos, Andrew J. Ewald, Denis Wirtz and Sangmoo Jeong | Summary: The loss of E-cadherin (E-cad), an epithelial cell […]
Kavli Affiliate: Kathleen Cullen | Authors: Cynthia R Steinhardt, Diana E Mitchell, Kathleen E Cullen and Gene Y Fridman | Summary: Electrical stimulation is a key tool in neuroscience, both in brain mapping studies and in many therapeutic applications such as cochlear, vestibular, and retinal neural implants. Due to safety considerations, stimulation is restricted to […]
Kavli Affiliate: James Knierim | Authors: Gorkem Secer, James J. Knierim and Noah J. Cowan | Summary: Representations of continuous variables are crucial to create internal models of the external world. A prevailing model of how the brain maintains these representations is given by continuous bump attractor networks (CBANs) in a broad range of brain […]
Kavli Affiliate: Adam S. Charles | Authors: Victor Geadah, G. Barello, Adam Charles and Jonathan Pillow | Summary: The sparse coding model posits that the visual system has evolved to efficiently code natural stimuli using a sparse set of features from an overcomplete dictionary. The original sparse coding model suffered from two key limitations, however: […]
Kavli Affiliate: Damon Clark | Authors: Patricia Janak | Summary: Cues paired with alcohol can be potent drivers of craving, alcohol-seeking, consumption, and relapse. While the ventral pallidum is implicated in appetitive and consummatory responses across several reward classes and types of behaviors, its role in behavioral responses to Pavlovian alcohol cues has not previously […]
Kavli Affiliate: Xingde Li | Authors: Wenxuan Liang, Yuehan Liu, Honghua Guan, Vorada Sakulsaengprapha, Katherine Luby-Phelps, Mala Mahendroo and Xingde Li | Summary: Background Preterm birth (PTB) is a global public health issue affecting millions of newborns every year. Orchestrated remodeling of the cervix is essential for normal pregnancy and birth, while PTB is closely […]
Kavli Affiliate: Seth Blackshaw | Authors: Qiang Liu, Jiali Xiong, Dong Won Kim, Sang Soo Lee, Benjamin J. Bell, Chloe Alexandre, Seth Blackshaw, Alban Latremoliere and Mark N. Wu | Summary: Circadian rhythms are generated by the master pacemaker suprachiasmatic nucleus (SCN), in concert with local clocks throughout the body. While many brain regions exhibit […]
Kavli Affiliate: Richard Huganir | Authors: Thomas L Dunham, Julia R Wilkerson, Richard C Johnson, Richard L. Huganir and Lenora J Volk | Summary: WWC2 (WW and C2 domain-containing protein) is implicated in several neurological disorders, however its function in the brain has yet to be determined. Here, we demonstrate that WWC2 interacts with inhibitory […]
Kavli Affiliate: Daeyeol Lee and Patricia Janak | Authors: Yifeng Cheng, Robin Magnard, Angela Langdon, Daeyeol Lee and Patricia H. Janak | Summary: Lack of cognitive flexibility is a hallmark of substance use disorders and has been associated with drug-induced synaptic plasticity in the dorsomedial striatum (DMS). Yet the possible impact of altered plasticity on […]