Galactic Amnesia: The Information Washout of the Milky Way Merger History

Kavli Affiliate: Lina Necib | Summary:The merger history of a galaxy leaves imprints on its present-day stellar chemodynamics, yet dynamical processes progressively erase this record. We ask: how far back in time, and from which observables, can a galaxy’s assembly history still be recovered? We provide a quantitative framework to address this question, using Mutual […]


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Perinatal Elimination of Genetically Aberrant Neurons from Human Cerebral Cortex

Kavli Affiliate: Michael Miller | Authors: Diane D Shao, Yifan Zhao, Joseph Brew, Yahia Adla, Urmi Ghosh, Vinayak V Viswanadham, Lovelace J Luquette, Sijing Zhao, Andrea J Kriz, Xuyu Qian, Takumi Taketomi, Shannon Coy, Sandro Santagata, Michael B Miller, Fuminori Tsuruta, Peter J Park and Christopher A Walsh | Summary: Human neurons are postmitotic and […]


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Multiscale Hyperbolic Embedding Reveals Hierarchical Structure in Complex Biological Systems

Kavli Affiliate: Tatyana Sharpee | Authors: Mingchen Yao, Anoop Praturu and Tatyana Sharpee | Summary: The rapid expansion of biological and computational datasets demands scalable methods that support both visualization and quantitative interpretation. Hyperbolic embeddings are well suited to represent hierarchical structure, but existing approaches are limited by fixed curvature assumptions or poor scalability to […]


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Fixed human pangenome sequences reveal origins of common human traits

Kavli Affiliate: Erich Jarvis | Authors: Chern-sing Goh, Matthew Davenport, Chul Lee and Erich Jarvis | Summary: Humans possess human-specific traits1,2 such as spoken language and lineage-specific traits such as ape-specific taillessness3,4. Previous efforts to identify the DNA sequences responsible for such human traits were limited by necessary accommodations for poor genome assembly quality and […]


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On Computing Total Variation Distance Between Mixtures of Product Distributions

Kavli Affiliate: Anqi Zhang| Summary:We study the problem of approximating the total variation distance between two mixtures of product distributions over an $n$-dimensional discrete domain. Given two mixtures $mathbbP$ and $mathbbQ$ with $k_1$ and $k_2$ product distributions over $[q]^n$, respectively, we give a randomized algorithm that approximates $d_mathrmTVleft(mathbbP,mathbbQright)$ within a multiplicative error of $(1pm varepsilon)$ […]


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New constraints on primordial non-Gaussianity from large-scale cross-correlations of CMB lensing and the cosmic infrared background

Kavli Affiliate: Blake Sherwin | Summary:We present new constraints on the local-type primordial non-Gaussianity parameter, $f_mathrmNL^mathrmlocal$, through analysis of the scale-dependent bias effect on the cosmic infrared background (CIB). To avoid biases from galactic dust contamination on large scales, we use cross-correlations between the CIB and Planck cosmic microwave background (CMB) lensing maps to constrain […]


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High-Dimensional Tests for Elliptical Models via Radial–Directional Dependence

Kavli Affiliate: Feng Long| Summary: We develop high-dimensional goodness-of-fit tests for elliptical models by testing radial–directional independence after affine standardization. The method forms coordinatewise correlations between the log-radius and directional components, using a sum statistic for dense departures, a max statistic for sparse departures, and a Cauchy combination for adaptation. We derive oracle null limits, […]


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High-Dimensional Two-Sample Test for Elliptical Symmetry Distribution

Kavli Affiliate: Feng Long| Summary: We study the high-dimensional two-sample location problem under elliptical symmetry with arbitrary dependence in the scatter matrix. Existing spatial-sign procedures are attractive for heavy-tailed data, but their null calibration is tied to weakly dependent scatter matrices and their diagonal standardization does not, in general, recover the diagonal shape under strong […]


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