Observation-Specific Uncertainty Modeling for Latent-Variable Regression in High-Dimensional Analytical Data

Kavli Affiliate: Molly Stevens | Summary:Across many fields, including medical diagnostics, process monitoring, and quality control, decisions often rely on point predictions for single samples. Observation-specific uncertainty is needed to assess the risk of decision error when predictions are compared with thresholds. Latent-variable regression is widely used for such predictions, but observation-specific uncertainty remains difficult […]


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De novo minibinders targeting RH5 achieve nanomolar inhibition of blood-stage malaria replication

Kavli Affiliate: Simon DraperJason Hsiao, Melina Shamshoum, Abhiram Chalamalasetty, Jordan R. Barrett, Ricardo Almada-Monter, Elizabeth Tabornal, Emily Wilks, Yi-Zong Lee, Nathan Beutler, Amanda Richard Lukens, Priyan Kapoor, Daisy Chen, Justice Ndihokubwayo, Barnabas G Williams, Kirsty McHugh, David Pulido, Irina Mendes de Sousa, Elizabeth Komives, Emília V. Noormahomed, Ian A. Wilson, Dyann F. Wirth, Thomas Rogers, […]


Continue.. De novo minibinders targeting RH5 achieve nanomolar inhibition of blood-stage malaria replication

Single-molecule imaging of DNA repair and cytoplasmic rigidification in intracellular bacteria

Kavli Affiliate: Lindsay Baker | Authors: Fiona Anne Sargison, Nicolas Cherif Ducrot, Clara Kummerer, Claire Qu, Treasa B O’Hagan, Elliott Haywood, Anju Kudhail, Amy N Moores, Lindsay Baker and Stephan Uphoff | Summary: DNA damage is an important component of the antibacterial response of phagocytes, but which DNA repair mechanisms are active in intracellular bacteria […]


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Population-scale subcellular proteomics reveals intracellular remodelling across the Alzheimer’s disease-resilience spectrum

Kavli Affiliate: Becky Carlyle | Authors: Helen A. Jolly, Paula Seghers, Kaleah Balcomb, Amelia J. Smith, Laura Pearson, Ishan Agrawal, Bethany Geary, David A. Bennett, Thomas Wisniewski, Stephanie L. Fowler, Eleanor Drummond, Oliver M. Crook and Becky C. Carlyle | Summary: Proteome-wide analyses of human tissue have transformed our understanding of disease, but provide limited […]


Continue.. Population-scale subcellular proteomics reveals intracellular remodelling across the Alzheimer’s disease-resilience spectrum

Phase-only control of GRAPE shaped pulses

Kavli Affiliate: Andrew Baldwin | Summary: We compare phase-only control with phase-and-amplitude control when designing shaped pulses using the GRAPE algorithm, and explain why phase-only control has significant advantages. Trotterisation can be used to simulate amplitude modulation with phase modulation, indicating that the two approaches are fundamentally equivalent. Pulses designed by either method can be […]


Continue.. Phase-only control of GRAPE shaped pulses

Phase-only control of GRAPE shaped pulses

Kavli Affiliate: Andrew Baldwin | Summary: We compare phase-only control with phase-and-amplitude control when designing shaped pulses using the GRAPE algorithm, and explain why phase-only control has significant advantages. Trotterisation can be used to simulate amplitude modulation with phase modulation, indicating that the two approaches are fundamentally equivalent. Pulses designed by either method can be […]


Continue.. Phase-only control of GRAPE shaped pulses

Phase-only control of GRAPE shaped pulses

Kavli Affiliate: Andrew Baldwin | Summary: We compare phase-only control with phase-and-amplitude control when designing shaped pulses using the GRAPE algorithm, and explain why phase-only control has significant advantages. Trotterisation can be used to simulate amplitude modulation with phase modulation, indicating that the two approaches are fundamentally equivalent. Pulses designed by either method can be […]


Continue.. Phase-only control of GRAPE shaped pulses

HTRA1 deficiency in COL4A1 mutant hiPSC-derived astrocytes, a convergent mechanism of cerebral small vessel disease

Kavli Affiliate: Zameel Cader | Authors: Xuewei Qi, Alessandra Granata, Tom Van Agtmael, Sanjay Sinha, Zameel Cader, Hugh S Markus, Stuart M. Allan, Karen Horsburgh and Tao Wang | Summary: Cerebral small vessel disease (cSVD) is a major contributor to stroke and cognitive decline, ultimately leading to vascular dementia (VaD). Genetic factors play a key […]


Continue.. HTRA1 deficiency in COL4A1 mutant hiPSC-derived astrocytes, a convergent mechanism of cerebral small vessel disease

DeepConf: Machine Learning Conformer Reconstruction of Biomolecules from Scanning Tunneling Microscopy Images

Kavli Affiliate: Stephan Rauschenbach | Summary:Improving the detailed understanding of the underlying properties and functions of biomolecules has recently attracted growing interest, enabled by the possibility of real-space imaging of single, intact macromolecules using Scanning Tunneling Microscopy (STM) in combination with electrospray ion beam deposition and soft landing. This combination provides key insights into biomolecular […]


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Temporal Entanglement and Witnesses of Non-Classicality

Kavli Affiliate: Andrew Baldwin | Summary:The universality of quantum theory has been questioned ever since it was proposed. Key to this long-unsolved question is to test whether a given physical system has non-classical features. Here we connect recently proposed witnesses of non-classicality, based on information-theoretic ideas, with the theory of temporal entanglement. We provide a […]


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