Mutant SOD1 expressed by oligodendrocytes aggregates in myelinic nanochannels and accelerates disease progression in familial ALS mice

Posted by dbos Hopkins

Kavli Affiliate: Dwight Bergles | Authors: Alexandra I Mot, Ying Li, Payam Dibaj, Iva D Tzvetanova, Ulrike C Gerwig, Tizibt A Bogale, Sandra Goebbels, Wiebke Möbius, Dwight E Bergles, Brett M Morrison, Jeffrey D Rothstein, Don W Cleveland, Julia M Edgar and Klaus-Armin Nave | Summary: Amyotrophic lateral sclerosis (ALS) is a highly debilitating and […]


Continue.. Mutant SOD1 expressed by oligodendrocytes aggregates in myelinic nanochannels and accelerates disease progression in familial ALS mice

Ultralow frequency vaso-oscillations in human cerebral arteries are independent from Mayer waves

Posted by dbos UCSD / Salk

Kavli Affiliate: David Kleinfeld | Authors: Aiman Alzetani, Jacob Duckworth, Anthony A Birch, David M Simpson, David Kleinfeld and Roxana O Carare | Summary: This study tests the hypothesis that vasomotion, an ∼ 0.1 Hz oscillation in arteriole diameter, is generated by intrinsic oscillations within the arterioles that perfuse the brain, and not by external […]


Continue.. Ultralow frequency vaso-oscillations in human cerebral arteries are independent from Mayer waves

SPOTTER: Automated Tissue-Barcoding Platform for Spatial Proteomics and Phosphoproteomics

Posted by dbos Hopkins

Kavli Affiliate: Xingde Li | Authors: Yuanwei Xu, Hyeoncheol Park, Jason Li, Yuehan Liu, T. Mamie Lih, Chengyu Lee, Xingde Li and hui Zhan | Summary: Spatial proteomics aims to characterize proteome in situ with regional resolution, linking molecular states to tissue architecture and microenvironments. While recent advances have expanded our access to spatially resolved […]


Continue.. SPOTTER: Automated Tissue-Barcoding Platform for Spatial Proteomics and Phosphoproteomics

Complexity as a Potential Neurophysiological Correlate of Awe

Posted by dbos UCSF

Kavli Affiliate: Reza Abbasi Asl | Authors: oseph Chih Chien Chen, Gabriella Mace, Avery Ostrand, Christian Valtierra, Sydney Griffith, Richard Campusano, Andrew Li, Erin Vinson, Jonas Schlomberg, Maya Eshel, John Matthew Suntay, Syed Rahim, Roger Anguera-Singla, Bijurika Nandi, Isabella Hartley, Daniel A Brown, Nicole C Swann, Luca Mazzucato, Xin Hu, Dan Zhang, Christopher Timmermann, Maryam […]


Continue.. Complexity as a Potential Neurophysiological Correlate of Awe

Functional brain organization is stable within individuals across years

Posted by dbos UCSD / Salk

Kavli Affiliate: Deanna J. Greene | Authors: Hyejin J. Lee, Ally Dworetsky, Alexis Porter, Sihan Fei, Ashley N. Nielsen, Benjamin A. Seitzman, Babatunde Adeyemo, Patrick G. Bissett, Russell A. Poldrack, Jessica R. Cohen, Mark D’Esposito, Maital Neta, Nico U.F. Dosenbach, Steven E. Petersen, Evan M. Gordon, Deanna J. Greene and Caterina Gratton | Summary: Brain […]


Continue.. Functional brain organization is stable within individuals across years

Galaxy clusters in the VIDEO fields: detection and characterisation in the context of MOONRISE

Posted by klaurent Cambridge

Kavli Affiliate: Roberto Maiolino | Summary:We analyse the cluster content of the $sim 4.5 text deg^2$ XMM-LSS and CDFS VIDEO fields which are expected to be partially covered by the upcoming MOONRISE survey. Using AMICO and WaZP photometric redshift-based cluster finders, we construct a sample of $519$ cluster candidates detected by both finders in the […]


Continue.. Galaxy clusters in the VIDEO fields: detection and characterisation in the context of MOONRISE

Towards imaging Earth’s large-scale structures by directional geoneutrino detection with Ocean Bottom Detector

Posted by klaurent Tokyo

Kavli Affiliate: Kunio Inoue | Summary:Geoneutrinos, electron antineutrinos produced by radioactive decays of heat-producing elements (HPEs) within the Earth, provide unique insights into Earth’s interior and heat budget since their first detection in 2005 by KamLAND. Conventional geoneutrino detectors currently provide integrated global information and lack the capability to spatially resolve structures deep within the […]


Continue.. Towards imaging Earth’s large-scale structures by directional geoneutrino detection with Ocean Bottom Detector

Ultraviolet Imaging of SR 12 c with HST/WFC3: Accretion and Variability of a Giant Planet at the End Stages of Growth

Posted by klaurent Peking

Kavli Affiliate: Gregory Herczeg | Summary:Many details of the gas accretion phase during giant planet formation remain untested. We present new 0.2$unicodex2013$0.7 $μ$m UV-through-red optical imaging of the young, wide-orbit planetary-mass companion SR 12 c from the Wide Field Camera 3 (WFC3) instrument on board the Hubble Space Telescope. SR 12 c exhibits strong accretion-related […]


Continue.. Ultraviolet Imaging of SR 12 c with HST/WFC3: Accretion and Variability of a Giant Planet at the End Stages of Growth

Supermassive Black Hole Assembly from Heavy Seeds with Dynamical Friction in the BRAHMA Simulations: Implications for JWST, LISA, and the Local Universe

Posted by klaurent MIT

Kavli Affiliate: Mark Vogelsberger | Summary:The JWST discoveries of supermassive black holes (BHs) at $z gtrsim 5$ may provide key insights into their seeding origins. Using new $[18-72~rm Mpc]^3$ BRAHMA cosmological simulations, we investigate how variations in heavy-seed prescriptions, coupled with a subgrid dynamical friction model, shape BH populations at $z sim 5$ and $z […]


Continue.. Supermassive Black Hole Assembly from Heavy Seeds with Dynamical Friction in the BRAHMA Simulations: Implications for JWST, LISA, and the Local Universe