Mapping spatial gradients in spatial transcriptomics data with score matching

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Laurent Younes | Authors: An Wang, Donald Geman, Uthsav Chitra and Laurent Younes | Summary: Spatial transcriptomics (ST) technologies measure gene expression at thousands of locations within a two-dimensional tissue slice, enabling the study of spatial gene expression patterns. Spatial […]


Continue.. Mapping spatial gradients in spatial transcriptomics data with score matching

STcompare: comparative spatial transcriptomics data analysis of structurally matched tissues to characterize differentially spatially patterned genes

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Jean Fan | Authors: Kalen Clifton, Vivien Jiang, Rafael dos Santos Peixoto, Srujan Singh, Ryo Matsuura, Hamid Rabb and Jean Fan | Summary: Comparative analysis of spatial transcriptomics (ST) data is needed to identify genes that spatially change in their […]


Continue.. STcompare: comparative spatial transcriptomics data analysis of structurally matched tissues to characterize differentially spatially patterned genes

Sex and experience dependent regulation of synaptic protein turnover

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Richard Huganir | Authors: Seok Heo, Shiyu Zhang, Dong-Gi Mun, Akhilesh Pandey, Alexei M Bygrave and Richard L. Huganir | Summary: Synaptic transmission can be carefully tuned through plasticity mechanisms that regulate synaptic strength, structure, and number. In vivo measurements […]


Continue.. Sex and experience dependent regulation of synaptic protein turnover

APOE E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Keri Martinowich | Authors: Louise A. Huuki-Myers, Heena R. Divecha, Svitlana V. Bach, Madeline R. Valentine, Nicholas J. Eagles, Bernard Mulvey, Rahul A. Bharadwaj, Ruth Zhang, James R. Evans, Melissa Grant-Peters, Ryan A. Miller, Joel E. Kleinman, Shizhong Han, Thomas […]


Continue.. APOE E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex

CUSP: Complex Spike Sorting from Multi-electrode Array Recordings with U-net Sequence-to-Sequence Prediction

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Kathleen Cullen | Authors: Chenhao Bao, Robyn Mildren, Adam Charles and Kathleen E Cullen | Summary: Background Complex spikes (CSs) in cerebellar Purkinje cells convey unique signals complementary to Simple spike (SS) action potentials, but are infrequent and variable in […]


Continue.. CUSP: Complex Spike Sorting from Multi-electrode Array Recordings with U-net Sequence-to-Sequence Prediction

Visual landmark coding and dynamic coupling with path integration circuits in area 29e of the rodent parahippocampal cortex

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: James Knierim | Authors: Gorkem Secer, Bharath Krishnan, Noah Cowan and James J Knierim | Summary: The brain relies on external landmarks to anchor internal spatial representations. The neural mechanisms underlying this process and the sources of landmark signals remain […]


Continue.. Visual landmark coding and dynamic coupling with path integration circuits in area 29e of the rodent parahippocampal cortex

A disrupted compartment boundary underlies abnormal cardiac patterning and congenital heart defects

Kavli Affiliate: Denis Wirtz | Authors: Irfan S Kathiriya, Martin H Dominguez, Kavitha S Rao, Jonathon M. Muncie-Vasic, W. Patrick Devine, Kevin M. Hu, Swetansu K Hota, Bayardo I Garay, Diego Quintero, Piyush Goyal, Megan N Matthews, Reuben Thomas, Tatyana Sukonnik, Dario Miguel-Perez, Sarah Winchester, Emily F Brower, AndrĂ© Forjaz, Pei-Hsun Wu, Denis Wirtz, Ashley […]


Continue.. A disrupted compartment boundary underlies abnormal cardiac patterning and congenital heart defects

SLAy-ing oversplitting errors in high-density electrophysiology spike sorting

Kavli Affiliate: Adam S. Charles and Kathleen Cullen | Authors: Sai Koukuntla, Tate DeWeese, Alexandra Cheng, Robyn Mildren, Aamna Lawrence, Austin R Graves, Kathleen E Cullen, Jennifer Colonell, Timothy D Harris and Adam S Charles | Summary: The growing channel count of silicon probes has substantially increased the number of neurons recorded in electrophysiology (ephys) […]


Continue.. SLAy-ing oversplitting errors in high-density electrophysiology spike sorting

Impact of Alzheimer’s disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus

Kavli Affiliate: Keri Martinowich | Authors: Bernard Mulvey, Heena R Divecha, Madhavi Tippani, Svitlana V Bach, Rahul Bharadwaj, Ishbel Del Rosario, Sarah E Maguire, Ryan A Miller, Aaron J Salisbury, Atharv Chandra, Beau A Oster, Kelsey D Montgomery, Sang Ho Kwon, Haya A Algrain, Alexis R Papariello, Louise A Huuki-Myers, Joel E Kleinman, Leonardo Collado-Torres, […]


Continue.. Impact of Alzheimer’s disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus

CRISPR-mediated transcriptional activation as a mutation-independent therapeutic strategy for SYNGAP1-related intellectual disability

Kavli Affiliate: Richard Huganir | Authors: Laura Sichlinger, Molly Reilly, Sakshi Arora, Shuo Zhang, Nicolas Marotta, Kiara L. Rodriguez-Acevedo, Marisol Hooks, Kyle S. Czarnecki, Julia J. Winter, Elisa A. Waxman, Lea V. Dungan, Ingie Hong, Yoichi Araki, Richard Johnson, Richard L. Huganir, Giulia Pavani, Deborah L. French, Beverly L. Davidson, Benjamin L. Prosser and Elizabeth […]


Continue.. CRISPR-mediated transcriptional activation as a mutation-independent therapeutic strategy for SYNGAP1-related intellectual disability