Perturb-seq reveals distinct responses to pluripotency regulator dosages underlying the control of self-renewal and differentiation

Posted by dbos Hopkins

Kavli Affiliate: Michael Beer | Authors: Jielin Yan, Hyein S. Cho, Renhe Luo, Michael A. Beer, Wei Li and Danwei Huangfu | Summary: Precise regulation of transcription factor (TF) expression is critical for maintaining cell identity, but studies on how graded expression levels affect cellular phenotypes are limited. To address this gap, we employed human […]


Continue.. Perturb-seq reveals distinct responses to pluripotency regulator dosages underlying the control of self-renewal and differentiation

CK2 inhibition suppresses glial inflammation in the brain

Posted by dbos UCSD / Salk

Kavli Affiliate: Nicola Allen | Authors: Fred H Gage, Ioana I N Da Silva, Desiree Ramirez, Sarah L Parylak, Leslie A Wallace, James K Tucker, Joel M Erberich, Rutvi Katariya, Aidan H McDonald, Iryna S Gallina, Ariana L Tucker, Jillybeth Burgado, Baptiste N Jaeger, Jerika J Barron, Joshua M Pratt, Monique Pena, Vipula Racha, Christina […]


Continue.. CK2 inhibition suppresses glial inflammation in the brain

Prefrontal gamma oscillations engage dynamic cell type-specific configurations to support flexible behavior

Posted by dbos UCSF

Kavli Affiliate: Vikaas Sohal | Authors: Aarron Justin Phensy, Lara Louise Hagopian, Caitriona M. Costello, Simon Haziza, Omkar Ghenand, Yanping Zhang, Mark J. Schnitzer and Vikaas Singh Sohal | Summary: Cognitive dysfunction in conditions such as schizophrenia involves disrupted communication between the prefrontal cortex (PFC) and mediodorsal thalamus (MD). Parvalbumin interneurons (PVI) are known to […]


Continue.. Prefrontal gamma oscillations engage dynamic cell type-specific configurations to support flexible behavior

A flexible test facility for liquid xenon detector development

Posted by klaurent Stanford

Kavli Affiliate: Giorgio Gratta | First 5 Authors: Evan Angelico, Evan Angelico, , , | Summary: As liquid xenon time projection chambers scale to ever-larger sizes, so too do the engineering challenges they pose. We describe a large, flexible, multipurpose test facility capable of supporting the development of a number of key aspects of liquid […]


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X-ray and radio polarimetry of the neutron star low mass X-ray binary GX 13+1

Posted by klaurent MIT

Kavli Affiliate: Herman L. Marshall | First 5 Authors: Unnati Kashyap, Unnati Kashyap, , , | Summary: We report the X-ray and radio polarization study of the neutron star (NS) low-mass X-ray binary (LMXB) GX 13+1 using the Imaging X-ray Polarimetry Explorer (IXPE) and Very Large Array (VLA). Simultaneous Neutron Star Interior Composition Explorer (NICER) […]


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Universal Magnetocaloric Effect near Quantum Critical Point of Magnon Bose-Einstein Condensation

Posted by klaurent UCAS

Kavli Affiliate: Gang Su | First 5 Authors: Junsen Xiang, Junsen Xiang, , , | Summary: Bose-Einstein condensation (BEC), a macroscopic quantum phenomenon arising from phase coherence and bosonic statistics, has been realized in quantum magnets. Here, we report the observation of a universal magnetocaloric effect (MCE) near a BEC quantum critical point (QCP) in […]


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AutoIAD: Manager-Driven Multi-Agent Collaboration for Automated Industrial Anomaly Detection

Posted by klaurent UCAS

Kavli Affiliate: Yi Zhou | First 5 Authors: Dongwei Ji, Dongwei Ji, , , | Summary: Industrial anomaly detection (IAD) is critical for manufacturing quality control, but conventionally requires significant manual effort for various application scenarios. This paper introduces AutoIAD, a multi-agent collaboration framework, specifically designed for end-to-end automated development of industrial visual anomaly detection. […]


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Cogito, ergo – strings: Supersymmetric ergoregions and their stringy excitations

Posted by klaurent Chicago

Kavli Affiliate: Emil J. Martinec | First 5 Authors: Emil J. Martinec, Emil J. Martinec, , , | Summary: Supergravity solutions describing supersymmetric rotating bound states of NS fivebranes, fundamental strings and momentum can sometimes have an ergoregion but no horizon. In such supersymmetric ergoregions, there is an unusual feature that there exist BPS "excitations" […]


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Computational Design and Fabrication of Modular Robots with Untethered Control

Posted by klaurent Caltech

Kavli Affiliate: Chiara Daraio | First 5 Authors: Manas Bhargava, Manas Bhargava, , , | Summary: Natural organisms utilize distributed actuation through their musculoskeletal systems to adapt their gait for traversing diverse terrains or to morph their bodies for varied tasks. A longstanding challenge in robotics is to emulate this capability of natural organisms, which […]


Continue.. Computational Design and Fabrication of Modular Robots with Untethered Control

Computational Design and Fabrication of Modular Robots with Untethered Control

Posted by klaurent Caltech

Kavli Affiliate: Chiara Daraio | First 5 Authors: Manas Bhargava, Manas Bhargava, , , | Summary: Natural organisms use distributed actuation via their musculoskeletal systems to adapt their gait for traversing diverse terrains or to morph their bodies to perform varied tasks. A longstanding challenge in the field of robotics is to mimic this extensive […]


Continue.. Computational Design and Fabrication of Modular Robots with Untethered Control