Large-scale simulations reveal evolutionary constraints on intrinsically disordered regions imposed by full-length protein architecture

Kavli Affiliate: Li Zhao | Authors: Yang Jiang, Xiaoyang Liu, Li Zhao and Zhong-Yuan Lu | Summary: Intrinsically disordered regions (IDRs) are pervasive in eukaryotic proteomes and play central roles in regulatory complexity and evolutionary innovation. While their conformational ensembles have been extensively characterized in isolation, most long IDRs function within multidomain proteins, where domain […]


Continue.. Large-scale simulations reveal evolutionary constraints on intrinsically disordered regions imposed by full-length protein architecture

Recurrent Connectivity Shapes Spatial Coding in Hippocampal CA3 Subregions

Kavli Affiliate: Darcy Peterka and Attila Losonczy | Authors: Eunji Kong, Erfan Zabeh, Zhenrui Liao, Tiberiu S. Mihaila, Darcy S. Peterka, Caroline Wilson, Charan Santhirasegaran, Tristan Geiller and Attila Losonczy | Summary: Stable and flexible neural representations of space in the hippocampus are crucial for navigating complex environments. However, how these distinct representations emerge from […]


Continue.. Recurrent Connectivity Shapes Spatial Coding in Hippocampal CA3 Subregions

Small hosts, big appetites: unveiling rapid and early low-mass black hole growth in cosmological zoom-in simulations of dwarf galaxies

Kavli Affiliate: Roberto Maiolino | Summary:Dwarf galaxies are ideal laboratories to probe the interplay between galaxy formation and the growth of black holes (BHs) in the early Universe. Mounting observational evidence reveals the presence of BHs in low-mass galaxies across cosmic time, with $textitJWST$ uncovering a likely population of $textitovermassive$ BHs at $2 lesssim z […]


Continue.. Small hosts, big appetites: unveiling rapid and early low-mass black hole growth in cosmological zoom-in simulations of dwarf galaxies

GA-NIFS: Dissecting The Alchemised: NIRSpec/IFU reveals turbulent gas inflows in a complex system at $z=10.17$

Kavli Affiliate: Roberto Maiolino | Summary:Recent observations revealed that distant galaxies have bursty star formation histories, regulated by stellar or active galactic nuclei (AGN) feedback and gas inflows. According to theoretical models, feedback preferentially removes metal-rich gas, while subsequent starbursts are triggered by mergers and newly-accreted gas that is generally less enriched than the galaxy […]


Continue.. GA-NIFS: Dissecting The Alchemised: NIRSpec/IFU reveals turbulent gas inflows in a complex system at $z=10.17$

GA-NIFS: Dissecting The Alchemised: NIRSpec/IFU reveals turbulent gas inflows in a complex system at $z=10.17$

Kavli Affiliate: Roberto Maiolino | Summary:Recent observations revealed that distant galaxies have bursty star formation histories, regulated by stellar or active galactic nuclei (AGN) feedback and gas inflows. According to theoretical models, feedback preferentially removes metal-rich gas, while subsequent starbursts are triggered by mergers and newly-accreted gas that is generally less enriched than the galaxy […]


Continue.. GA-NIFS: Dissecting The Alchemised: NIRSpec/IFU reveals turbulent gas inflows in a complex system at $z=10.17$

Discovery of a nearby radio relic in the low-mass, merging cluster Abell 4067

Kavli Affiliate: Lindsey Bleem | Summary:Shock waves generated during cluster mergers offer a powerful probe of how large-scale structure grows and evolves in the Universe. As part of the MeerKAT-South Pole Telescope (SPT) survey, we report the discovery of a single arc-like radio relic in the galaxy cluster Abell 4067 ($z=0.099$), one of the lowest-mass […]


Continue.. Discovery of a nearby radio relic in the low-mass, merging cluster Abell 4067

MesoMem: A mesoscale membrane model based on an additive potential

Kavli Affiliate: Timon Idema | Summary:Bridging the gap between atomistic detail and continuum mechanics is a central challenge in modeling biological membranes, particularly for mesoscopic phenomena spanning large length and time scales. In this work, we introduce a new, solvent-free, one-particle-thick, coarse-grained model for lipid bilayers, governed by an additive potential. Our approach treats orientational […]


Continue.. MesoMem: A mesoscale membrane model based on an additive potential

Constraining the mass of the M31 ionized baryon Halo using CHIME/FRB Catalog 2

Kavli Affiliate: Kiyoshi Masui | Summary:The circumgalactic medium (CGM) surrounding galaxies is believed to be a significant reservoir of baryons, yet its total mass remains poorly constrained. We present a novel approach to probe the CGM of the Andromeda galaxy (M31) using fast radio bursts (FRBs) from the CHIME/FRB Catalog 2. By comparing the dispersion […]


Continue.. Constraining the mass of the M31 ionized baryon Halo using CHIME/FRB Catalog 2

Constraining the mass of the M31 ionized baryon Halo using CHIME/FRB Catalog 2

Kavli Affiliate: Kiyoshi Masui | Summary:The circumgalactic medium (CGM) surrounding galaxies is believed to be a significant reservoir of baryons, yet its total mass remains poorly constrained. We present a novel approach to probe the CGM of the Andromeda galaxy (M31) using fast radio bursts (FRBs) from the CHIME/FRB Catalog 2. By comparing the dispersion […]


Continue.. Constraining the mass of the M31 ionized baryon Halo using CHIME/FRB Catalog 2

Extending Ground-Based Gravitational-Wave Sensitivity to 5 Hz

Kavli Affiliate: Peter Fritschel | Summary:Extending the sensitivity of terrestrial gravitational-wave detectors below 20 Hz is a long-standing challenge, limited by ground motion and inertial sensing noise. In this letter, we demonstrate ultra-high-vacuum compatible inertial isolation and position sensing technologies that achieve active platform stabilization down to 10 mHz. Our laser position sensors reach a […]


Continue.. Extending Ground-Based Gravitational-Wave Sensitivity to 5 Hz