De novo minibinders targeting RH5 achieve nanomolar inhibition of blood-stage malaria replication

Posted by dbos Oxford

Kavli Affiliate: Simon DraperJason Hsiao, Melina Shamshoum, Abhiram Chalamalasetty, Jordan R. Barrett, Ricardo Almada-Monter, Elizabeth Tabornal, Emily Wilks, Yi-Zong Lee, Nathan Beutler, Amanda Richard Lukens, Priyan Kapoor, Daisy Chen, Justice Ndihokubwayo, Barnabas G Williams, Kirsty McHugh, David Pulido, Irina Mendes de Sousa, Elizabeth Komives, Emília V. Noormahomed, Ian A. Wilson, Dyann F. Wirth, Thomas Rogers, […]


Continue.. De novo minibinders targeting RH5 achieve nanomolar inhibition of blood-stage malaria replication

Snurportin-1 maintains muscle niche integrity and myogenic progenitor homeostasis

Posted by dbos NTNU

  Kavli Affiliate: Emre Yaksi | Authors: Hilal Piril Saracoglu, Marwan Nashabat, Duygu Naz Kutlu, Burak Saribas, Elanur Yilmaz, Seymanur Tur, Hulya Kayserili, Emre Yaksi, Nasrin Nabavizadeh and Nathalie Escande-Beillard | Summary: Loss-of-function variants in SNUPN, encoding the nuclear import factor Snurportin-1 (SPN1) required for spliceosomal small nuclear ribonucleoprotein (snRNP) transport, cause a recently described […]


Continue.. Snurportin-1 maintains muscle niche integrity and myogenic progenitor homeostasis

Divergent Dopamine Dynamics within the Accumbens Core

Posted by dbos UCSF

  Kavli Affiliate: Joshua Berke | Authors: Seongtak Kang, Dennis A Burke, Caroline Kornbrek, Farah Farouq, Huijeong Jeong, Vijay Mohan K Namboodiri and Joshua Berke | Summary: Dopamine in the nucleus accumbens Core powerfully influences motivation and learning, yet the information encoded by Core dopamine remains unresolved. Competing theories typically assume a spatially uniform signal, […]


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VLBI Astrometric Procedure and Performance with CHIME/FRB Outriggers

Posted by klaurent MIT

Kavli Affiliate: Kiyoshi Masui | Summary:Precise localizations of fast radio bursts (FRBs) to specific environments within their host galaxies with very-long-baseline interferometry (VLBI) have provided valuable insights into the nature of their progenitors. To date, such localizations have relied primarily on traditional VLBI facilities, whose observational capabilities limit them to targeted follow-up on a small […]


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Two-sample tests for principal eigenvalues and eigenvectors in high-dimensional elliptical factor models

Posted by klaurent Peking

Kavli Affiliate: Feng Long| Summary: Changes in principal eigenvalues and eigendirections provide complementary diagnostics of structural instability in factor models, but covariance-based inference can be unreliable under heavy tails. We develop two-sample tests for equality of these features of trace-normalized shape matrices under high-dimensional elliptical factor models. Our approach combines Tyler’s identity with orthogonalization and […]


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GA-NIFS: sRMS, a new method for disentangling resolved and unresolved emission in integral field spectroscopy. Application to distant quasars

Posted by klaurent Cambridge

Kavli Affiliate: Roberto Maiolino | Summary:The interpretation of AGN emission-line profiles in type1 AGN is often complicated by the dominance of bright, spatially unresolved nuclear continuum and broad-line region (BLR) emission over narrower and blended components from the narrow-line region (NLR) and the host galaxy. This remains challenging even with integral-field spectroscopy (IFS), as the […]


Continue.. GA-NIFS: sRMS, a new method for disentangling resolved and unresolved emission in integral field spectroscopy. Application to distant quasars

GA-NIFS: sRMS, a new method for disentangling resolved and unresolved emission in integral field spectroscopy. Application to distant quasars

Posted by klaurent Cambridge

Kavli Affiliate: Roberto Maiolino | Summary:The interpretation of AGN emission-line profiles in type1 AGN is often complicated by the dominance of bright, spatially unresolved nuclear continuum and broad-line region (BLR) emission over narrower and blended components from the narrow-line region (NLR) and the host galaxy. This remains challenging even with integral-field spectroscopy (IFS), as the […]


Continue.. GA-NIFS: sRMS, a new method for disentangling resolved and unresolved emission in integral field spectroscopy. Application to distant quasars

Astrometric Evidence for Outer Giant Planets in Known Exoplanet Systems

Posted by klaurent Caltech

Kavli Affiliate: Dimitri Mawet| Summary:Outer giant planets can influence the formation and dynamical evolution of their planetary systems. However, their long orbital periods make them difficult to detect using transit and radial velocity (RV) techniques. Measurements from Hipparcos, Gaia DR2 and DR3 (G23H) can detect the stellar reflex motion induced by distant companions before the […]


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Emergent Symmetries in Ensemble Averages

Posted by klaurent Tokyo

Kavli Affiliate: Masahito Yamazaki | Summary:It is widely believed that there are no exact global symmetries in quantum gravity. We review recent works showing that global symmetries can nevertheless emerge after ensemble averages of theories, as encountered in holography. As a precision case study, we discuss the ensemble average of two-dimensional Narain-type conformal field theories […]


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Computing gravitational radiation from highly eccentric bound binaries in the small-mass-ratio limit

Posted by klaurent MIT

Kavli Affiliate: Scott A. Hughes | Summary:Precise strong-gravity models describing the evolution of bound compact binary systems provide important information about the gravitational radiation such binaries generate and how they evolve due to the radiation’s backreaction. The limit of very high eccentricity, $e to 1$, is challenging to model: frequency-domain techniques require many harmonics to […]


Continue.. Computing gravitational radiation from highly eccentric bound binaries in the small-mass-ratio limit