Kavli Affiliate: Michael Goldberg | Authors: Peter McHale, Michael E Goldberg and Aaron R Quinlan | Summary: A longstanding goal in human genetics is to prioritize noncoding loci that, when disrupted, lead to developmental disorders and other Mendelian traits. In pursuit of this goal, multiple metrics have been developed to distinguish neutrally evolving sequences from […]
Continue.. The performance of genetic-constraint metrics varies significantly across the human noncoding genome