VIP-OT: Dissecting Single-Cell Biochemical State Dynamics under Perturbation via Vibrational Painting and Optimal Transport

Kavli Affiliate: Wei Min | Authors: Xuemeng Li, Stefan G. Stark, Xinwen Liu, Mian Wei, Zhilun Zhao, Jianhuan Qi, Xingjian Chen, Thai Nam Son Dang, Yinghan Wu, Ke Zhang, Wei Min and Jian Shu | Summary: Dissecting the heterogeneous response of individual cells towards genetic and chemical perturbations is central to understanding the dynamic functions […]


Continue.. VIP-OT: Dissecting Single-Cell Biochemical State Dynamics under Perturbation via Vibrational Painting and Optimal Transport

Transcriptional response to chronic long-access fentanyl self-administration in rat habenula and amygdala

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Patricia Janak | Authors: Robin Magnard, Daianna Gonzalez-Padilla, Ege A. Yalcinbas, Emma Chaloux-Pinette, Nicholas J. Eagles, Michael S. Totty, Patricia H. Janak, Leonardo Collado-Torres and Kristen R. Maynard | Summary: Fentanyl is a potent synthetic opioid associated with overdose. However, […]


Continue.. Transcriptional response to chronic long-access fentanyl self-administration in rat habenula and amygdala

Melting LHC detectors: a novel search for stopped long-lived particles

Kavli Affiliate: Peter Graham | Summary:Particles at the TeV scale with lifetimes of a year or longer could have been abundantly produced at the LHC yet escaped detection because of backgrounds, and could still be trapped within detector materials. With gluinos in split-supersymmetry as a working example, we show that these trapped particles can be […]


Continue.. Melting LHC detectors: a novel search for stopped long-lived particles

Top-down control of sustained attention by the medial prefrontal cortex (mPFC)- locus coeruleus (LC) circuit during the rodent continuous performance task (rCPT)

Kavli Affiliate: Keri Martinowich | Authors: Jason J Rehg, Daniel E Olivares, Ye Li, Keri Martinowich, Greg V Carr and Jorge Miranda-Barrientos | Summary: control to allocate cognitive resources toward behaviorally relevant stimuli based on learned context and expectations. mPFC neurons project to multiple cortical and subcortical regions, including the locus coeruleus (LC)—the brain’s primary […]


Continue.. Top-down control of sustained attention by the medial prefrontal cortex (mPFC)- locus coeruleus (LC) circuit during the rodent continuous performance task (rCPT)

From Earths to Super-Earths: Five New Small Planets Transiting M Dwarf Stars

Kavli Affiliate: Avi Shporer | Summary:Earth-sized planets transiting M dwarf stars present one of the best opportunities with current facilities for studying the atmospheric and bulk compositions of terrestrial worlds. Here, we statistically validate five new transiting Earth and super-Earth sized planets orbiting M dwarf stars using a combination of light curves from the Transiting […]


Continue.. From Earths to Super-Earths: Five New Small Planets Transiting M Dwarf Stars

Detection of Partial Coherence due to Multipath Propagation for FRB 20220413B with CHIME/FRB

Kavli Affiliate: Kiyoshi Masui | Summary:Fast radio bursts (FRBs) are a $sim$ millisecond-long transient phenomenon that propagate across extragalactic distances and are effectively a point source. Radio wave propagation through inhomogeneous distributions of plasma can act as a lens, generating multiple images of the emitted electric field. A lens can produce images of a point […]


Continue.. Detection of Partial Coherence due to Multipath Propagation for FRB 20220413B with CHIME/FRB

Nuclear magnetic resonance on a single atom with a local probe

Kavli Affiliate: Sander Otte | Summary:The nuclear spin is a prime candidate for quantum information applications due to its weak coupling to the environment and inherently long coherence times. However, this weak coupling also challenges the addressability of the nuclear spin. Here we demonstrate nuclear magnetic resonance (NMR) on a single on-surface atom using a […]


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Dynamical evolution of massless particles in star clusters with NBODY6++GPU-MASSLESS: II. The long-term evolution of free-floating comets

Kavli Affiliate: Rainer Spurzem | Summary:Context. Comets, asteroids, planetesimals, free-floating planets and brown dwarfs, are continuously injected into the intra-cluster environment after expulsion from their host planetary systems or binary system. The dynamics of large populations of such free-floating comets (ffcs) in a star cluster environment is not yet fully understood. Aims. We investigate the […]


Continue.. Dynamical evolution of massless particles in star clusters with NBODY6++GPU-MASSLESS: II. The long-term evolution of free-floating comets

Words to Describe What I’m Feeling: Exploring the Potential of AI Agents for High Subjectivity Decisions in Advance Care Planning

Kavli Affiliate: Hsiao-Mei (Sherry) Cho| First 5 Authors: [#item_custom_name[1, [#item_custom_name[2, [#item_custom_name[3, [#item_custom_name[4, [#item_custom_name[5| Summary:Loss of decisional capacity, coupled with the increasing absence of reliable human proxies, raises urgent questions about how individuals’ values can be represented in Advance Care Planning (ACP). To probe this fraught design space of high-risk, high-subjectivity decision support, we built an […]


Continue.. Words to Describe What I’m Feeling: Exploring the Potential of AI Agents for High Subjectivity Decisions in Advance Care Planning

Lysosomal swelling triggers LRRK2 activity

Kavli Affiliate: Shawn Fergusons | Authors: Tuyana Malankhanova, Zhiyong Liu, Samuel Strader, Weiping Wang, Ki Woon Sung, Zhong Li, Shawn M Ferguson and Andrew B West | Summary: LRRK2 is implicated in lysosomal functions, but the physiological upstream cues that engage endogenous LRRK2 activity are incompletely defined. Here we show that lysosomal swelling serves as […]


Continue.. Lysosomal swelling triggers LRRK2 activity