Molecular insights into bulk lipid transport from structural studies of the bridge-like protein VPS13A complexed with the scramblase XKR1

Posted by dbos Yale

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Pietro De Camilli | Authors: Bodan Hu, Daniel Alvarez, Cristian Rocha-Roa, Valentin Guyard, Dazhi Li, Xinbo Wang, Pietro De Camilli, Stefano Vanni and Karin Reinisch | Summary: In eukaryotes, bridge-like lipid-transfer proteins (BLTPs) are central in mediating vesicle-independent lipid transfer […]


Continue.. Molecular insights into bulk lipid transport from structural studies of the bridge-like protein VPS13A complexed with the scramblase XKR1

Global context rapidly shapes sensory responses in V1

Posted by dbos Columbia

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Darcy Peterka | Authors: Darcy S Peterka, Fumiyasu Imai, Jordan M Ross, Georgia Bastos, Molly Hornick, Lital Rachmany, Connor G Gallimore, Adam Hockley and Jordan P Hamm | Summary: Context modulates sensory processing in the cerebral cortex by suppressing responses […]


Continue.. Global context rapidly shapes sensory responses in V1

A commensally regulated immune rheostat fine-tunes skin barrier fitness

Posted by dbos Rockefeller

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Elaine Fuchs | Authors: Anita Gola, Rohith Srinivas, Elias G. Rodig, Marina Schernthanner, Merve Deniz Abdusselamoglu, Matthew T. Tierney, Natalie J. Alexander, Kevin A.U. Gonzales, Sairaj M. Sajjath, Luis F. Soto-Ugaldi, Alain R. Bonny and Elaine Fuchs | Summary: At […]


Continue.. A commensally regulated immune rheostat fine-tunes skin barrier fitness

C. elegans E3 ubiquitin ligase EBAX-1 promotes non-apoptotic linker cell-type death through target-directed miRNA degradation

Posted by dbos Rockefeller

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Shai Shaham | Authors: Lauren B Horowitz, Olya Yarychkivska, Yun Lu and Shai Shaham | Summary: Programmed cell death is essential for animal development and homeostasis, and its disruption accompanies many human disorders. Linker cell-type death (LCD) is a morphologically […]


Continue.. C. elegans E3 ubiquitin ligase EBAX-1 promotes non-apoptotic linker cell-type death through target-directed miRNA degradation

Disk-to-Corona State Transition and Extreme X-ray Variability in the Tidal Disruption Event AT2019teq

Posted by klaurent MIT

Kavli Affiliate: Erin Kara | Summary:We present a five-year X-ray spectral and timing analysis of the optically selected Tidal Disruption Event (TDE) AT2019teq, which displays extreme variability, including order-of-magnitude changes in flux on minute-to-day timescales, and a rare late-time emergence of hard X-ray emission leading to the longest-lived corona in a known TDE. In one […]


Continue.. Disk-to-Corona State Transition and Extreme X-ray Variability in the Tidal Disruption Event AT2019teq

The early Universe with JWST and ALMA

Posted by klaurent Tokyo

Kavli Affiliate: John Silverman | Summary:The Atacama Large Millimeter/submillimeter Array and the James Webb Space Telescope are transforming our understanding of galaxy formation and evolution in the early Universe. By combining their capabilities, these observatories provide unprecedented insights into the gas, dust, and stars of high-redshift galaxies at spatially resolved scales, unveiling the complexities of […]


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Dopaminergic Modulation of Mushroom Body Output Neurons Mediates Nociception-Induced Escape in Drosophila

Posted by dbos UCSD / Salk

Kavli Affiliate: Ann-Shyn Chiang | Authors: Chi-Lien Yang, Chia-Wen Chen, Kuan-Lin Feng, Hsiao-Chien Peng, Ming-Chin Wu, Ching-Che Charng, Li-An Chu, Yeong-Ray Wen and Ann-Shyn Chiang | Summary: In Drosophila, noxious heat is detected by peripheral nociceptors expressing transient receptor potential (TRP) channels, including Painless and TrpA1, and rapidly triggers escape behavior. Although peripheral transduction has […]


Continue.. Dopaminergic Modulation of Mushroom Body Output Neurons Mediates Nociception-Induced Escape in Drosophila

A spectroscopically confirmed, strongly lensed, metal-poor Type II supernova at z = 5.13

Posted by klaurent Peking

Kavli Affiliate: Kohei Inayoshi | Summary:Observing supernovae (SNe) in the early Universe (z > 3) provides a window into how both galaxies and individual stars have evolved over cosmic time, yet a detailed study of high-redshift stars and SNe has remained difficult due to their extreme distances and cosmological redshifting. To overcome the former, searches […]


Continue.. A spectroscopically confirmed, strongly lensed, metal-poor Type II supernova at z = 5.13

Solvent Effects on Triplet Yields in BODIPY-Based Photosensitizers

Posted by klaurent Berkeley

Kavli Affiliate: David T. Limmer | Summary:We employ molecular dynamics simulations and quantum rate theories to elucidate the complex condensed-phase dynamics underpinning triplet-state formation in organic photosensitizers. Using models informed by first-principles calculations complete with a molecular representation of solvents of different polarities, we elucidate the interplay of the internal and environmental interactions underlying triplet […]


Continue.. Solvent Effects on Triplet Yields in BODIPY-Based Photosensitizers

Solvent Effects on Triplet Yields in BODIPY-Based Photosensitizers

Posted by klaurent Berkeley

Kavli Affiliate: David T. Limmer | Summary:We employ molecular dynamics simulations and quantum rate theories to elucidate the complex condensed-phase dynamics underpinning triplet-state formation in organic photosensitizers. Using models informed by first-principles calculations complete with a molecular representation of solvents of different polarities, we elucidate the interplay of the internal and environmental interactions underlying triplet […]


Continue.. Solvent Effects on Triplet Yields in BODIPY-Based Photosensitizers