Kavli Affiliate: Scott Small | Authors: Gabrielle C. Coffing, Silas Tittes, Scott T. Small, Jeremea O. Songco-Casey, Denise M. Piscopo, Judit R. Pungor, Adam C Miller, Cristopher Niell and Andrew D. Kern | Summary: Sex chromosomes are critical elements of sexual reproduction in many animal and plant taxa, however they show incredible diversity and rapid […]

Kavli Affiliate: Franck Polleux Attila Losonczy | Authors: Justin K. O’Hare, Jamie Wang, Margjele D. Shala, Franck Polleux and Attila Losonczy | Summary: Hippocampal pyramidal neurons support episodic memory by integrating complementary information streams into new ‘place fields’. Distal tuft dendrites are thought to initiate place field formation via plateau potentials. However, the hitherto experimental […]

Kavli Affiliate: Liam Paninski | Authors: Ankit Vishnubhotla, Charlotte Loh, Liam Paninski, Akash Srivastava and Cole Lincoln Hurwitz | Summary: Contrastive learning is quickly becoming an essential tool in neuroscience for extracting robust and meaningful representations of neural activity. Despite numerous applications to neuronal population data, there has been little exploration of how these methods […]

Kavli Affiliate: Franck Polleux | Authors: Yusuke Hirabayashi, Tommy L Lewis, Jr., Yudan Du, Daniel M Virga, Aubrianna Decker, Giovanna Coceano, Jonatan Alvelid, Maela Paul, Stevie Hamilton, Parker Kneis, Yasufumi Takahashi, Jellert Gaublomme, Ilaria Testa and Franck Polleux | Summary: In neurons of the mammalian central nervous system (CNS), axonal mitochondria are thought to be […]

Kavli Affiliate: Attila Losonczy | Authors: Zhenrui Liao, Kevin Christian Gonzalez, Deborah Li, Catalina Yang, Donald Holder, Natalie McClain, Guofeng Zhang, Stephen Evans, Maria Chavarha, Jane Yi, Christopher Makinson, Michael Lin, Attila Losonczy and Adrian Negrean | Summary: Fast electrical signaling in dendrites is central to neural computations that support adaptive behaviors. Conventional techniques lack […]

Kavli Affiliate: Liam Paninski Mark Churchland | Authors: Andrew J Zimnik, K. Cora Ames, Xinyue An, Laura Driscoll, Antonio H Lara, Abigail A Russo, Vladislav Susoy, John P Cunningham, Liam Paninski, Mark M Churchland and Joshua I Glaser | Summary: In many neural populations, the computationally relevant signals are posited to be a set of […]

Kavli Affiliate: Michael Shadlen | Authors: Shinichiro Kira, Ariel Zylberberg and Michael N Shadlen | Summary: Abstract Many decisions benefit from the accumulation of evidence obtained sequentially over time. In such circumstances, the decision maker must balance speed against accuracy, and the nature of this tradeoff mediates competing desiderata and costs, especially those associated with […]

Kavli Affiliate: Rafael Yuste | Authors: Netanel Ofer, Victor Hugo Cornejo and Rafael Yuste | Summary: Abstract The propagation of action potentials along axons is traditionally considered to be reliable, as a consequence of the high safety factor of action potential propagation. However, numerical simulations have suggested that, at high frequencies, spikes could fail to […]

Kavli Affiliate: Rafael Yuste | Authors: Nicola Masala, Manuel Mittag, Eleonora Ambrad Giovannetti, Darik A O’Neil, Fabian J Distler, Peter Rupprecht, Fritjof Helmchen, Rafael Yuste, Martin Fuhrmann, Heinz Beck, Michael Wenzel and Tony Kelly | Summary: Abstract Genetically encoded calcium indicators (GECIs) such as GCaMP are invaluable tools in neuroscience to monitor neuronal activity using […]

Kavli Affiliate: Darcy Peterka | Authors: Robert M. Lees, Isaac H. Bianco, Robert A. A. Campbell, Natalia Orlova, Darcy S. Peterka, Bruno Pichler, Spencer LaVere Smith, Dimitri Yatsenko, Che-Hang Yu and Adam M. Packer | Summary: Abstract The goal of this protocol is to enable better characterisation of multiphoton microscopy hardware across a large user […]