Kavli Affiliate: Seth Shipman | Authors: Jihoon Han and Seth Shipman | Summary: Here, we introduce Detectrons, modular biosensors that couples programmable toehold switches with retron-mediated reverse transcription to transduce RNA inputs into unique DNA barcodes. The ability to convert dynamic RNA signals into durable DNA records within living cells unlocks powerful new modes of […]
Continue.. Programmable RNA detection generates DNA barcodes for multiplexed phage-host interaction screening