BDNF and TRiC-inspired Reagents Rescue Cortical Synaptic Deficits in a Mouse Model of Huntington’s Disease

Posted by klaurent UCSD / Salk

Kavli Affiliate: William Mobley | Authors: Yingli Gu, Alexander Pope, Charlene Smith-Geater, Christopher Carmona, Aaron Johnstone, Linda Shi, Xuqiao Chen, Sarai Santos, Claire C Bacon-Brenes, Thomas Shoff, Korbin M Kleczko, Judith Frydman, Leslie M Thompson, William C Mobley and Chengbiao Wu | Summary: Abstract Huntington’s disease (HD) results from a CAG repeat expansion in the […]


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The gate-tunable Josephson diode

Posted by klaurent Delft

Kavli Affiliate: L. P. Kouwenhoven | First 5 Authors: [#item_custom_name[1]], [#item_custom_name[2]], [#item_custom_name[3]], [#item_custom_name[4]], [#item_custom_name[5]] | Summary: Superconducting diodes are a recently-discovered quantum analogueue of classical diodes. The superconducting diode effect relies on the breaking of both time-reversal and inversion symmetry. As a result, the critical current of a superconductor can become dependent on the direction […]


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Ganymede MHD Model: Magnetospheric Context for Juno’s PJ34 Flyby

Posted by klaurent MIT

Kavli Affiliate: George Clark | First 5 Authors: Stefan Duling, Joachim Saur, George Clark, Frederic Allegrini, Thomas Greathouse | Summary: On June 7th, 2021 the Juno spacecraft visited Ganymede and provided the first in situ observations since Galileo’s last flyby in 2000. The measurements obtained along a one-dimensional trajectory can be brought into global context […]


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Logarithmic Duality of the Curvature Perturbation

Posted by klaurent Tokyo

Kavli Affiliate: Misao Sasaki | First 5 Authors: Shi Pi, Misao Sasaki, , , | Summary: We study the comoving curvature perturbation $mathcal{R}$ in the single-field inflation models whose potential can be approximated by a piecewise quadratic potential $V(varphi)$ by using the $delta N$ formalism. We find a general formula for $mathcal{R}(deltavarphi, deltapi)$, consisting of […]


Continue.. Logarithmic Duality of the Curvature Perturbation

Logarithmic Duality of the Curvature Perturbation

Posted by klaurent Tokyo

Kavli Affiliate: Misao Sasaki | First 5 Authors: Shi Pi, Misao Sasaki, , , | Summary: We study the comoving curvature perturbation $mathcal{R}$ in the single-field inflation models whose potential can be approximated by a piecewise quadratic potential $V(varphi)$ by using the $delta N$ formalism. We find a general formula for $mathcal{R}(deltavarphi, deltapi)$, consisting of […]


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Multiplexed and scalable cellular phenotyping toward the standardized three-dimensional human neuroanatomy

Posted by klaurent Rockefeller

Kavli Affiliate: Nathaniel Heintz | Authors: Tatsuya C. Murakami and Nathaniel Heintz | Summary: Abstract The advent of three-dimensional histological methods has advanced studies of cellular-resolution anatomy of the brain. The use of whole-mount staining and tissue clearing has advanced systems-level identification of cells underlying brain functions in mouse models. However, application of these methods […]


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Copiotrophs dominate rhizosphere microbiomes and growth rate potential is a major factor explaining the rhizosphere effect

Posted by klaurent UCSD / Salk

Kavli Affiliate: Jose Suarez Lopez | Authors: José Luis López, Nikolaos Pappas, Sanne WM Poppeliers, Juan J. Sanchez-Gil, Arista Fourie-Fouche, Ronnie de Jonge and Bas E. Dutilh | Summary: Abstract The structure and function of the root microbial community is shaped by plant root activity, enriching specific microbial taxa and functions from the surrounding soil […]


Continue.. Copiotrophs dominate rhizosphere microbiomes and growth rate potential is a major factor explaining the rhizosphere effect

Multiplexed selectivity screening of anti-GPCR antibodies

Posted by klaurent Rockefeller

Kavli Affiliate: Thomas P. Sakmar | Authors: Leo Dahl, Ilana Kotliar, Annika Bendes, Tea Dodig-Crnkovic, Samuel Fromm, Arne Elofsson, Mathias Uhlen, Thomas P Sakmar and Jochen Schwenk | Summary: Abstract G protein-coupled receptors (GPCRs) control critical cellular signaling pathways. Therapeutic agents, such as antibodies (Abs), are being developed to modulate GPCR signaling pathways. However, validating […]


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Disordered topological graphs enhancing nonlinear phenomena

Posted by klaurent Berkeley

Kavli Affiliate: Joel Moore | First 5 Authors: , , , , | Summary: Complex networks play a fundamental role in understanding phenomena from the collective behavior of spins, neural networks, and power grids to the spread of diseases. Topological phenomena in such networks have recently been exploited to preserve the response of systems in […]


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Environmental and genetic drivers of population differences in SARS-CoV-2 immune responses

Posted by klaurent Rockefeller

Kavli Affiliate: Jean Laurent Casanova | Authors: Yann Aquino, Aurélie Bisiaux, Zhi Li, Mary O’Neill, Javier Mendoza-Revilla, Sarah Hélène Merkling, Gaspard Kerner, Milena Hasan, Valentina Libri, Vincent Bondet, Nikaïa Smith, Camille de Cevins, Mickaël M Ménager, Francesca Luca, Roger Pique-Regi, Giovanna Barba-Spaeth, Stefano Pietropaoli, Olivier Schwartz, Geert Leroux-Roels, Cheuk-Kwong Lee, Kathy Leung, Joseph T.K. Wu, […]


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