Impact of Task Similarity and Training Regimes on Cognitive Transfer and Interference

Kavli Affiliate: Stefano Fusi | Authors: Nicholas Menghi, Simone Vigano’, William Jeffrey Johnston, Salma Elnagar, Stefano Fusi and Christian F Doeller | Summary: Learning depends not only on the content of what we learn, but also on how we learn and on how experiences are structured over time. To investigate how task similarity and training […]


Continue.. Impact of Task Similarity and Training Regimes on Cognitive Transfer and Interference

Internal and external contexts drive distinct dynamics in shared action-encoding striatal neurons

Kavli Affiliate: Rui Costa | Authors: Tanya Sippy, Jan L. Klee, Sulekh Fernando-Peiris, Sahil Suresh, Ines Rodrigues-Vaz, Rui M. Costa and Vivek R. Athalye | Summary: Animals can flexibly initiate actions guided by external cues or by internal drive. Disease states often disrupt cue-driven and self-paced actions in distinct ways, underscoring separable neural mechanisms. Such […]


Continue.. Internal and external contexts drive distinct dynamics in shared action-encoding striatal neurons

Endothelial Type I Interferon signaling modulates the vascular response to ischemic brain injury

Kavli Affiliate: Elizabeth Hillman | Authors: Mary Claire Tuohy, Ping-Chang Kuo, Adrian Chelminski, Eti Muharremi, Claudia DeSantis, Aomeng Cui, Alicia Russo, Danny Jamoul, Elizabeth Hillman, John F Crary, Jui-Hung Jimmy Yen and Dritan Agalliu | Summary: Vascular normalization [stabilization of aberrant angiogenesis and restoration of blood-brain barrier (BBB)] is critical for reducing long-term secondary sequelae […]


Continue.. Endothelial Type I Interferon signaling modulates the vascular response to ischemic brain injury

ALM enables contextual decision-making via dynamic reconfiguration of local circuits

Kavli Affiliate: Darcy Peterka and Michael Shadlen | Authors: Jia Shen, Nuttida Rungratsameetaweemana, Prayshita Sharma, Darcy S. Peterka, Herbert Zheng Wu and Michael N. Shadlen | Summary: Cognitive operations often require flexible implementation of stimulus–response contingencies, depending on context. We developed an olfactory task in which mice learned to associate a test odor with a […]


Continue.. ALM enables contextual decision-making via dynamic reconfiguration of local circuits

VesiclePy: A Machine Learning Vesicle Analysis Toolbox for Volume Electron Microscopy

Kavli Affiliate: Rafael Yuste | Authors: Jason Ken Adhinarta, Yutian Fan, Adam Gohain, Michael Lin, Paige Nurkin, Richard Ren, Micaela Roth, Shulin Zhang, Ayal Yakobe, Rafael Yuste and Donglai Wei | Summary: Vesicles are critical components of neurons that package neurotransmitters and neuropeptides for their release, in order to communicate with other neurons and cells. […]


Continue.. VesiclePy: A Machine Learning Vesicle Analysis Toolbox for Volume Electron Microscopy

Motor cortex flexibly deploys a high-dimensional repertoire of subskills

Kavli Affiliate: Michael Shadlen and Mark Churchland | Authors: Elom A Amematsro, Eric M Trautmann, Najja J Marshall, LF Abbott, Michael N Shadlen, Daniel M Wolpert and Mark M Churchland | Summary: control strategies and underlying computations. How the motor system achieves such versatility remains unclear. Using high-density Neuropixels recordings from primary motor cortex (M1) […]


Continue.. Motor cortex flexibly deploys a high-dimensional repertoire of subskills

Rare mutations implicate CGE interneurons as a vulnerable axis of cognitive deficits across psychiatric disorders

Kavli Affiliate: Attila Losonczy | Authors: Stephanie A Herrlinger, Jiayao Wang, Bovey Y Rao, Jonathan Chang, Joseph Gogos, Attila Losonczy and Dennis Vitkup | Summary: Neuropsychiatric disorders such as autism spectrum disorder (ASD) and schizophrenia (SCZ) share genetic risk factors, including rare high penetrance single nucleotide variants and copy number variants (CNVs), and exhibit both […]


Continue.. Rare mutations implicate CGE interneurons as a vulnerable axis of cognitive deficits across psychiatric disorders

2P-NucTag: on-demand phototagging for molecular analysis of functionally identified cortical neurons

Kavli Affiliate: Attila Losonczy | Authors: Jingcheng Shi, Boaz Nutkovich, Dahlia Kushinsky, Bovey Y Rao, Stephanie A Herrlinger, Tiberiu S Mihaila, Katayun Cohen-Kashi Malina, Cliodhna K OToole, Margaret E Conde Paredes, Hyun C Yong, Erdem Varol, Attila Losonczy and Ivo Spiegel | Summary: Neural circuits are characterized by genetically and functionally diverse cell types. A […]


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Accessible, realistic genome simulation with selection using stdpopsim

Kavli Affiliate: Scott Small | Authors: Graham Gower, Nathaniel S. Pope, Murillo F. Rodrigues, Silas Tittes, Linh N. Tran, Ornob Alam, Maria Izabel Alves Cavassim, Peter D. Fields, Benjamin C. Haller, Xin Huang, Ben Jeffrey, Kevin Korfmann, Christopher C. Kyriazis, Jiseon Min, Ines Rebollo, Clara T Rehmann, Scott T. Small, Christopher C. R. Smith, Georgia […]


Continue.. Accessible, realistic genome simulation with selection using stdpopsim

StCEL-based platform enables detection and sequencing of native sialoglycoRNA

Kavli Affiliate: Wei Min | Authors: Guang-Dong Zeng, Yun-Long Wang, Xu-Hui Chen, Yi Ma, Zhu Zhu, Huan-Lei Liu, Li-Yuan Fan, Hao Nan, Ziwaregul Nur, Min Wei, Xin-Yuan Liu, Li Yi, Jiu-Yu Jin, Yu-Song Cao, Meng-Bo Qiu, Wei-Peng Sun, Yang Bai, Quan-Bo Zhou, Guo-Qing Zhang, Jing-Feng Chen, Jie Shi, Jian Zheng, Yixuan Xie, Peng Li, Xiang-Bo […]


Continue.. StCEL-based platform enables detection and sequencing of native sialoglycoRNA