Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer’s disease microglia

Kavli Affiliate: Michael Miller | Authors:August Yue Huang, Zinan Zhou, Maya Talukdar, Michael B Miller, Brian Chhouk, Liz Enyenihi, Ila Rosen, Edward Stronge, Boxun Zhao, Dachan Kim, Jaejoon Choi, Sattar Khoshkhoo, Junho Kim, Javier Ganz, Kyle J Travaglini, Mariano Gabitto, Rebecca D Hodge, Eitan Kaplan, Ed Lein, Phillip De Jager, David A Bennett, Eunjung Alice […]


Continue.. Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer’s disease microglia

Basolateral amygdala population coding of a cued reward seeking state depends on orbitofrontal cortex

Kavli Affiliate: Patricia Janak | David J Ottenheimer, Katherine R Vitale, Frederic Ambroggi, Patricia H Janak and Benjamin T Saunders | Summary: Basolateral amygdala (BLA) neuronal responses to conditioned stimuli are closely linked to the expression of conditioned behavior. An area of increasing interest is how the dynamics of BLA neurons relate to evolving behavior. […]


Continue.. Basolateral amygdala population coding of a cued reward seeking state depends on orbitofrontal cortex

Ketamine modulates a norepinephrine-astroglial circuit to persistently suppress futility-induced passivity

Kavli Affiliate: Dwight Bergles | First 5 Authors: Marc Duque, Alex B. Chen, Eric Hsu, Sujatha Narayan, Altyn Rymbek, Shahinoor Begum, Gesine Saher, Adam Ezra Cohen, David E. Olson, David A Prober, Dwight E Bergles, Mark C Fishman, Florian Engert and Misha B Ahrens | Summary: Mood-altering compounds hold promise for the treatment of many […]


Continue.. Ketamine modulates a norepinephrine-astroglial circuit to persistently suppress futility-induced passivity

Microbial aromatic amino acid metabolism is modifiable in fermented food matrices to promote bioactivity

Kavli Affiliate: Michael Miller | Authors: Mikaela C Kasperek, Adriana Velasquez Galeas, Maria Elisa Caetano-Silva, Zifan Xie, Alexander V Ulanov, Michael R La Frano, Suzanne Devkota, Michael J Miller and Jacob M Allen | Summary: Ingestion of fermented foods impacts human immune function, yet the bioactive food components underlying these effects are not understood. Here, […]


Continue.. Microbial aromatic amino acid metabolism is modifiable in fermented food matrices to promote bioactivity

A software tool for at-home measurement of sensorimotor adaptation

Kavli Affiliate: Reza Shadmehr | Authors: Jihoon Jang, Reza Shadmehr and Scott T Albert | Summary: Sensorimotor adaptation is traditionally studied in well-controlled laboratory settings with specialized equipment. However, recent public health concerns such as the COVID-19 pandemic, as well as a desire to recruit a more diverse study population, have led the motor control […]


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Three-dimensional assessments are necessary to determine the true spatial tissue composition of diseased tissues

Kavli Affiliate: Denis Wirtz | Authors: AndrĂ© Forjaz, Eduarda Vaz, Valentina Matos Romero, Saurabh Joshi, Alicia M. Braxton, Ann C. Jiang, Kohei Fujikura, Toby Cornish, Seung-Mo Hong, Ralph H. Hruban, Pei-Hsun Wu, Laura D. Wood, Ashley L. Kiemen and Denis Wirtz | Summary: Methods for partially resolved cellular profiling has enabled in-depth quantitative tissue mapping […]


Continue.. Three-dimensional assessments are necessary to determine the true spatial tissue composition of diseased tissues

Engineered Secretory Immunoglobulin A provides insights on antibody-based effector mechanisms targeting Clostridiodes difficile

Kavli Affiliate: Michael Miller | Authors: Sonya Kumar Bharathkar, Michael J. Miller and Beth M. Stadtmueller | Summary: Secretory (S) Immunoglobin (Ig) A is the predominant mucosal antibody, which mediates host interactions with commensal and pathogenic microbes, including Clostridioides difficile. SIgA adopts a polymeric IgA structure that is bound by secretory component (SC). Despite significance, […]


Continue.. Engineered Secretory Immunoglobulin A provides insights on antibody-based effector mechanisms targeting Clostridiodes difficile

An encyclopedia of enhancer-gene regulatory interactions in the human genome

Kavli Affiliate: Michael Beer | Authors: Andreas R. Gschwind, Kristy S. Mualim, Alireza Karbalayghareh, Maya U. Sheth, Kushal K. Dey, Evelyn Jagoda, Ramil N. Nurtdinov, Wang Xi, Anthony S. Tan, Hank Jones, X. Rosa Ma, David Yao, Joseph Nasser, Ziga Avsec, Benjamin T. James, Muhammad S. Shamim, Neva C. Durand, Suhas S. P. Rao, Ragini […]


Continue.. An encyclopedia of enhancer-gene regulatory interactions in the human genome

Microbiota-dependent early life programming of gastrointestinal motility

Kavli Affiliate: David Linden | Authors: Mary E Frith, Purna C Kashyap, David R Linden, Betty Theriault and Eugene B Chang | Summary: Gastrointestinal microbes modulate peristalsis and stimulate the enteric nervous system (ENS), whose development, as in the central nervous system (CNS), continues into the murine postweaning period. Given that adult CNS function depends […]


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Contexts facilitate dynamic value encoding in the mesolimbic dopamine system

Kavli Affiliate: Patricia Janak | Authors: Kurt Michael Fraser, Val L Collins, Amy R Wolff, David J Ottenheimer, Kaisa N Bornhoft, Fiona Pat, Bridget J Chen, Patricia H Janak and Benjamin T Saunders | Summary: Adaptive behavior in a dynamic environment often requires rapid revaluation of stimuli that deviates from well-learned associations. The divergence between […]


Continue.. Contexts facilitate dynamic value encoding in the mesolimbic dopamine system