Kavli Affiliate: Stavros Lomvardas | Authors: Martin Escamilla-del-Arenal, Lauren C Tang, Albana Kodra, Hani J Shayya, Aileen C Ugurbil, Olga Stathi, Abdurrahman Keskin, Adan Horta, Joan M Pulupa, Junqiang Ye, Marko Jovanovic, Stavros Lomvardas and Rachel Duffié | Summary: During the switch from progenitor to differentiated cell, cellular physiology must change to accommodate increased translation […]

Kavli Affiliate: Kenneth Miller | Authors: Yue Kris Wu, Ho Yin Chau, Serena Di Santo and Kenneth D. Miller | Summary: Context profoundly shapes neural responses and behavior. During context-dependent sensory processing, recurrent connections shape the integration of feedforward sensory input and feed-back input from downstream brain regions. How do different cell types, interacting through […]

Kavli Affiliate: Attila Losonczy | Authors: Stephanie A Herrlinger, Bovey Rao, Margaret E Conde Paredes, Anna L Tuttman, Haroon Arain, Erdem Varol, Joseph A Gogos and Attila Losonczy | Summary: Individuals with the 22q11.2 deletion syndrome, one of the strongest genetic risk factors for schizophrenia, demonstrate cognitive impairments, including episodic memory dysfunction. Place cell activity […]

Kavli Affiliate: Vincent Ferrera | Authors: Dong Liu, Xingfeng Shao, Fabian A Munoz Silva, Soroosh Sanatkhani, Ray Lee, Elisa Konofagou, Danny JJ Wang and Vincent P Ferrera | Summary: This study applied diffusion-prepared pseudo-continuous arterial spin labeling (DP-pCASL) to quantify cerebral blood flow (CBF), arterial transit time (ATT), and blood-brain barrier (BBB) water exchange rate […]

Kavli Affiliate: Jean Fan | Authors: Caleb Hallinan, Hyun Joo Ji, Edmund Tsou, Steven L Salzberg and Jean Fan | Summary: The accuracy of spatial gene expression profiles generated by probe-based in situ spatially-resolved transcriptomic technologies depends on the specificity with which probes bind to their intended target gene. Off-target binding, defined as a probe […]

Kavli Affiliate: Michael Goldberg | Authors: Peter McHale, Michael E Goldberg and Aaron R Quinlan | Summary: A longstanding goal in human genetics is to prioritize noncoding loci that, when disrupted, lead to developmental disorders and other Mendelian traits. In pursuit of this goal, multiple metrics have been developed to distinguish neutrally evolving sequences from […]

Kavli Affiliate: Sarah Woolley | Authors: Clementine Bodin, Jasmin C.M. Wong, Shane Windsor and Sarah C. Woolley | Summary: Birds are capable of performing elaborate flight maneuvers in variable environmental conditions. While flight is an adaptable and skilled motor behavior, we know surprisingly little about how birds master this ability. Across species, skilled motor behaviors […]

Kavli Affiliate: Stefano Fusi | Authors: Ramon Nogueira, Saleh Esteki, Stefano Fusi and Roozbeh Kiani | Summary: Adaptive behavior requires inferring latent context and rapidly adjusting decisions in response to changing environmental contingencies. We investigated how reward context is learned, represented, and updated during decision making. We recorded large populations of neurons in lateral prefrontal […]

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Daphna Shohamy, Stefano Fusi, and Daniel Salzman | Authors: Daniel L Kimmel, Kimberly Lauren Stachenfeld, Nikolaus Kriegeskorte, Stefano Fusi, C. Daniel Salzman and Daphna Shohamy | Summary: Abstraction and generalization are essential for flexible decision-making in novel situations. Recent work […]