Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells

Posted by klaurent Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: Cheng Qian, Ying Xin, Cheng Qi, Hui Wang, Bryan C. Dong, Donald Zack, Seth Blackshaw, Samer Hattar, Feng-Quan Zhou and Jiang Qian | Summary: The progressive death of mature neurons often results in neurodegenerative diseases. While the previous studies have mostly focused on identifying intrinsic mechanisms controlling neuronal survival, […]


Continue.. Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells

Growth of Seed Black Holes in Galactic Nuclei

Posted by klaurent Peking

Kavli Affiliate: Rainer Spurzem | First 5 Authors: Rainer Spurzem, Francesco Rizzuto, Manuel Arca Sedda, Albrecht Kamlah, Peter Berczik | Summary: The evolution of dense star clusters is followed by direct high-accuracy N-body simulation. The problem is to first order a gravitational N-body problem, but stars evolve due to astrophysics and the more massive ones […]


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Revise thermal winds of remnant neutron stars in gamma-ray bursts

Posted by klaurent Peking

Kavli Affiliate: Renxin Xu | First 5 Authors: Shuang Du, Tingting Lin, Shujin Hou, Renxin Xu, | Summary: It seems that the wealth of information revealed by the multi-messenger observations of the binary neutron star (NS) merger event, GW170817/GRB 170817A/kilonova AT2017gfo, places irreconcilable constraints to models of the prompt emission of this gamma-ray burst (GRB). […]


Continue.. Revise thermal winds of remnant neutron stars in gamma-ray bursts

Coronal Properties of Low-Accreting AGNs using Swift, XMM-Newton and NuSTAR Observations

Posted by klaurent Peking

Kavli Affiliate: Claudio Ricci | First 5 Authors: Arghajit Jana, Arka Chatterjee, Hsiang-Kuang Chang, Prantik Nandi, Rubinur K. | Summary: We studied the broadband X-ray spectra of {it Swift}/BAT selected low-accreting AGNs using the observations from {it XMM-Newton}, {it Swift}, and {it NuSTAR} in the energy range of $0.5-150$~keV. Our sample consists of 30 AGNs […]


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Generalizable and explainable prediction of potential miRNA-disease associations based on heterogeneous graph learning

Posted by klaurent UCAS

Kavli Affiliate: Yi Zhou | First 5 Authors: Yi Zhou, Meixuan Wu, Chengzhou Ouyang, Min Zhu, | Summary: Biomedical research has revealed the crucial role of miRNAs in the progression of many diseases, and computational prediction methods are increasingly proposed for assisting biological experiments to verify miRNA-disease associations (MDAs). However, the generalizability and explainability are […]


Continue.. Generalizable and explainable prediction of potential miRNA-disease associations based on heterogeneous graph learning

Generalizable prediction of potential miRNA-disease associations based on heterogeneous graph learning

Posted by klaurent UCAS

Kavli Affiliate: Yi Zhou | First 5 Authors: Yi Zhou, Meixuan Wu, Chengzhou Ouyang, Xinyi Wang, Min Zhu | Summary: Biomedical studies have revealed the crucial role of miRNAs in the progression of many diseases, and computational prediction methods are increasingly proposed for assisting biological experiments to verify miRNA-disease associations (MDAs). The generalizability is a […]


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Removing direct photocurrent artifacts in optogenetic connectivity mapping data via constrained matrix factorization

Posted by klaurent Columbia

Kavli Affiliate: Liam Paninski | Authors: Benjamin Antin, Masato Sadahiro, Marta Gajowa, Marcus A. Triplett, Hillel Adesnik and Liam Paninski | Summary: Monosynaptic connectivity mapping is crucial for building circuit-level models of neural computation. Two-photon optogenetic stimulation, when combined with whole-cell recordings, has the potential to map monosynaptic connectivity at an unprecedented scale. However, optogenetic […]


Continue.. Removing direct photocurrent artifacts in optogenetic connectivity mapping data via constrained matrix factorization

Large Language Models as Superpositions of Cultural Perspectives

Posted by klaurent MIT

Kavli Affiliate: Peter Ford | First 5 Authors: Grgur Kovač, Masataka Sawayama, Rémy Portelas, Cédric Colas, Peter Ford Dominey | Summary: Large Language Models (LLMs) are often misleadingly recognized as having a personality or a set of values. We argue that an LLM can be seen as a superposition of perspectives with different values and […]


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Large Language Models as Superpositions of Cultural Perspectives

Posted by klaurent MIT

Kavli Affiliate: Peter Ford | First 5 Authors: Grgur Kovač, Masataka Sawayama, Rémy Portelas, Cédric Colas, Peter Ford Dominey | Summary: Large Language Models (LLMs) are often misleadingly recognized as having a personality or a set of values. We argue that an LLM can be seen as a superposition of perspectives with different values and […]


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Sensitivity Analysis for Unmeasured Confounding in Medical Product Development and Evaluation Using Real World Evidence

Posted by klaurent Berkeley

Kavli Affiliate: Xiang Zhang | First 5 Authors: Peng Ding, Yixin Fang, Doug Faries, Susan Gruber, Hana Lee | Summary: The American Statistical Association Biopharmaceutical Section (ASA BIOP) working group on real-world evidence (RWE) has been making continuous, extended effort towards a goal of supporting and advancing regulatory science with respect to non-interventional, clinical studies […]


Continue.. Sensitivity Analysis for Unmeasured Confounding in Medical Product Development and Evaluation Using Real World Evidence