Genome editing of phylogenetically distinct bacteria using portable retron-mediated recombineering

Posted by dbos UCSF

Kavli Affiliate: Seth Shipman | Authors: Alejandro Gonzalez-Delgado, Laura Bonillo-Lopez, Milo S Johnson, Nastassia Knoedlseder, Ching-Chung Ko, Yassir Lekbach, Jee-Hwan Oh, Hemaa Selvakumar, Michael C Wold, Zihan Yu, Virginia Aragon, Jeffrey A Gralnick, Marc Guell, Graham Hatfull, Benjamin Keith Keitz, Britt Koskella, Vivek K Mutalik, Jan Peter van Pijkeren and Seth Shipman | Summary: Advanced […]


Continue.. Genome editing of phylogenetically distinct bacteria using portable retron-mediated recombineering

A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito

Posted by dbos Rockefeller

Kavli Affiliate: Leslie B. Vosshall | Authors: Olivia V. Goldman, Alexandra E. DeFoe, Yanyan Qi, Yaoyu Jiao, Shih-Che Weng, Leah Houri-Zeevi, Priyanka Lakhiani, Takeshi Morita, Jacopo Razzauti, Adriana Rosas-Villegas, Yael N. Tsitohay, Madison M. Walker, Ben R. Hopkins, Mosquito Cell Atlas Consortium, Omar S. Akbari, Laura B. Duvall, Helen White-Cooper, Trevor R. Sorrells, Roshan Sharma, […]


Continue.. A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito

Inhibitory neurons marked by the connectivity molecule Kirrel3 regulate memory precision

Posted by dbos UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Arnulfo B.N. Tunon-Ortiz, Dimitri Trankner, Chandler M. Peterson, Omar Shennib, Fangfei Ye, Jiani Shi, Sarah N. Brockway, Olivia Katherine Raines, Abbey Mahnke, Matthew Grega, Keun-Young Kim, Mark Ellisman, James G. Heys, Moriel Zelikowsky and Megan E Williams | Summary: The homophilic adhesion molecule Kirrel3 drives synapse formation between dentate […]


Continue.. Inhibitory neurons marked by the connectivity molecule Kirrel3 regulate memory precision

Small siphophage binding to an open state of the LptDE outer membrane lipopolysaccharide translocon

Posted by dbos UCSD / Salk

Kavli Affiliate: Robert E. Clark | Authors: Bert van den Berg, Emily Dunbar, Robert Clark, Arnaud Basle, Shenaz Allyjaun, Hector Newman, Julia Hubbard and Syma Khalid | Summary: Bacteriophages are bacterial viruses that provide alternatives to small-molecule drugs to combat infections by antibiotic-resistant bacteria. To infect a bacterial host, a phage needs to bind to […]


Continue.. Small siphophage binding to an open state of the LptDE outer membrane lipopolysaccharide translocon

Electrocorticographic Detection of Speech Networks in Glioma-infiltrated Cortex

Posted by dbos UCSF

Kavli Affiliate: Edward Chang | Authors: Vardhaan S Ambati, Amit S Persad, Jasleen Kaur, Sanjeev Herr, Emily Cunningham, Abraham Dada, Justyna O Ekert, Quinn Greicius, Alexander Silva, Paul McMillan Villalobos, Niels Olshausen, Youssef Sibih, Sena Oten, Hunter S. Yamada, Gray Umbach, Alexander A Aabedi, Wajd Al-Holou, Jacob Young, Madhumita Sushil, Edward F Chang, Mitchel S. […]


Continue.. Electrocorticographic Detection of Speech Networks in Glioma-infiltrated Cortex

Multimodal sensory overload in dopamine-deficient larval zebrafish leads to paradoxical kinesia

Posted by dbos UCSF

Kavli Affiliate: Su Guo | Authors: Krishnashish Bose, Su Guo and Karnika Bhardwaj | Summary: Paradoxical kinesia—the temporary alleviation of motor deficits by powerful, urgent stimuli in Parkinson’s disease (PD)—remains poorly understood at the neural circuit level. Through chemo-genetic ablation of tyrosine hydroxylase-expressing neurons in larval zebrafish and brain-wide calcium imaging under head-fixed, tail-free conditions, […]


Continue.. Multimodal sensory overload in dopamine-deficient larval zebrafish leads to paradoxical kinesia

Ptbp1 is not required for retinal neurogenesis and cell fate specification.

Posted by dbos Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: Haley Appel, Rogger Carmen-Orozco, Clayton Santiago, Thanh Hoang and Seth Blackshaw | Summary: The RNA-binding protein Ptbp1 has been proposed as a master regulator of neuronal fate, repressing neurogenesis through its effects on alternative splicing and miRNA maturation. While prior studies using RNA interference suggested that Ptbp1 loss promotes […]


Continue.. Ptbp1 is not required for retinal neurogenesis and cell fate specification.

Connectome analysis of a cerebellum-like circuit for sensory prediction

Posted by dbos Columbia

Kavli Affiliate: Nathaniel Sawtell | Authors: Krista E Perks, Mariela D Petkova, Salomon Z Muller, Michael Genecin, Adishree Ghatare, Richard Schalek, Yuelong Wu, Michal Januszewski, Viren Jain, Jeff W Lichtman, LF Abbott and Nathaniel B Sawtell | Summary: Transitive inference (TI) is a cognitive process in which decisions are guided by internal representations of abstract […]


Continue.. Connectome analysis of a cerebellum-like circuit for sensory prediction

Universal lower bound on the axion decay constant from free streaming effects

Posted by dbos Chicago

Kavli Affiliate: Wayne Hu | First 5 Authors: Keisuke Harigaya, Wayne Hu, Rayne Liu, Huangyu Xiao, | Summary: We show that enhancement of the axion relic abundance compared to the standard misalignment contribution generically leads to the production of nonzero momentum axion modes, resulting in warm dark matter behavior and enhanced isocurvature perturbations. It leads […]


Continue.. Universal lower bound on the axion decay constant from free streaming effects

Learning decouples accuracy and reaction time for rapid decisions in a transitive inference task

Posted by dbos Columbia

Kavli Affiliate: Vincent Ferrera | Authors: Fabian A Munoz Silva, Greg Jensen, Maxwell Shinn, Yelda Alkan, John Murray, Herbert Terrace and Vincent P Ferrera | Summary: Transitive inference (TI) is a cognitive process in which decisions are guided by internal representations of abstract relationships. While the mechanisms underlying transitive learning have been well studied, the […]


Continue.. Learning decouples accuracy and reaction time for rapid decisions in a transitive inference task