Mobius Assembly for Plant Systems uncovers combinatorial interactions among promoters, coding sequences, and terminators in gene regulation

Posted by dbos Hopkins

Kavli Affiliate: Andreas Andreou | Authors: Elif Gediz Kocaoglan, Andreas Andreou, Jessica Nirkko, Marisol Ochoa-Villarreal, Gary Loake and Naomi Nakayama | Summary: Plants are the primary biological platforms for producing food, energy, and materials in agriculture; however, they are largely untouched by synthetic biology-driven transformation in bioproduction technologies. Molecular tools for complex, multigene engineering are […]


Continue.. Mobius Assembly for Plant Systems uncovers combinatorial interactions among promoters, coding sequences, and terminators in gene regulation

Bridging model and experiment in systems neuroscience with Cleo: the Closed-Loop, Electrophysiology, and Optophysiology simulation testbed

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Kavli Affiliate: Adam S. Charles | Authors: Kyle A. Johnsen, Nathanael A. Cruzado, Zachary C. Menard, Adam A. Willats, Adam S. Charles, Jeffrey E. Markowitz and Christopher J. Rozell | Summary: Systems neuroscience has experienced an explosion of new tools for reading and writing neural activity, enabling exciting new experiments such as all-optical or closed-loop […]


Continue.. Bridging model and experiment in systems neuroscience with Cleo: the Closed-Loop, Electrophysiology, and Optophysiology simulation testbed

qMAP Enabled Microanatomical Mapping of Human Skin Aging

Posted by dbos Hopkins, Yale

Kavli Affiliate: Denis Wirtz | Authors: CKyu Sang Han, Inbal B Sander, Jacqueline Kumer, Eric Preston Resnick, Clare Booth, Yebin Im, Guoqing Cheng, Bartholomew Starich, Ashley L Kiemen, Jude M Phillip, Sashank Reddy, Corrine Joshu, Joel Sunshine, Jeremy Walston, Denis Wirtz and Pei-Hsun Wu | Summary: Aging is a major driver of diseases in humans. […]


Continue.. qMAP Enabled Microanatomical Mapping of Human Skin Aging

Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

Posted by dbos Hopkins, Yale

Kavli Affiliate: Kathleen Cullen | Authors: Arnaud P. J. Giese, Wei-Hsiang Weng, Katie S Kindt, Vanessa H. H. Chang, Jonathan S Montgomery, Evan M. Ratzan, Alisha J. Beirl, Roberto Aponte Rivera, Jeffrey M. Lotthammer, Sanket Walujkar, Mark P. Foster, Omid A. Zobeiri, Jeffrey R. Holt, Saima Riazuddin, Kathleen E. Cullen, Marcos Sotomayor and Zubair M […]


Continue.. Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

Substrate stiffness modulates the emergence and magnitude of senescence phenotypes in dermal fibroblasts

Posted by dbos Hopkins, Yale

Kavli Affiliate: Denis Wirtz | Authors: Bartholomew Starich, Fan Yang, Derin Tanrioven, Heng-Chung Kung, Joanne Baek, Praful R. Nair, Pratik Kamat, Nico Macaluso, Joon Eoh, Kyu Sang Han, Luo Gu, Jeremey Walston, Sean Sun, Pei-Hsun Wu, Denis Wirtz and Jude M. Phillip | Summary: Cellular senescence is a major driver of aging and disease. Here […]


Continue.. Substrate stiffness modulates the emergence and magnitude of senescence phenotypes in dermal fibroblasts

Multi-sample non-negative spatial factorization

Posted by dbos Hopkins

Kavli Affiliate: Loyal Goff | Authors: Multi-sample non-negative spatial factorization | Summary: It is important to model biological variation when analyzing spatial transcriptomics data from multiple samples. One approach to multi-sample analysis is to spatially align samples, but this is a challenging problem. Here, we provide an alignment-free framework for generalizing a one-sample spatial factorization […]


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Comparing Automated Subcortical Volume Estimation Methods; Amygdala Volumes Estimated by FSL and FreeSurfer Have Poor Consistency

Posted by dbos Hopkins

Kavli Affiliate: Martin Lindquist | Authors: Patrick Sadil and Martin A Lindquist | Summary: Subcortical volumes are a promising source of biomarkers and features in biosignatures, and automated methods facilitate extracting them in large, phenotypically rich datasets. However, while extensive research has verified that the automated methods produce volumes that are similar to those generated […]


Continue.. Comparing Automated Subcortical Volume Estimation Methods; Amygdala Volumes Estimated by FSL and FreeSurfer Have Poor Consistency

Neuropathologically-directed profiling of PRNP somatic and germline variants in sporadic human prion disease

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Kavli Affiliate: Michael Miller | Authors: Gannon A. McDonough, Yuchen Cheng, Katherine Morillo, Ryan N. Doan, Connor J. Kenny, Aaron Foutz, Chae Kim, Mark L. Cohen, Brian S. Appleby, Christopher A. Walsh, Jiri G. Safar, August Yue Huang and Michael B. Miller | Summary: Creutzfeldt-Jakob Disease (CJD), the most common human prion disease, is associated […]


Continue.. Neuropathologically-directed profiling of PRNP somatic and germline variants in sporadic human prion disease

Senescent cell heterogeneity and responses to senolytic treatment are related to cell cycle status during cell growth arrest.

Posted by dbos Hopkins

Kavli Affiliate: Denis Wirtz | Authors: Francesco Neri, Shuyuan Zheng, Mark Watson, Pierre Yves Desprez, Akos Gerencser, Judith Campisi, Denis Wirtz, Pei-Hsun Wu and Birgit Schilling | Summary: Cellular senescence has been strongly linked to aging and age-related diseases. It is well established that the phenotype of senescent cells is highly heterogeneous and influenced by […]


Continue.. Senescent cell heterogeneity and responses to senolytic treatment are related to cell cycle status during cell growth arrest.

A multimodal fMRI dataset unifying naturalistic processes with a rich array of experimental tasks

Posted by dbos Hopkins

Kavli Affiliate: Martin Lindquist | Authors: Heejung Jung, Maryam Amini, Bethany J Hunt, Eilis I Murphy, Patrick Sadil, Yaroslav O Halchenko, Bogdan Petre, Zizhuang Miao, Philip A Kragel, Xiaochun Han, Mickela O Heilicher, Michael Sun, Owen G Collins, Martin A Lindquist and Tor D Wager | Summary: Cognitive neuroscience has advanced significantly due to the […]


Continue.. A multimodal fMRI dataset unifying naturalistic processes with a rich array of experimental tasks