Sparse-Coding Variational Auto-Encoders

Kavli Affiliate: Adam S. Charles | Authors: Victor Geadah, G. Barello, Adam Charles and Jonathan Pillow | Summary: The sparse coding model posits that the visual system has evolved to efficiently code natural stimuli using a sparse set of features from an overcomplete dictionary. The original sparse coding model suffered from two key limitations, however: […]


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Pavlovian cue-evoked alcohol seeking is disrupted by ventral pallidal inhibition

Kavli Affiliate: Damon Clark | Authors: Patricia Janak | Summary: Cues paired with alcohol can be potent drivers of craving, alcohol-seeking, consumption, and relapse. While the ventral pallidum is implicated in appetitive and consummatory responses across several reward classes and types of behaviors, its role in behavioral responses to Pavlovian alcohol cues has not previously […]


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Cervical collagen network porosity assessed by SHG endomicroscopy distinguishes preterm and normal pregnancy – a pilot study

Kavli Affiliate: Xingde Li | Authors: Wenxuan Liang, Yuehan Liu, Honghua Guan, Vorada Sakulsaengprapha, Katherine Luby-Phelps, Mala Mahendroo and Xingde Li | Summary: Background Preterm birth (PTB) is a global public health issue affecting millions of newborns every year. Orchestrated remodeling of the cervix is essential for normal pregnancy and birth, while PTB is closely […]


Continue.. Cervical collagen network porosity assessed by SHG endomicroscopy distinguishes preterm and normal pregnancy – a pilot study

An Amygdalar Oscillator Coordinates Cellular and Behavioral Rhythms

Kavli Affiliate: Seth Blackshaw | Authors: Qiang Liu, Jiali Xiong, Dong Won Kim, Sang Soo Lee, Benjamin J. Bell, Chloe Alexandre, Seth Blackshaw, Alban Latremoliere and Mark N. Wu | Summary: Circadian rhythms are generated by the master pacemaker suprachiasmatic nucleus (SCN), in concert with local clocks throughout the body. While many brain regions exhibit […]


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Modulation of GABAA receptor trafficking by WWC2 reveals class-specific mechanisms of synapse regulation by WWC family proteins

Kavli Affiliate: Richard Huganir | Authors: Thomas L Dunham, Julia R Wilkerson, Richard C Johnson, Richard L. Huganir and Lenora J Volk | Summary: WWC2 (WW and C2 domain-containing protein) is implicated in several neurological disorders, however its function in the brain has yet to be determined. Here, we demonstrate that WWC2 interacts with inhibitory […]


Continue.. Modulation of GABAA receptor trafficking by WWC2 reveals class-specific mechanisms of synapse regulation by WWC family proteins

Gene count normalization in single-cell imaging-based spatially resolved transcriptomics

Kavli Affiliate: Jean Fan | Authors: Lyla Atta, Kalen Clifton, Manjari Anant and Jean Fan | Summary: Recent advances in imaging-based spatially resolved transcriptomics (im-SRT) technologies now enable high-throughput profiling of targeted genes and their locations in fixed tissues. Normalization of gene expression data is often needed to account for technical factors that may confound […]


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Next Generation Neuropeptide Y Receptor Small Molecule Agonists Inhibit Mosquito Biting Behavior

Kavli Affiliate: Leslie B. Vosshall and Michael Miller | Authors: Emely V. Zeledon, Leigh A. Baxt, Tanweer A. Khan, Mayako Michino, Michael Miller, David J. Huggins, Caroline S. Jiang, Leslie B. Vosshall and Laura B. Duvall | Summary: Female Aedes aegypti mosquitoes can spread disease-causing pathogens when they bite humans to obtain blood nutrients required […]


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A disrupted compartment boundary underlies abnormal cardiac patterning and congenital heart defects

Kavli Affiliate: Denis Wirtz | Authors: Irfan S Kathiriya, Martin H Dominguez, Kavitha S Rao, Jonathon M. Muncie-Vasic, W. Patrick Devine, Kevin M. Hu, Swetansu K Hota, Bayardo I Garay, Diego Quintero, Piyush Goyal, Megan N Matthews, Reuben Thomas, Tatyana Sukonnik, Dario Miguel-Perez, Sarah Winchester, Emily F Brower, André Forjaz, Pei-Hsun Wu, Denis Wirtz, Ashley […]


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MarmoPose: A Deep Learning-Based System for Real-time Multi-Marmoset 3D Pose Tracking

Kavli Affiliate: Xiaoqin Wang | Authors: Chaoqun Cheng, Zijian Huang, Ruiming Zhang, Guozheng Huang, Han Wang, Likai Tang and Xiaoqin Wang | Summary: The common marmoset has become an important experimental animal model in scientific research. The ability to capture and quantify behaviors of marmosets in natural environment and social scenarios is highly desired by […]


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Solving the where problem in neuroanatomy: a generative framework with learned mappings to register multimodal, incomplete data into a reference brain

Kavli Affiliate: Michael Miller | Authors: Daniel Jacob Tward, Bryson D P Gray, Xu Li, Bingxing Huo, Samik Banerjee, Stephen Savoia, Christopher Mezias, Sukhendu Das, Michael Miller and Partha Pratim Mitra | Summary: A current focus of research in neuroscience is to enumerate, map and annotate neuronal cell types in whole vertebrate brains using different […]


Continue.. Solving the where problem in neuroanatomy: a generative framework with learned mappings to register multimodal, incomplete data into a reference brain