Astrocyte redox imbalance underlies prelimbic neuronal hypoactivity and affective behavior in epilepsy

Kavli Affiliate: Dwight Bergles | Authors: Travis E Faust, Atsushi Saito, Shoichi Ishikawa, Kun Yang, Wendy Xin, Ho Namkung, Amit Agarwal, Adriana Ramos, Brian J Lee, Lindsay Hayes, Rupali Srivastava, Sunday Adelakun, Sneha Saha, Trexy Palen, Tyler Cash-Padgett, Daniel Wood, Elisa Carloni, Ryosuke Yusa, Hanna Jaaro-Peled, Jed W Fahey, Dwight E Bergles, Koko Ishizuka and […]


Continue.. Astrocyte redox imbalance underlies prelimbic neuronal hypoactivity and affective behavior in epilepsy

Immune cells adapt to distinct stem cell niches to govern tissue homeostasis

Kavli Affiliate: Daniel Mucida and Elaine Fuchs | Authors: Sara Martina Parigi, Sairaj Munavar Sajjath, Charlotte Jeanne Bell, Shaopeng Yuan, Vitoria Murakami Olyntho, Alain Robert Bonny, Sandra Nakandakari-Higa, Sergio Lira, Daniel Mucida, Gabriel D Victora and Elaine Fuchs | Summary: In adult tissues, epithelial stem cells exist within distinct residences, each endowing them with exclusive […]


Continue.. Immune cells adapt to distinct stem cell niches to govern tissue homeostasis

Down-bending Breaks in Galactic Disks Are an Intrinsic Byproduct of Inside-out Growth

Kavli Affiliate: Luis Ho | Summary:The exponential profile has long been hypothesized as the fundamental morphology of galactic disks. The IllustrisTNG simulations reproduce diverse surface-density profiles: Type I (single exponential), Type II (down-bending), and Type III (up-bending), consistent with observed mass-size relations and kinematics. Type II disks dominate the stellar-mass regime $M_star < 10^10.6 M_odot$ […]


Continue.. Down-bending Breaks in Galactic Disks Are an Intrinsic Byproduct of Inside-out Growth

Down-bending Breaks in Galactic Disks Are an Intrinsic Byproduct of Inside-out Growth

Kavli Affiliate: Luis Ho | Summary:The exponential profile has long been hypothesized as the fundamental morphology of galactic disks. The IllustrisTNG simulations reproduce diverse surface-density profiles: Type I (single exponential), Type II (down-bending), and Type III (up-bending), consistent with observed mass-size relations and kinematics. Type II disks dominate the stellar-mass regime $M_star < 10^10.6 M_odot$ […]


Continue.. Down-bending Breaks in Galactic Disks Are an Intrinsic Byproduct of Inside-out Growth

mPFC Synaptosome Proteomics Reveals Novel Pathways and Muscarinic Receptor Changes in a Learned Helplessness Mouse Model

Kavli Affiliate: Marina Picciotto | Authors: Zuhair I Abdulla, Rolando Garcia-Milian, Ernestine Giahyue, Sofia Fertuzinhos, Florine Collin, Weiwei Wang, TuKiet Lam, Angus Nairn and Marina R Picciotto | Summary: Stressful events are a leading factor in development of depression. The medial prefrontal cortex (mPFC) is strongly associated with depression etiology and exposure to uncontrollable stressors […]


Continue.. mPFC Synaptosome Proteomics Reveals Novel Pathways and Muscarinic Receptor Changes in a Learned Helplessness Mouse Model

Radial and Rotational Velocities of a Volume-Complete Sample of M Dwarfs with Masses 0.1-0.3 Msun within 15 parsecs

Kavli Affiliate: David Charbonneau | Summary:We present the results from a five-year campaign to gather multi-epoch, high-resolution spectra of a volume-complete sample of 413 M dwarfs with masses 10-30% that of the Sun that lie within 15 parsecs. We report weighted mean systemic radial velocities (RV) and rotational broadening measurements ($v sin i$) for our […]


Continue.. Radial and Rotational Velocities of a Volume-Complete Sample of M Dwarfs with Masses 0.1-0.3 Msun within 15 parsecs

Dynamic Regulation of CD300b, and CD300f on Myeloid Cells in Oral Immunotherapy

Kavli Affiliate: Jean Fan | Authors: Caleb Hallinan, Hyun Joo Ji, Edmund Tsou, Steven L Salzberg and Jean Fan | Summary: The accuracy of spatial gene expression profiles generated by probe-based in situ spatially-resolved transcriptomic technologies depends on the specificity with which probes bind to their intended target gene. Off-target binding, defined as a probe […]


Continue.. Dynamic Regulation of CD300b, and CD300f on Myeloid Cells in Oral Immunotherapy

MATRIX: A Multimodal Benchmark and Post-Training Framework for Materials Science

Kavli Affiliate: Gerbrand Ceder| Summary:Scientific reasoning in materials science requires integrating multimodal experimental evidence with underlying physical theory. Existing benchmarks make it difficult to assess whether incorporating visual experimental data during post-training improves mechanism-grounded explanation reasoning beyond text-only supervision. We introduce MATRIX, a multimodal benchmark for materials science reasoning that evaluates foundational theory, research-level reasoning, […]


Continue.. MATRIX: A Multimodal Benchmark and Post-Training Framework for Materials Science

Evidence of off-target probe binding affecting 10x Genomics Xenium gene panels compromise accuracy of spatial transcriptomic profiling

Kavli Affiliate: Jean Fan | Authors: Caleb Hallinan, Hyun Joo Ji, Edmund Tsou, Steven L Salzberg and Jean Fan | Summary: The accuracy of spatial gene expression profiles generated by probe-based in situ spatially-resolved transcriptomic technologies depends on the specificity with which probes bind to their intended target gene. Off-target binding, defined as a probe […]


Continue.. Evidence of off-target probe binding affecting 10x Genomics Xenium gene panels compromise accuracy of spatial transcriptomic profiling

Shared Maturation Pathways of HIV-1 Envelope-reactive V3-glycan bnAb Lineages in Human and Rhesus Macaque

Kavli Affiliate: Robert Edwards | Authors: Matthew Clark, Hui Li, Mitchell Martin, Tyler Evangelous, Sophie Gobeil, Madison Berry, Kshitij Wagh, Elena Giorgi, Michael Hogarty, Chengyan Zhao, Shuyi Wang, Lorie Marchitto, Wenge Ding, Younghoon Park, Juliette Rando, John Carey, Andrew Connell, Ashwin Skelly, Yue Chen, Seth Rohr, Chuancang Jiang, Sravani Venkatayogi, Katayoun Mansouri, Robert J. Edwards, […]


Continue.. Shared Maturation Pathways of HIV-1 Envelope-reactive V3-glycan bnAb Lineages in Human and Rhesus Macaque