Common rules underlying optogenetic and behavioral modulation of responses in multi-cell-type V1 circuits

Kavli Affiliate: Kenneth Miller | Authors: Agostina Palmigiano, Francesco Fumarola, Daniel P. Mossing, Nataliya Kraynyukova, Hillel Adesnik and Kenneth Miller | Summary: The visual cortex receives non-sensory inputs containing behavioral and brain state information. Here we propose a parallel between optogenetic and behavioral modulations of activity and characterize their impact on cell-type-specific V1 processing under […]


Continue.. Common rules underlying optogenetic and behavioral modulation of responses in multi-cell-type V1 circuits

Hippocampal area CA2 controls seizure dynamics, interictal EEG abnormalities and social comorbidity in mouse models of temporal lobe epilepsy

Kavli Affiliate: Steven Siegelbaum | Authors: Christos Panagiotis Lisgaras, Azahara Oliva, Sam Mckenzie, John LaFrancois, Steven A. Siegelbaum and Helen E. Scharman | Summary: Temporal lobe epilepsy (TLE) is characterized by spontaneous recurrent seizures, abnormal activity between seizures, and impaired behavior. CA2 pyramidal neurons (PNs) are potentially important because inhibiting them with a chemogenetic approach […]


Continue.. Hippocampal area CA2 controls seizure dynamics, interictal EEG abnormalities and social comorbidity in mouse models of temporal lobe epilepsy

Adult born hippocampal granule cells promote pattern separation by bidirectionally modulating the remapping of place and cue cells

Kavli Affiliate: Rene Hen | Authors: Sebnem N. Tuncdemir, Andres D. Grosmark, Hannah Chung, Victor M. Luna, Clay O. Lacefield, Attila Losonczy and Rene Hen | Summary: Abstract The hippocampal dentate gyrus (DG) exhibits a unique form of neural plasticity that results from continuous integration of adult born neurons, referred to as ‘adult neurogenesis’. Recent […]


Continue.. Adult born hippocampal granule cells promote pattern separation by bidirectionally modulating the remapping of place and cue cells

Engineered retrovirus-like Arc extracellular vesicles for the in vivo targeted delivery of mRNA into the brain

Kavli Affiliate: Robert Hawkins | Authors: Wenchao Gu, Sijin Luozhong, Ketaki Londhe, Nadine Elkasri, Simian Cai, Robert Hawkins, Zhefan Yuan, Kai Su-Greene, Margaret Cruz, Yu-Wei Chang, Patrick McMullen, Chunyan Wu, Changwoo Seo, Akash Guru, Wenting Gao, Tara Sarmiento, Chris Schaffer, Nozomi Nishimura, Richard Cerione, Melissa Warden, Robert Langer and Shaoyi Jiang | Summary: Abstract Systemic […]


Continue.. Engineered retrovirus-like Arc extracellular vesicles for the in vivo targeted delivery of mRNA into the brain

Direct Cortical Inputs to Hippocampal Area CA1 Transmit Complementary Signals for Goal-directed Navigation

Kavli Affiliate: Attila Losonczy | Authors: John C Bowler and Attila Losonczy | Summary: Summary The entorhinal cortex (EC) is central to the brain’s navigation system. Its subregions are conventionally thought to compute dichotomous representations for spatial processing: medial entorhinal cortex (MEC) provides a global spatial map, while lateral entorhinal cortex (LEC) encodes specific sensory […]


Continue.. Direct Cortical Inputs to Hippocampal Area CA1 Transmit Complementary Signals for Goal-directed Navigation

The HCN1 hyperpolarization-activated cyclic nucleotide-gated channel enhances evoked GABA release from parvalbumin positive interneurons

Kavli Affiliate: Steven Siegelbaum | Authors: Tobias Bock, Eric W Buss, Olivia M Lofaro, Felix W Leroy, Bina Santoro and Steven A Siegelbaum | Summary: Abstract Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels generate the cationic Ih current in neurons and regulate the excitability of neuronal networks. The function of HCN channels depends, in part, on their […]


Continue.. The HCN1 hyperpolarization-activated cyclic nucleotide-gated channel enhances evoked GABA release from parvalbumin positive interneurons

Reduced cholecystokinin-expressing interneuron input contributes to disinhibition of the hippocampal CA2 region in a mouse model of temporal lobe epilepsy

Kavli Affiliate: Steven Siegelbaum | Authors: Alexander C Whitebirch, Anastasia Barnett, Bina Santoro, Helen E Scharfman and Steven A Siegelbaum | Summary: ABSTRACT A significant proportion of temporal lobe epilepsy (TLE) patients experience drug-resistant seizures associated with mesial temporal sclerosis, in which there is extensive cell loss in the hippocampal CA1 and CA3 subfields, with […]


Continue.. Reduced cholecystokinin-expressing interneuron input contributes to disinhibition of the hippocampal CA2 region in a mouse model of temporal lobe epilepsy

An inhibitory plasticity mechanism for world structure inference by hippocampal replay

Kavli Affiliate: Attila Losonczy | Authors: Zhenrui Liao, Darian Hadjiabadi, Satoshi Terada, Ivan Soltesz and Attila Losonczy | Summary: Summary Memory consolidation assimilates recent experiences into long-term memory. This process requires the replay of learned sequences, though the content of these sequences remains controversial. Recent work has shown that the statistics of replay deviate from […]


Continue.. An inhibitory plasticity mechanism for world structure inference by hippocampal replay

A Biophysical Basis for Learning and Transmitting Sensory Predictions

Kavli Affiliate: Larry Abbott, Nathaniel Sawtell | Authors: Salomon Zev Muller, Larry F Abbott and Nathaniel B Sawtell | Summary: Abstract Homeostatic (anti-Hebbian) forms of synaptic are effective at eliminating “prediction errors” that signal the differences between predicted and actual sensory input. However, such mechanisms appear to preclude the possibility of transmitting the resulting predictions […]


Continue.. A Biophysical Basis for Learning and Transmitting Sensory Predictions

Neural representational geometry correlates with behavioral differences between monkeys

Kavli Affiliate: Stefano Fusi | Authors: Valeria Fascianelli, Fabio Stefanini, Satoshi Tsujimoto, Aldo Genovesio and Stefano Fusi | Summary: Abstract Animals likely use a variety of strategies to solve laboratory tasks. Traditionally, combined analysis of behavioral and neural recording data across subjects employing different strategies may obscure important signals and give confusing results. Hence it […]


Continue.. Neural representational geometry correlates with behavioral differences between monkeys