mPFC Synaptosome Proteomics Reveals Novel Pathways and Muscarinic Receptor Changes in a Learned Helplessness Mouse Model

Kavli Affiliate: Marina Picciotto | Authors: Zuhair I Abdulla, Rolando Garcia-Milian, Ernestine Giahyue, Sofia Fertuzinhos, Florine Collin, Weiwei Wang, TuKiet Lam, Angus Nairn and Marina R Picciotto | Summary: Stressful events are a leading factor in development of depression. The medial prefrontal cortex (mPFC) is strongly associated with depression etiology and exposure to uncontrollable stressors […]


Continue.. mPFC Synaptosome Proteomics Reveals Novel Pathways and Muscarinic Receptor Changes in a Learned Helplessness Mouse Model

Radial and Rotational Velocities of a Volume-Complete Sample of M Dwarfs with Masses 0.1-0.3 Msun within 15 parsecs

Kavli Affiliate: David Charbonneau | Summary:We present the results from a five-year campaign to gather multi-epoch, high-resolution spectra of a volume-complete sample of 413 M dwarfs with masses 10-30% that of the Sun that lie within 15 parsecs. We report weighted mean systemic radial velocities (RV) and rotational broadening measurements ($v sin i$) for our […]


Continue.. Radial and Rotational Velocities of a Volume-Complete Sample of M Dwarfs with Masses 0.1-0.3 Msun within 15 parsecs

Dynamic Regulation of CD300b, and CD300f on Myeloid Cells in Oral Immunotherapy

Kavli Affiliate: Jean Fan | Authors: Caleb Hallinan, Hyun Joo Ji, Edmund Tsou, Steven L Salzberg and Jean Fan | Summary: The accuracy of spatial gene expression profiles generated by probe-based in situ spatially-resolved transcriptomic technologies depends on the specificity with which probes bind to their intended target gene. Off-target binding, defined as a probe […]


Continue.. Dynamic Regulation of CD300b, and CD300f on Myeloid Cells in Oral Immunotherapy

MATRIX: A Multimodal Benchmark and Post-Training Framework for Materials Science

Kavli Affiliate: Gerbrand Ceder| Summary:Scientific reasoning in materials science requires integrating multimodal experimental evidence with underlying physical theory. Existing benchmarks make it difficult to assess whether incorporating visual experimental data during post-training improves mechanism-grounded explanation reasoning beyond text-only supervision. We introduce MATRIX, a multimodal benchmark for materials science reasoning that evaluates foundational theory, research-level reasoning, […]


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Evidence of off-target probe binding affecting 10x Genomics Xenium gene panels compromise accuracy of spatial transcriptomic profiling

Kavli Affiliate: Jean Fan | Authors: Caleb Hallinan, Hyun Joo Ji, Edmund Tsou, Steven L Salzberg and Jean Fan | Summary: The accuracy of spatial gene expression profiles generated by probe-based in situ spatially-resolved transcriptomic technologies depends on the specificity with which probes bind to their intended target gene. Off-target binding, defined as a probe […]


Continue.. Evidence of off-target probe binding affecting 10x Genomics Xenium gene panels compromise accuracy of spatial transcriptomic profiling

Shared Maturation Pathways of HIV-1 Envelope-reactive V3-glycan bnAb Lineages in Human and Rhesus Macaque

Kavli Affiliate: Robert Edwards | Authors: Matthew Clark, Hui Li, Mitchell Martin, Tyler Evangelous, Sophie Gobeil, Madison Berry, Kshitij Wagh, Elena Giorgi, Michael Hogarty, Chengyan Zhao, Shuyi Wang, Lorie Marchitto, Wenge Ding, Younghoon Park, Juliette Rando, John Carey, Andrew Connell, Ashwin Skelly, Yue Chen, Seth Rohr, Chuancang Jiang, Sravani Venkatayogi, Katayoun Mansouri, Robert J. Edwards, […]


Continue.. Shared Maturation Pathways of HIV-1 Envelope-reactive V3-glycan bnAb Lineages in Human and Rhesus Macaque

3D Printed Alumina as a Millimeter-Wave Optical Element

Kavli Affiliate: Tomotake Matsumura | Summary:We present millimeter and sub-millimeter room temperature transmission and loss measurements of 3D printed alumina disc and of a disc with one-sided 3D printed sub-wavelength structures anti-reflection coatings (SWS-ARC). For four bands spanning 158 – 700~GHz we find an index of refraction consistent with $n= 3.107 pm 0.007$. The loss […]


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Supernova Rates and Luminosity Functions from ASAS-SN III: Over a Decade of Type Ia SNe and Their Subtypes

Kavli Affiliate: Subo Dong | Summary:We present volumetric rates and luminosity functions (LFs) of Type Ia supernovae (SNe Ia) from the All-Sky Automated Survey for Supernovae (ASAS-SN), covering the 11-year period from 2014 to 2024. By combining the 2014–2017 $V$-band sample with the 2018–2024 $g$-band sample, we construct a large statistical dataset of $1776$ SNe […]


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Weight-four parity checks with silicon spin qubits

Kavli Affiliate: Lieven Vandersypen | Summary:Recent advances in coherent spin shuttling have made sparse semiconductor spin qubit arrays an appealing solid-state platform to realize quantum processors. The dynamic and long-range connectivity enabled by shuttling is also essential for many quantum error-correction (QEC) schemes. Here, we demonstrate a silicon spin-qubit device that comprises a shuttling bus […]


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The Effect of Tidal Heating and Volatile Budgets on the Outgassed Atmosphere of 55 Cancri e

Kavli Affiliate: Laura Schaefer | Summary:55 Cancri e is a $sim$8 Gyr rocky world (1.95 $R_oplus$, 8.8 $M_oplus$) orbiting a K-type star. JWST observations suggest a carbon-dominated atmosphere (CO$_2$/CO) over a global magma ocean ($>$3000 K). We suggest that any CO$_2$-dominated atmosphere, with trace H$_2$O/O$_2$, likely arises from outgassing of its initial volatile reservoir. As […]


Continue.. The Effect of Tidal Heating and Volatile Budgets on the Outgassed Atmosphere of 55 Cancri e