Evidence for AGN-Regulated Cooling in Clusters at $z sim 1.4$: A Multi-Wavelength View of SPT-CL J0607-4448

Posted by klaurent Chicago

Kavli Affiliate: Bradford A. Benson | First 5 Authors: Megan Masterson, Michael McDonald, Behzad Ansarinejad, Matthew Bayliss, Bradford A. Benson | Summary: We present a multi-wavelength analysis of the galaxy cluster SPT-CL J0607-4448 (SPT0607), which is one of the most distant clusters discovered by the South Pole Telescope (SPT) at $z=1.4010pm0.0028$. The high-redshift cluster shows […]


Continue.. Evidence for AGN-Regulated Cooling in Clusters at $z sim 1.4$: A Multi-Wavelength View of SPT-CL J0607-4448

Unification of thermal and quantum noise in gravitational-wave detectors

Posted by klaurent MIT

Kavli Affiliate: Lee McCuller | First 5 Authors: Chris Whittle, Lee McCuller, Vivishek Sudhir, Matthew Evans, | Summary: Contemporary gravitational-wave detectors are fundamentally limited by thermal noise — due to dissipation in the mechanical elements of the test mass — and quantum noise — from the vacuum fluctuations of the optical field used to probe […]


Continue.. Unification of thermal and quantum noise in gravitational-wave detectors

Dissipative Optomechanics in High-Frequency Nanomechanical Resonators

Posted by klaurent Delft

Kavli Affiliate: Simon Groblacher | First 5 Authors: André G. Primo, Pedro V. Pinho, Rodrigo Benevides, Simon Gröblacher, Gustavo S. Wiederhecker | Summary: The coherent transduction of information between microwave and optical domains is a fundamental building block for future quantum networks. A promising way to bridge these widely different frequencies is using high-frequency nanomechanical […]


Continue.. Dissipative Optomechanics in High-Frequency Nanomechanical Resonators

Reduced progranulin increases tau and α-synuclein inclusions and alters phenotypes of tauopathy mice via glucocerebrosidase

Posted by klaurent Yale

Kavli Affiliate: Stephen Strittmatter | Authors: Hideyuki Takahashi, Sanaea Bhagwagar, Sarah H. Nies, Marius T. Chiasseu, Guilin Wang, Ian R. Mackenzie and Stephen M. Strittmatter | Summary: Comorbid proteinopathies are observed in many neurodegenerative disorders including Alzheimer’s disease (AD), increase with age, and influence clinical outcomes, yet the mechanisms remain ill-defined. Here, we show that […]


Continue.. Reduced progranulin increases tau and α-synuclein inclusions and alters phenotypes of tauopathy mice via glucocerebrosidase

LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia via Transcription Factor E3 Inhibition

Posted by klaurent Yale

Kavli Affiliate: Shawn Ferguson | Authors: Narayana Yadavalli and Shawn M. Ferguson | Summary: Variants in leucine rich repeat kinase 2 (LRRK2) that increase kinase activity confer risk for sporadic and familial forms of Parkinson’s disease. However, LRRK2-dependent cellular processes responsible for disease risk remain uncertain. Here we show that LRRK2 negatively regulates lysosome degradative […]


Continue.. LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia via Transcription Factor E3 Inhibition

Expression bias in retinoic acid responsive genes defines variations in neural differentiation of human pluripotent stem cells

Posted by klaurent Yale

Kavli Affiliate: Nenad Sestan | Authors: Suel-Kee Kim, Seungmae Seo, Genevieve Stein-O’Brien, Amritha Jaishankar, Kazuya Ogawa, Nicola Micali, Victor Luria, Amir Karger, Yanhong Wang, Thomas M. Hyde, Joel E. Kleinman, Ty Voss, Elana J. Fertig, Joo-Heon Shin, Roland Bürli, Alan J. Cross, Nicholas J. Brandon, Daniel R. Weinberger, Joshua G. Chenoweth, Daniel J. Hoeppner, Nenad […]


Continue.. Expression bias in retinoic acid responsive genes defines variations in neural differentiation of human pluripotent stem cells

Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury

Posted by klaurent UCSF

Kavli Affiliate: David Rowitch | Authors: Patricia Renz, Daniel Surbek, Valérie Haesler, Vera Tscherrig, Eric J Huang, Manideep Chavali, Shane Liddelow, David Rowitch, Andreina Schoeberlein and Amanda Brosius Lutz | Summary: The role of reactive astrocytes in perinatal white matter injury (WMI) is unclear. In a mouse model of WMI, we provide evidence that impairing […]


Continue.. Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury

Multi-center integrated analysis of non-coding CRISPR screens

Posted by klaurent Hopkins

Kavli Affiliate: Michael Beer | Authors: David Yao, Josh Tycko, Woo Oh, Lexi R. Bounds, Sager J. Gosai, Lazaros Lataniotis, Ava Mackay-Smith, Benjamin R. Doughty, Idan Gabdank, Henri Schmidt, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunahi Luo, Keith Siklenka, Galip Gurkan Yardimci, The ENCODE4 Consortium, Ryan Tewhey, Anshul Kundaje, William J. Greenleaf, Pardis […]


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Observation of suppressed viscosity in the normal state of $^3$He due to superfluid fluctuations

Posted by klaurent Cornell

Kavli Affiliate: Jeevak M. Parpia | First 5 Authors: Rakin N. Baten, Yefan Tian, Eric N. Smith, Erich Mueller, Jeevak M. Parpia | Summary: By monitoring the quality factor of a quartz tuning fork oscillator we have observed a fluctuation-driven reduction in the viscosity of bulk $^3$He in the normal state near the superfluid transition […]


Continue.. Observation of suppressed viscosity in the normal state of $^3$He due to superfluid fluctuations

Observation of suppressed viscosity in the normal state of $^3$He due to superfluid fluctuations

Posted by klaurent Cornell

Kavli Affiliate: Jeevak M. Parpia | First 5 Authors: Rakin N. Baten, Yefan Tian, Eric N. Smith, Erich Mueller, Jeevak M. Parpia | Summary: By monitoring the quality factor of a quartz tuning fork oscillator we have observed a fluctuation-driven reduction in the viscosity of bulk $^3$He in the normal state near the superfluid transition […]


Continue.. Observation of suppressed viscosity in the normal state of $^3$He due to superfluid fluctuations