Kavli Affiliate: Steven Siegelbaum | Authors: Pegah Kassraian, Shivani K. Bigler, Diana M. Gilly, Neilesh Shrotri and Steven A. Siegelbaum | Summary: The ability to distinguish a threatening from non-threatening conspecific based on past experience is critical for adaptive social behaviors. Although recent progress has been made in identifying the neural circuits that contribute to […]
Kavli Affiliate: Liam Paninski | Authors: Benjamin Antin, Masato Sadahiro, Marta Gajowa, Marcus A. Triplett, Hillel Adesnik and Liam Paninski | Summary: Monosynaptic connectivity mapping is crucial for building circuit-level models of neural computation. Two-photon optogenetic stimulation, when combined with whole-cell recordings, has the potential to map monosynaptic connectivity at an unprecedented scale. However, optogenetic […]
Kavli Affiliate: Rudy Behnia | Authors: Matthias P Christenson, Alvaro Sanz Diez, Sarah L Heath, Maia Saavedra-Weisenhaus, Atsuko Adashi, LF Abbott and Rudy Behnia | Summary: A universal principle of sensory perception is the progressive transformation of sensory information from broad non-specific signals to stimulus-selective signals that form the basis of perception. To perceive color, […]
Kavli Affiliate: Robert Hawkins | Authors: Kerriann K Badal, Abhishek Sadhu, Carrie McCracken, Bindu L Raveendra, Sebastian Lozano-Villada, Amol C Shetty, Phillip Gillette, Yibo Zhao, Dustin Stommes, Lynne A Fieber, Michael C Schmale, Anup Mahurkar, Robert D Hawkins and Sathyanarayanan V Puthanveettil | Summary: Molecular mechanisms underlying aging associated impairments in learning and long-term memory […]
Kavli Affiliate: Michael Shadlen | Authors: Anne Löffler, Ariel Zylberberg, Michael N. Shadlen and Daniel M Wolpert | Summary: Deciding how difficult it is going to be to perform a task allows us to choose between tasks, allocate appropriate resources, and predict future performance. To be useful for planning, difficulty judgments should not require completion […]
Kavli Affiliate: Liam Paninski | Authors: Marcus A Triplett, Marta Gajowa, Hillel Adesnik and Liam Paninski | Summary: Two-photon optogenetics has transformed our ability to probe the structure and function of neural circuits. However, achieving precise optogenetic control of neural ensemble activity has remained fundamentally constrained by the problem of off-target stimulation (OTS): the inadvertent […]
Kavli Affiliate: Vincent Ferrera, Daphna Shohamy, Larry Abbott | Authors: Kenneth Kay, Natalie Biderman, Ramin Khajeh, Manuel Beiran, Christopher J Cueva, Daphna Shohamy, Greg Jensen, Xue-Xin Wei, Vincent P Ferrera and L F Abbott | Summary: Relational cognition — the ability to infer relationships that generalize to novel combinations of objects — is fundamental to […]
Kavli Affiliate: Rui Costa | Authors: Zena K Chatila, Archana Yadav, Jason Mares, Xena E Flowers, Taekyung D Yun, Mamunur Rashid, Ryan Talcoff, Zoe Pelly, Ya Zhang, Philip L De Jager, Andrew F Teich, Rui M Costa, Estela Area Gomez, Gabriela J Martins, Roy N Alcalay, Jean Paul Vonsattel, Vilas Menon, Elizabeth M Bradshaw and […]
Kavli Affiliate: Rui Costa | Authors: Vivek Ravindra Athalye, Preeya Khanna, Suraj Gowda, Amy L Orsborn, Rui M Costa and Jose M Carmena | Summary: It has been proposed that the nervous system has the capacity to generate a wide variety of movements because it re-uses some invariant code. Previous work has identified that dynamics […]
Kavli Affiliate: Sarah Woolley | Authors: Erin Mckenzie Wall and Sarah Cushing Woolley | Summary: Communication governs the formation and maintenance of social relationships. The interpretation of communication signals depends not only on the signal’s content, but also on a receiver’s individual experience. Experiences throughout life may interact to affect behavioral plasticity, such that a […]