Partitioning variance in cortical morphometry into genetic, environmental, and subject-specific components using a large adolescent sample

Posted by klaurent UCSD / Salk

Kavli Affiliate: Anders Dale | Authors: Diana M. Smith, Pravesh Parekh, Joseph Kennedy, Robert J. Loughnan, Oleksandr Frei, Thomas E. Nichols, Ole A. Andreassen, Terry L. Jernigan and Anders M. Dale | Summary: The relative contributions of genetic variation and experience in shaping the morphology of the adolescent brain are not fully understood. Using longitudinal […]


Continue.. Partitioning variance in cortical morphometry into genetic, environmental, and subject-specific components using a large adolescent sample

Direct observation of the neural computations underlying a single decision

Posted by klaurent Columbia

Kavli Affiliate: Michael Shadlen | Authors: Natalie A Steinemann, Gabriel M Stine, Eric M Trautmann, Ariel Zylberberg, Daniel M Wolpert and Michael N Shadlen | Summary: Neurobiological investigations of perceptual decision-making have furnished the first glimpse of a flexible cognitive process at the level of single neurons (Shadlen and Newsome, 1996; Shadlen and Kiani, 2013). […]


Continue.. Direct observation of the neural computations underlying a single decision

Bidirectional Regulation of Motor Circuits Using Magnetogenetic Gene Therapy

Posted by klaurent Rockefeller

Kavli Affiliate: Jeffrey M. Friedman | Authors: Santiago R Unda, Roberta Marongiu, Lisa E Pomeranz, Jonathan P Dyke, Edward K Fung, Logan Grosenick, Rick Zirkel, Aldana M Antoniazzi, Sofya Norman, Conor M Liston, Chris B Schaffer, Nozomi Nishimura, Sarah A Stanley, Jeffrey M Friedman and Michael G Kaplitt | Summary: Regulating the activity of discrete […]


Continue.. Bidirectional Regulation of Motor Circuits Using Magnetogenetic Gene Therapy

A recurrent network model of planning explains hippocampal replay and human behavior

Posted by klaurent UCSD / Salk

Kavli Affiliate: Marcelo Mattar | Authors: Kristopher T. Jensen, Guillaume Hennequin and Marcelo G. Mattar | Summary: When interacting with complex environments, humans can rapidly adapt their behavior to changes in task or context. To facilitate this adaptation, we often spend substantial periods of time contemplating possible futures before acting. For such planning to be […]


Continue.. A recurrent network model of planning explains hippocampal replay and human behavior

Widespread Receptive Field Remapping in Early Visual Cortex

Posted by klaurent Yale

Kavli Affiliate: Anirvan Nandy | Authors: Sachira Denagamage, Mitchell P Morton and Anirvan Nandy | Summary: Our eyes are in constant motion, yet we perceive the visual world as being stable. Predictive remapping of receptive fields is thought to be one of the critical mechanisms for enforcing perceptual stability during eye movements. While receptive field […]


Continue.. Widespread Receptive Field Remapping in Early Visual Cortex

Magnetogenetic cell activation using endogenous ferritin

Posted by klaurent Rockefeller

Kavli Affiliate: Jeffrey M. Friedman | Authors: Lisa E Pomeranz, Rosemary Li, Xiaofei A Yu, Leah Kelly, Gholamreza Hassanzadeh, Henrik Molina, Daniel Gross, Matthew I Brier, George Vaisey, Putianqi Wang, Maria Jimenez-Gonzalez, Adolfo Garcia-Ocana, Jonathan Dordick, Jeffrey M. Friedman and Sarah A Stanley | Summary: The ability to precisely control the activity of defined cell […]


Continue.. Magnetogenetic cell activation using endogenous ferritin

The representational geometry of emotional states in basolateral amygdala

Posted by klaurent Columbia

Kavli Affiliate: Stefano Fusi, Daniel Salzman | Authors: Pia-Kelsey O’Neill, Lorenzo Posani, Jozsef Meszaros, Phebe Warren, Carl E. Schoonover, Andrew J.P. Fink, Stefano Fusi and C. Daniel Salzman | Summary: Sensory stimuli associated with aversive outcomes can cause multiple behavioral responses related to an animal’s evolving emotional state. We employed chemogenetic inactivation and two-photon imaging […]


Continue.. The representational geometry of emotional states in basolateral amygdala

Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis

Posted by klaurent Hopkins

Kavli Affiliate: Denis Wirtz | Authors: Devon E Mason, Megan Goeckel, Sebastian L Vega, Pei-Hsun Wu, Dymonn Johnson, Su-Jin Heo, Denis Wirtz, Jason A Burdick, Levi Wood, Brain Y Chow, Amber N Stratman and Joel D Boerckel | Summary: Vascular morphogenesis requires persistent endothelial cell motility that is responsive to diverse and dynamic mechanical stimuli. […]


Continue.. Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis

Brain substates induced by DMT relate to sympathetic output and meaningfulness of the experience

Posted by klaurent UCSF

Kavli Affiliate: Adam Gazzaley | Authors: Lorenzo Pasquini, Alexander Simon, Courtney Gallen, Hannes Kettner, Leor Roseman, Adam Gazzaley, Robin Carhart-Harris and Christopher Timmermann | Summary: N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic, known to rapidly induce short-lasting alterations in conscious experience, characterized by a profound and immersive sense of physical transcendence alongside rich and vivid auditory […]


Continue.. Brain substates induced by DMT relate to sympathetic output and meaningfulness of the experience

Cellular and Molecular Basis of Leptin Resistance

Posted by klaurent Rockefeller

Kavli Affiliate: Jeffrey M. Friedman | Authors: Bowen Tan, Kristina Hedbacker, Leah Kelly, Zhaoyue Zhang, Ji-Dung Luo, Joshua D. Rabinowitz and Jeffrey M. Friedman | Summary: Obese humans and diet induced obese mice (DIO) have high leptin levels and fail to respond to the exogenous hormone suggesting that obesity is caused by leptin resistance, the […]


Continue.. Cellular and Molecular Basis of Leptin Resistance