A Space-Time Hidden Markov Model for In Vivo NanoScale Synaptic Plasticity Tracking

Kavli Affiliate: Adam S. Charles, Michael Miller, and Richard Huganir | Authors: Shashwat Kumar, Gabrielle I Coste, Dasun Premathilaka, Richard L. Huganir, Austin R Graves, Adam S Charles and Michael I Miller | Summary: Synapses are the fundamental unit of neural connectivity, exhibiting dynamic functional and structural changes that enable the brain to learn, adapt, […]


Continue.. A Space-Time Hidden Markov Model for In Vivo NanoScale Synaptic Plasticity Tracking

The DESI results impact the local determination of $H_0$

Kavli Affiliate: Michael Turner | Summary:Measurements of baryon acoustic oscillations (BAO) by the Dark Energy Spectroscopic Instrument (DESI) have revealed evidence for dark energy that evolves. If local distance measurements are analyzed with the $w_0w_a$ models preferred by the DESI measurements, the value for the Hubble constant can be as much as $2.5,mathrmkm,s^-1Mpc^-1$ smaller than […]


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A Decade to Map the Diffuse Universe: FRB-QSO Pairs with HST/COS Spectroscopy

Kavli Affiliate: Kiyoshi Masui | Summary:Jointly analyzing the sightlines of arcsecond-localized fast radio bursts (FRBs) and UV-bright quasars (QSOs) nearby in projection has the potential to provide strong constraints on the phases, mass distributions, and magnetic structure of the diffuse universe. Each probe supplies what the other cannot: FRBs provide integrated electron columns (DM), line-of-sight […]


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Heavy-element paleodetectors for Higgsino dark matter

Kavli Affiliate: Peter Graham | Summary:Paleodetectors have been proposed as a new approach to direct detection of weakly interacting massive particles (WIMPs), through the search for damage tracks in ancient minerals induced by WIMP-nucleon scattering. However, for inelastic dark matter such as the Higgsino, existing paleodetector targets lack sufficiently heavy nuclei to overcome the kinematic […]


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Little red dots as a cosmological probe: constraining $H_0$ with quasi-periodic pulsations

Kavli Affiliate: Kohei Inayoshi | Summary:The James Webb Space Telescope (JWST) has uncovered a population of “little red dots” (LRDs) at $z gtrsim 4$, potentially representing early supermassive black holes embedded in dense gaseous envelopes. The recent discovery of the lensed LRD RXJ2211-RX1 reveals significant variability on rest-frame timescales of decades, which may be interpreted […]


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SMUGGLE-Ring: Evolutionary link between nuclear star cluster and nuclear disk

Kavli Affiliate: Mark Vogelsberger | Summary:We present a high-resolution hydrodynamical simulation of the formation and evolution of nuclear structures in a Milky Way-mass galaxy using the SMUGGLE multiphase ISM and stellar feedback model. The system naturally develops a bar of length $approx5$ kpc in isolation, driving sustained gas inflows toward the center that lead to […]


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Quantum Hall effect in vacancy-engineered $β$-Ag$_2$Te

Kavli Affiliate: Joseph Falson | Summary:Accessing surface quantum transport in topological insulators is hampered by residual bulk conduction arising from lattice defects. Here, we demonstrate a novel synthesis pathway for realizing high mobility $β$-Ag$_2$Te thin films where surface transport is dominant. An textitin-situ vacancy engineering step as part of the molecular beam epitaxy growth process […]


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Tunable supramolecular polymerization from protein charge heterogeneity and architecture

Kavli Affiliate: Liedewij Laan | Summary:Multidomain proteins with flexible unstructured sequence regions are abundant in cellular signaling. This protein architecture enables self-assembly into supramolecular structures, but how structured interaction domains and overall protein architecture jointly regulate the assembly size, structure and kinetics remains unclear. Here we use the budding yeast protein Bem1 as a model […]


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Granular mass perturbations on the pulsar – supermassive black hole system

Kavli Affiliate: Lijing Shao | Summary:Discovery and timing observations of a radio pulsar orbiting around Sagittarius A*, the supermassive black hole (SMBH) in our Galactic Centre (GC), will provide unprecedented opportunities of studying the SMBH spacetime, testing gravity theories, and probing the astrophysical environment in the GC. However, unknown mass distributions might cause timing residuals […]


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ABCD: The Nuclear Structure of the Little Red Dots Revealted through Absorption, Break, Continuum, and Decrement

Kavli Affiliate: Luis Ho | Summary:We present a spectroscopic analysis of 14 little red dots (LRDs) at redshifts $2.2 < z < 6.7$ using NIRSpec/MSA prism and medium-resolution grating observations, aiming to constrain the nuclear gas structure through Balmer emission-line profiles, absorption features, relative line intensities, and continuum properties. We simultaneously decompose the broad, narrow, […]


Continue.. ABCD: The Nuclear Structure of the Little Red Dots Revealted through Absorption, Break, Continuum, and Decrement