Kavli Affiliate: James Knierim | Authors: Gorkem Secer, James J. Knierim and Noah J. Cowan | Summary: Representations of continuous variables are crucial to create internal models of the external world. A prevailing model of how the brain maintains these representations is given by continuous bump attractor networks (CBANs) in a broad range of brain […]
Kavli Affiliate: Daeyeol Lee and Patricia Janak | Authors: Yifeng Cheng, Robin Magnard, Angela Langdon, Daeyeol Lee and Patricia H. Janak | Summary: Value-based decision-making relies on the striatum, where neural plasticity can be altered by chronic ethanol (EtOH) exposure, but the effects of such plasticity on striatal neural dynamics during decision-making remain unclear. This […]
Kavli Affiliate: Adam S. Charles | Authors: Victor Geadah, G. Barello, Adam Charles and Jonathan Pillow | Summary: The sparse coding model posits that the visual system has evolved to efficiently code natural stimuli using a sparse set of features from an overcomplete dictionary. The original sparse coding model suffered from two key limitations, however: […]
Kavli Affiliate: Damon Clark | Authors: Patricia Janak | Summary: Cues paired with alcohol can be potent drivers of craving, alcohol-seeking, consumption, and relapse. While the ventral pallidum is implicated in appetitive and consummatory responses across several reward classes and types of behaviors, its role in behavioral responses to Pavlovian alcohol cues has not previously […]
Kavli Affiliate: Xingde Li | Authors: Wenxuan Liang, Yuehan Liu, Honghua Guan, Vorada Sakulsaengprapha, Katherine Luby-Phelps, Mala Mahendroo and Xingde Li | Summary: Background Preterm birth (PTB) is a global public health issue affecting millions of newborns every year. Orchestrated remodeling of the cervix is essential for normal pregnancy and birth, while PTB is closely […]
Kavli Affiliate: Seth Blackshaw | Authors: Qiang Liu, Jiali Xiong, Dong Won Kim, Sang Soo Lee, Benjamin J. Bell, Chloe Alexandre, Seth Blackshaw, Alban Latremoliere and Mark N. Wu | Summary: Circadian rhythms are generated by the master pacemaker suprachiasmatic nucleus (SCN), in concert with local clocks throughout the body. While many brain regions exhibit […]
Kavli Affiliate: Richard Huganir | Authors: Thomas L Dunham, Julia R Wilkerson, Richard C Johnson, Richard L. Huganir and Lenora J Volk | Summary: WWC2 (WW and C2 domain-containing protein) is implicated in several neurological disorders, however its function in the brain has yet to be determined. Here, we demonstrate that WWC2 interacts with inhibitory […]
Kavli Affiliate: Jean Fan | Authors: Lyla Atta, Kalen Clifton, Manjari Anant and Jean Fan | Summary: Recent advances in imaging-based spatially resolved transcriptomics (im-SRT) technologies now enable high-throughput profiling of targeted genes and their locations in fixed tissues. Normalization of gene expression data is often needed to account for technical factors that may confound […]
Kavli Affiliate: Leslie B. Vosshall and Michael Miller | Authors: Emely V. Zeledon, Leigh A. Baxt, Tanweer A. Khan, Mayako Michino, Michael Miller, David J. Huggins, Caroline S. Jiang, Leslie B. Vosshall and Laura B. Duvall | Summary: Female Aedes aegypti mosquitoes can spread disease-causing pathogens when they bite humans to obtain blood nutrients required […]
Kavli Affiliate: Denis Wirtz | Authors: Irfan S Kathiriya, Martin H Dominguez, Kavitha S Rao, Jonathon M. Muncie-Vasic, W. Patrick Devine, Kevin M. Hu, Swetansu K Hota, Bayardo I Garay, Diego Quintero, Piyush Goyal, Megan N Matthews, Reuben Thomas, Tatyana Sukonnik, Dario Miguel-Perez, Sarah Winchester, Emily F Brower, André Forjaz, Pei-Hsun Wu, Denis Wirtz, Ashley […]